| Identification |
|---|
| HMDB Protein ID
| CDBP02392 |
| Secondary Accession Numbers
| Not Available |
| Name
| V-type proton ATPase subunit D |
| Description
| Not Available |
| Synonyms
|
- V-ATPase 28 kDa accessory protein
- V-ATPase subunit D
- Vacuolar proton pump subunit D
|
| Gene Name
| ATP6V1D |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATPase activity, coupled to transmembrane movement of substances |
| Specific Function
| Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system |
| GO Classification
|
| Component |
| proton-transporting two-sector atpase complex, catalytic domain |
| macromolecular complex |
| protein complex |
| Function |
| active transmembrane transporter activity |
| primary active transmembrane transporter activity |
| p-p-bond-hydrolysis-driven transmembrane transporter activity |
| atpase activity, coupled to transmembrane movement of substances |
| proton-transporting atpase activity, rotational mechanism |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| cation transmembrane transporter activity |
| inorganic cation transmembrane transporter activity |
| monovalent inorganic cation transmembrane transporter activity |
| hydrogen ion transmembrane transporter activity |
| transporter activity |
| Process |
| purine nucleotide metabolic process |
| purine nucleotide biosynthetic process |
| purine nucleoside triphosphate biosynthetic process |
| purine ribonucleoside triphosphate biosynthetic process |
| metabolic process |
| nitrogen compound metabolic process |
| cellular nitrogen compound metabolic process |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| nucleobase, nucleoside and nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| nucleotide metabolic process |
| atp synthesis coupled proton transport |
| atp biosynthetic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 14q23-q24.2 |
| SNPs
| ATP6V1D |
| Gene Sequence
|
>744 bp
ATGTCGGGCAAAGACCGAATTGAAATCTTTCCCTCGCGAATGGCACAGACCATCATGAAG
GCTCGTTTAAAGGGAGCACAGACAGGTCGAAACCTCCTGAAGAAAAAATCTGATGCCTTA
ACTCTTCGATTTCGACAGATCCTAAAGAAGATAATAGAGACTAAAATGTTGATGGGCGAA
GTGATGAGAGAAGCTGCCTTTTCACTAGCTGAAGCCAAGTTCACAGCAGGTGACTTCAGC
ACTACAGTTATCCAAAATGTCAATAAAGCGCAAGTGAAGATTCGAGCGAAGAAAGATAAT
GTAGCAGGTGTTACTTTGCCAGTATTTGAACATTACCATGAAGGAACTGACAGTTATGAA
CTGACTGGTTTAGCCAGAGGTGGGGAACAGTTGGCTAAATTAAAGAGGAATTATGCCAAA
GCAGTGGAACTACTGGTGGAACTAGCTTCTCTGCAGACTTCTTTTGTTACTTTGGATGAA
GCTATTAAGATAACCAACAGGCGTGTAAATGCCATTGAACATGTCATCATTCCCCGGATT
GAACGTACTCTTGCTTATATCATCACAGAGCTGGATGAGAGAGAGCGAGAAGAGTTCTAT
AGGTTAAAGAAAATACAAGAGAAGAAAAAGATTCTAAAGGAAAAATCTGAGAAGGACTTG
GAGCAAAGGAGAGCAGCTGGAAGGTGTTGGAGCCTGCTAATCTTCTTGGCTGAAGAGAAG
GACGAGGATCTTCTATTTGAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 247 |
| Molecular Weight
| 28262.5 |
| Theoretical pI
| 10.01 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>V-type proton ATPase subunit D
MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGE
VMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYE
LTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRI
ERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSEKDLEQRRAAGEVLEPANLLAEEK
DEDLLFE
|
| External Links |
|---|
| GenBank ID Protein
| 5138993 |
| UniProtKB/Swiss-Prot ID
| Q9Y5K8 |
| UniProtKB/Swiss-Prot Entry Name
| VATD_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF100741 |
| GeneCard ID
| ATP6V1D |
| GenAtlas ID
| ATP6V1D |
| HGNC ID
| HGNC:13527 |
| References |
|---|
| General References
| Not Available |