Cannabis Compound Database: Showing Protein V-type proton ATPase subunit H (CDBP02391)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP02391

Secondary Accession Numbers

Not Available

Name

V-type proton ATPase subunit H

Description

Not Available

Synonyms

NBP1
Nef-binding protein 1
V-ATPase 50/57 kDa subunits
V-ATPase subunit H
VMA13
Vacuolar proton pump subunit H
Vacuolar proton pump subunit SFD

Gene Name

ATP6V1H

Protein Type

Enzyme

Biological Properties

General Function

Involved in binding

Specific Function

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes

GO Classification

Component
proton-transporting two-sector atpase complex, catalytic domain
proton-transporting v-type atpase, v1 domain
macromolecular complex
protein complex
vacuolar proton-transporting v-type atpase, v1 domain
Function
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
hydrogen ion transmembrane transporter activity
transporter activity
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
hydrolase activity, acting on acid anhydrides
binding
catalytic activity
hydrolase activity
proton-transporting atpase activity, rotational mechanism
transmembrane transporter activity
substrate-specific transmembrane transporter activity
Process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
atp synthesis coupled proton transport
atp biosynthetic process
purine nucleotide metabolic process
purine nucleotide biosynthetic process
purine nucleoside triphosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Cellular Location

Cytoplasmic

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:8

Locus

8q11.2

SNPs

ATP6V1H

Gene Sequence

>1452 bp
ATGACCAAAATGGATATCCGAGGTGCTGTGGATGCTGCTGTCCCCACCAATATTATTGCT
GCCAAGGCTGCAGAAGTTCGTGCAAACAAAGTCAACTGGCAATCCTATCTTCAGGGACAG
ATGATTTCTGCTGAAGATTGTGAGTTTATTCAGAGGTTTGAAATGAAACGAAGCCCTGAA
GAGAAGCAAGAGATGCTTCAAACTGAAGGCAGCCAGTGTGCTAAAACATTTATAAATCTG
ATGACTCATATCTGCAAAGAACAGACCGTTCAGTATATACTAACTATGGTGGATGATATG
CTGCAGGAAAATCATCAGCGTGTTAGCATTTTCTTTGACTATGCAAGATGTAGCAAGAAC
ACTGCGTGGCCCTACTTTCTGCCAATGTTGAATCGCCAGGATCCCTTCACTGTTCATATG
GCAGCAAGAATTATTGCCAAGTTAGCAGCTTGGGGAAAAGAACTGATGGAAGGCAGTGAC
TTAAATTACTATTTCAATTGGATAAAAACTCAGCTGAGTTCACAGAAACTGCGTGGTAGC
GGTGTTGCTGTTGAAACAGGAACAGTCTCTTCAAGTGATAGTTCGCAGTATGTGCAGTGC
GTGGCCGGGTGTTTGCAGCTGATGCTCCGGGTCAATGAGTACCGCTTTGCTTGGGTGGAA
GCAGATGGGGTAAATTGCATAATGGGAGTGTTGAGTAACAAGTGTGGCTTTCAGCTCCAG
TATCAAATGATTTTTTCAATATGGCTCCTGGCATTCAGTCCTCAAATGTGTGAACACCTG
CGGCGCTATAATATCATTCCAGTTCTGTCTGATATCCTTCAGGAGTCTGTCAAAGAGAAA
GTAACAAGAATCATTCTTGCAGCATTTCGTAACTTTTTAGAAAAATCAACTGAAAGAGAA
ACTCGCCAAGAATATGCCCTGGCTATGATTCAGTGCAAAGTTCTGAAACAGTTGGAGAAC
TTGGAACAGCAGAAGTACGATGATGAAGATATCAGCGAAGATATCAAATTTCTTTTGGAA
AAACTTGGAGAGAGTGTCCAGGACCTTAGTTCATTTGATGAATACAGTTCAGAACTTAAA
TCTGGAAGGTTGGAATGGAGTCCTGTGCACAAATCTGAGAAATTTTGGAGAGAGAATGCT
GTGAGGTTAAATGAGAAGAATTATGAACTCTTGAAAATCTTGACAAAACTTTTGGAAGTG
TCAGATGATCCCCAAGTCTTAGCTGTTGCTGCTCACGATGTTGGAGAATATGTGCGGCAT
TATCCACGAGGCAAACGGGTCATCGAGCAGCTCGGTGGGAAGCAGCTGGTCATGAACCAC
ATGCATCATGAAGACCAGCAGGTCCGCTATAATGCTCTGCTGGCCGTGCAGAAGCTCATG
GTGCACAACTGGGAATACCTTGGCAAGCAGCTCCAGTCCGAGCAGCCCCAGACCGCTGCC
GCCCGAAGCTAA

Protein Properties

Number of Residues

483

Molecular Weight

55882.7

Theoretical pI

6.44

Pfam Domain Function

V-ATPase_H (PF03224 )
V-ATPase_H_C (PF11698 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>V-type proton ATPase subunit H
MTKMDIRGAVDAAVPTNIIAAKAAEVRANKVNWQSYLQGQMISAEDCEFIQRFEMKRSPE
EKQEMLQTEGSQCAKTFINLMTHICKEQTVQYILTMVDDMLQENHQRVSIFFDYARCSKN
TAWPYFLPMLNRQDPFTVHMAARIIAKLAAWGKELMEGSDLNYYFNWIKTQLSSQKLRGS
GVAVETGTVSSSDSSQYVQCVAGCLQLMLRVNEYRFAWVEADGVNCIMGVLSNKCGFQLQ
YQMIFSIWLLAFSPQMCEHLRRYNIIPVLSDILQESVKEKVTRIILAAFRNFLEKSTERE
TRQEYALAMIQCKVLKQLENLEQQKYDDEDISEDIKFLLEKLGESVQDLSSFDEYSSELK
SGRLEWSPVHKSEKFWRENAVRLNEKNYELLKILTKLLEVSDDPQVLAVAAHDVGEYVRH
YPRGKRVIEQLGGKQLVMNHMHHEDQQVRYNALLAVQKLMVHNWEYLGKQLQSEQPQTAA
ARS

External Links

GenBank ID Protein

6563196

UniProtKB/Swiss-Prot ID

Q9UI12

UniProtKB/Swiss-Prot Entry Name

VATH_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF112204

GeneCard ID