Cannabis Compound Database: Showing Protein S-methylmethionine--homocysteine S-methyltransferase BHMT2 (CDBP02405)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP02405

Secondary Accession Numbers

Not Available

Name

S-methylmethionine--homocysteine S-methyltransferase BHMT2

Description

Not Available

Synonyms

SMM-hcy methyltransferase
Betaine--homocysteine S-methyltransferase 2

Gene Name

BHMT2

Protein Type

Enzyme

Biological Properties

General Function

Involved in zinc ion binding

Specific Function

Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor.

GO Classification

Biological Process
amino-acid betaine catabolic process
methionine biosynthetic process
Cellular Component
cytoplasm
Component
cell part
intracellular part
cytoplasm
Function
transferase activity
homocysteine s-methyltransferase activity
s-methyltransferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
betaine-homocysteine s-methyltransferase activity
transition metal ion binding
zinc ion binding
Molecular Function
metal ion binding
betaine-homocysteine S-methyltransferase activity
homocysteine S-methyltransferase activity
zinc ion binding
Process
metabolic process
cellular metabolic process
sulfur amino acid metabolic process
sulfur amino acid biosynthetic process
methionine biosynthetic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
L-methionine biosynthesis via de novo pathway	Not Available	Not Available
betaine degradation	Not Available	Not Available

Gene Properties

Chromosome Location

Locus

5q13

SNPs

BHMT2

Gene Sequence

>1092 bp
ATGGCACCTGCTGGACGCCCGGGGGCCAAGAAGGGGATTTTGGAGCGCCTGGAGAGTGGG
GAGGTTGTGATTGGAGATGGCAGCTTTCTCATTACTCTGGAGAAGAGAGGCTATGTGAAG
GCTGGGCTCTGGACTCCAGAGGCAGTGATAGAACACCCAGACGCAGTTCGTCAACTTCAC
ATGGAATTCTTGAGAGCAGGATCAAATGTCATGCAGACTTTTACCTTTTCTGCCAGTGAG
GACAATATGGAAAGCAAGTGGGAAGATGTAAATGCTGCTGCCTGTGACCTCGCCAGGGAA
GTGGCTGGCAAAGGTGATGCTTTGGTAGCAGGGGGGATCTGCCAGACATCAATATACAAA
TACCAGAAGGATGAAGCTAGAATTAAAAAACTTTTTCGACAACAGCTAGAAGTTTTTGCC
TGGAAAAATGTGGACTTCTTGATTGCAGAGTATTTTGAGCACGTTGAAGAAGCTGTGTGG
GCTGTGGAAGTCTTAAAAGAATCAGATAGACCCGTGGCAGTTACCATGTGCATAGGCCCA
GAGGGAGACATGCATGATATAACCCCCGGAGAATGTGCTGTGAGGCTGGTGAAGGCAGGG
GCTTCCATCGTTGGCGTGAACTGCCGCTTTGGGCCCGACACCAGCTTGAAGACGATGGAG
CTCATGAAGGAGGGTCTTGAGTGGGCAGGGCTGAAAGCGCACCTCATGGTGCAGCCTCTG
GGGTTCCACGCGCCTGACTGTGGCAAAGAGGGGTTTGTGGATCTCCCAGAATATCCCTTT
GGACTGGAGTCCAGAGTTGCCACCAGATGGGATATTCAAAAATACGCCAGAGAGGCCTAC
AACCTGGGGGTCAGGTACATTGGCGGGTGCTGTGGATTTGAGCCCTACCACATCAGGGCA
ATTGCAGAGGAGCTGGCCCCAGAAAGGGGCTTTTTGCCACCAGCTTCAGAAAAACACGGC
AGCTGGGGAAGTGGTTTGGACATGCACACCAAACCCTGGATTAGAGCAAGGGCTCGAAGG
GAGTATTGGGAGAATCTGCTGCCAGCTTCAGGCAGACCTTTCTGTCCTTCGCTGTCAAAG
CCAGACTTCTAA

Protein Properties

Number of Residues

363

Molecular Weight

33166.69

Theoretical pI

5.973

Pfam Domain Function

S-methyl_trans (PF02574 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Betaine--homocysteine S-methyltransferase 2
MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVIEHPDAVRQLH
MEFLRAGSNVMQTFTFSASEDNMESKWEDVNAAACDLAREVAGKGDALVAGGICQTSIYK
YQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGP
EGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPL
GFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRA
IAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSK
PDF

External Links

GenBank ID Protein

11907831

UniProtKB/Swiss-Prot ID

Q9H2M3

UniProtKB/Swiss-Prot Entry Name

BHMT2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF257473

GeneCard ID