| Identification |
|---|
| HMDB Protein ID
| CDBP02376 |
| Secondary Accession Numbers
| Not Available |
| Name
| Lengsin |
| Description
| Not Available |
| Synonyms
|
- Glutamate-ammonia ligase domain-containing protein 1
- Lens glutamine synthase-like
|
| Gene Name
| LGSN |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glutamate-ammonia ligase activity |
| Specific Function
| May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity |
| GO Classification
|
| Function |
| ligase activity |
| acid-ammonia (or amide) ligase activity |
| ammonia ligase activity |
| glutamate-ammonia ligase activity |
| ligase activity, forming carbon-nitrogen bonds |
| catalytic activity |
| Process |
| metabolic process |
| nitrogen compound metabolic process |
| cellular metabolic process |
| glutamine metabolic process |
| glutamine family amino acid metabolic process |
| glutamine biosynthetic process |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6pter-q22.33 |
| SNPs
| LGSN |
| Gene Sequence
|
>1530 bp
ATGAATAATGAAGAGGACCTTCTGCAGGAGGACTCAACAAGAGATGAAGGCAATGAGACT
GAAGCCAACAGCATGAACACATTAAGAAGGACAAGGAAGAAAGTCACTAAACCATATGTT
TGTTCAACTGAAGTGGGAGAAACGGATATGTCCAATTCAAATGATTGCATGAGGGACAGC
AGTCAAATTTTGACCCCACCTCAACTCTCTTCTAGAATGAAACACATTAGACAAGCCATG
GCCAAAAATCGCCTCCAGTTTGTACGATTTGAAGCAACAGACCTCCACGGCGTGTCCAGG
TCTAAGACTATCCCTGCACACTTTTTTCAAGAGAAAGTGAGCCATGGTGTTTGCATGCCC
CGAGGTTATCTTGAAGTGATACCAAATCCAAAGGACAATGAAATGAATAACATAAGAGCC
ACATGTTTTAATAGCGACATAGTCCTAATGCCAGAGTTATCAACCTTTAGAGTTTTGCCA
TGGGCTGACAGAACTGCAAGAGTGATATGTGATACCTTCACTGTGACTGGTGAGCCTCTT
TTGACTTCCCCAAGGTACATTGCAAAGAGGCAGCTGAGCCATCTGCAGGCCTCTGGCTTT
TCCCTGCTTTCTGCTTTCATCTATGATTTTTGCATTTTTGGTGTGCCCGAAATTTTAAAT
TCAAAGATTATATCTTTTCCTGCTTTAACATTTTTAAATAACCATGATCAGCCCTTCATG
CAGGAACTTGTTGATGGCTTGTATCACACTGGAGCCAATGTCGAGAGTTTTTCCTCCTCT
ACCAGGCCTGGTCAGATGGAAATCTCTTTCCTGCCTGAATTTGGCATTAGCTCAGCTGAT
AATGCATTTACCCTCAGAACAGGTGTCAAAGAAGTGGCAAGGAAATATAATTACATTGCC
AGCTTCTTCATTGAGACTGGATTTTGTGATTCAGGGATTTTGTCTCATAGTCTCTGGGAT
GTCGATAGGAAGAAAAACATGTTCTGCAGCACTTCTGGAACTGAGCAGCTCACGATCACT
GGGAAAAAATGGTTGGCAGGACTCTTGAAGCACTCTGCTGCGCTCAGCTGCCTGATGGCG
CCTTCTGTTAGCTGCCGAAAGCGTTATTCCAAGGACAGGAAAGACCTGAAGAAGAGTGTG
CCTACAACATGGGGATACAATGACAACAGCTGTATATTTAATATCAAATGTCATGGAGAG
AAAGGCACCCGGATAGAAAATAAACTAGGCTCAGCAACAGCAAACCCTTACTTGGTGCTG
GCTGCAACTGTTGCTGCCGGCTTAGATGGACTTCATAGCAGTAATGAGGTCTTGGCTGGT
CCAGATGAGAGCACAGACTTTTACCAAGTGGAACCTTCTGAGATCCCTTTAAAACTAGAA
GATGCCCTTGTGGCACTGGAAGAAGATCAATGCCAGAGACAGGCTCTAGGAGAAACCTTT
ATTCGATATTTTGTTGCCATGAAGAAATATGAGTTGGAGAATGAAGAAATAGCTGCAGAG
AGAAATAAATTCTTAGAGTATTTTATTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 509 |
| Molecular Weight
| 57277.5 |
| Theoretical pI
| 6.3 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Lengsin
MNNEEDLLQEDSTRDEGNETEANSMNTLRRTRKKVTKPYVCSTEVGETDMSNSNDCMRDS
SQILTPPQLSSRMKHIRQAMAKNRLQFVRFEATDLHGVSRSKTIPAHFFQEKVSHGVCMP
RGYLEVIPNPKDNEMNNIRATCFNSDIVLMPELSTFRVLPWADRTARVICDTFTVTGEPL
LTSPRYIAKRQLSHLQASGFSLLSAFIYDFCIFGVPEILNSKIISFPALTFLNNHDQPFM
QELVDGLYHTGANVESFSSSTRPGQMEISFLPEFGISSADNAFTLRTGVKEVARKYNYIA
SFFIETGFCDSGILSHSLWDVDRKKNMFCSTSGTEQLTITGKKWLAGLLKHSAALSCLMA
PSVSCRKRYSKDRKDLKKSVPTTWGYNDNSCIFNIKCHGEKGTRIENKLGSATANPYLVL
AATVAAGLDGLHSSNEVLAGPDESTDFYQVEPSEIPLKLEDALVALEEDQCLRQALGETF
IRYFVAMKKYELENEEIAAERNKFLEYFI
|
| External Links |
|---|
| GenBank ID Protein
| 7341339 |
| UniProtKB/Swiss-Prot ID
| Q5TDP6 |
| UniProtKB/Swiss-Prot Entry Name
| LGSN_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF242388 |
| GeneCard ID
| LGSN |
| GenAtlas ID
| LGSN |
| HGNC ID
| HGNC:21016 |
| References |
|---|
| General References
| Not Available |