| Identification |
|---|
| HMDB Protein ID
| CDBP02362 |
| Secondary Accession Numbers
| Not Available |
| Name
| 4-hydroxybenzoate polyprenyltransferase, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- COQ2 homolog
- PHB:polyprenyltransferase
- hCOQ2
- Para-hydroxybenzoate--polyprenyltransferase
|
| Gene Name
| COQ2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in prenyltransferase activity |
| Specific Function
| Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB.
|
| GO Classification
|
| Biological Process |
| glycerol metabolic process |
| isoprenoid biosynthetic process |
| ubiquinone biosynthetic process |
| Cellular Component |
| mitochondrial membrane |
| integral to membrane |
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| transferase activity, transferring alkyl or aryl (other than methyl) groups |
| prenyltransferase activity |
| catalytic activity |
| transferase activity |
| Molecular Function |
| 4-hydroxybenzoate decaprenyltransferase activity |
| 4-hydroxybenzoate nonaprenyltransferase activity |
| Process |
| metabolic process |
| biosynthetic process |
|
| Cellular Location
|
- Mitochondrion membrane
- Multi-pass membrane protein (Probable)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Ubiquinone Biosynthesis |    |  | | Ubiquinone and other terpenoid-quinone biosynthesis | Not Available | |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4q21.23 |
| SNPs
| COQ2 |
| Gene Sequence
|
>1116 bp
ATGCTGGGCTCGCGAGCCGCGGGGTTCGCGCGGGGCCTGCGGGCTTTGGCACTGGCGTGG
CTGCCGGGCTGGCGGGGCCGCTCCTTCGCCCTGGCGCGTGCGGCAGGCGCGCCCCACGGT
GGTGACTTGCAGCCCCCCGCCTGTCCCGAGCCGCGCGGGCGCCAGCTCAGTTTGTCCGCG
GCGGCGGTGGTGGACTCTGCGCCCCGCCCCCTGCAGCCGTACTTGCGCCTCATGCGGTTG
GACAAGCCCATTGGAACCTGGCTTCTGTATTTACCATGTACCTGGAGCATTGGTTTGGCA
GCTGAACCAGGTTGTTTTCCAGATTGGTACATGCTCTCCCTCTTTGGCACTGGAGCTATT
CTGATGCGTGGAGCAGGCTGTACTATTAATGACATGTGGGACCAGGACTATGATAAAAAG
GTTACAAGAACAGCCAATCGTCCAATAGCCGCTGGAGACATTTCAACTTTTCAGTCCTTT
GTTTTTCTTGGGGGACAGCTAACCCTGGCACTGGGTGTTCTTCTGTGTCTAAATTACTAC
AGTATAGCTCTGGGAGCAGGATCCTTACTTCTTGTCATCACCTACCCACTAATGAAAAGA
ATTTCATACTGGCCTCAACTAGCCTTGGGCTTGACATTTAATTGGGGAGCGTTACTTGGA
TGGTCTGCTATCAAGGGTTCCTGTGATCCATCTGTTTGCCTGCCTCTTTATTTTTCTGGA
GTTATGTGGACACTAATATATGACACTATTTATGCCCATCAGGACAAAAGAGATGATGTT
TTGATTGGTCTTAAGTCAACGGCTCTGCGGTTCGGAGAAAATACCAAGCCGTGGCTCAGC
GGCTTCAGTGTTGCAATGCTGGGGGCACTGAGCCTAGTGGGTGTGAACAGTGGACAGACT
GCTCCCTACTACGCTGCCCTGGGTGCTGTAGGAGCCCATCTGACTCACCAGATTTACACT
CTAGACATCCACAGACCTGAGGATTGTTGGAATAAATTTATCTCCAACCGAACACTGGGA
CTAATAGTTTTTTTAGGGATTGTCCTTGGGAATTTGTGGAAAGAAAAGAAGACAGACAAA
ACAAAGAAGGGTATAGAGAATAAAATAGAAAATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 371 |
| Molecular Weight
| 45593.67 |
| Theoretical pI
| 9.586 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Para-hydroxybenzoate--polyprenyltransferase, mitochondrial
MLGSRAAGFARGLRALALAWLPGWRGRSFALARAAGAPHGGDLQPPACPEPRGRQLSLSA
AAVVDSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGTGAI
LMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLNYY
SIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCDPSVCLPLYFSG
VMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQT
APYYAALGAVGAHLTHQIYTLDIHRPEDCWNKFISNRTLGLIVFLGIVLGNLWKEKKTDK
TKKGIENKIEN
|
| External Links |
|---|
| GenBank ID Protein
| 14250676 |
| UniProtKB/Swiss-Prot ID
| Q96H96 |
| UniProtKB/Swiss-Prot Entry Name
| COQ2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC008804 |
| GeneCard ID
| COQ2 |
| GenAtlas ID
| COQ2 |
| HGNC ID
| HGNC:25223 |
| References |
|---|
| General References
| Not Available |