Cannabis Compound Database: Showing Protein Purine nucleoside phosphorylase (CDBP02367)

Identification Biological properties Gene properties Protein properties External links References XML Show 16 compounds

Identification

HMDB Protein ID

CDBP02367

Secondary Accession Numbers

Not Available

Name

Purine nucleoside phosphorylase

Description

Not Available

Synonyms

Inosine phosphorylase
PNP
Inosine-guanosine phosphorylase

Gene Name

PNP

Protein Type

Enzyme

Biological Properties

General Function

Involved in purine-nucleoside phosphorylase activity

Specific Function

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

GO Classification

Biological Process
purine nucleobase metabolic process
purine nucleotide catabolic process
positive regulation of T cell proliferation
purine-containing compound salvage
response to drug
immune response
inosine catabolic process
NAD biosynthesis via nicotinamide riboside salvage pathway
nicotinamide riboside catabolic process
urate biosynthetic process
positive regulation of alpha-beta T cell differentiation
interleukin-2 secretion
Cellular Component
cytoskeleton
cytosol
Function
catalytic activity
transferase activity
transferase activity, transferring pentosyl groups
transferase activity, transferring glycosyl groups
purine-nucleoside phosphorylase activity
Molecular Function
nucleoside binding
purine nucleobase binding
purine-nucleoside phosphorylase activity
drug binding
phosphate ion binding
Process
nucleoside metabolic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process

Cellular Location

Cytoplasm
cytoskeleton

Pathways

Name	SMPDB/Pathwhiz	KEGG
purine nucleoside salvage	Not Available	Not Available
Purine Metabolism
Adenosine Deaminase Deficiency		Not Available
Adenylosuccinate Lyase Deficiency		Not Available
Gout or Kelley-Seegmiller Syndrome		Not Available

Gene Properties

Chromosome Location

Locus

14q13.1

SNPs

PNP

Gene Sequence

>870 bp
ATGGAGAACGGATACACCTATGAAGATTATAAGAACACTGCAGAATGGCTTCTGTCTCAT
ACTAAGCACCGACCTCAAGTTGCAATAATCTGTGGTTCTGGATTAGGAGGTCTGACTGAT
AAATTAACTCAGGCCCAGATCTTTGACTACAGTGAAATCCCCAACTTTCCTCGAAGTACA
GTGCCAGGTCATGCTGGCCGACTGGTGTTTGGGTTCCTGAATGGCAGGGCCTGTGTGATG
ATGCAGGGCAGGTTCCACATGTATGAAGGGTACCCACTCTGGAAGGTGACATTCCCAGTG
AGGGTTTTCCACCTTCTGGGTGTGGACACCCTGGTAGTCACCAATGCAGCAGGAGGGCTG
AACCCCAAGTTTGAGGTTGGAGATATCATGCTGATCCGTGACCATATCAACCTACCTGGT
TTCAGTGGTCAGAACCCTCTCAGAGGGCCCAATGATGAAAGGTTTGGAGATCGTTTCCCT
GCCATGTCTGATGCCTACGACCGGACTATGAGGCAGAGGGCTCTCAGTACCTGGAAACAA
ATGGGGGAGCAACGTGAGCTACAGGAAGGCACCTATGTGATGGTGGCAGGCCCCAGCTTT
GAGACTGTGGCAGAATGTCGTGTGCTGCAGAAGCTGGGAGCAGACGCTGTTGGCATGAGT
ACAGTACCAGAAGTTATCGTTGCACGGCACTGTGGACTTCGAGTCTTTGGCTTCTCACTC
ATCACTAACAAGGTCATCATGGATTATGAAAGCCTGGAGAAGGCCAACCATGAAGAAGTC
TTAGCAGCTGGCAAACAAGCTGCACAGAAATTGGAACAGTTTGTCTCCATTCTTATGGCC
AGCATTCCACTCCCTGACAAAGCCAGTTGA

Protein Properties

Number of Residues

289

Molecular Weight

32117.69

Theoretical pI

6.943

Pfam Domain Function

PNP_UDP_1 (PF01048 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Purine nucleoside phosphorylase
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS

External Links

GenBank ID Protein

35565

UniProtKB/Swiss-Prot ID

P00491

UniProtKB/Swiss-Prot Entry Name

PNPH_HUMAN

PDB IDs