Cannabis Compound Database: Showing Protein Low affinity cationic amino acid transporter 2 (CDBP02350)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP02350

Secondary Accession Numbers

Not Available

Name

Low affinity cationic amino acid transporter 2

Description

Not Available

Synonyms

CAT-2
CAT2
Solute carrier family 7 member 2

Gene Name

SLC7A2

Protein Type

Enzyme

Biological Properties

General Function

Involved in transport

Specific Function

Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Plays a regulatory role in classical or alternative activation of macrophages

GO Classification

Component
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
active transmembrane transporter activity
transmembrane transporter activity
amine transmembrane transporter activity
amino acid transmembrane transporter activity
transporter activity
Process
amine transport
amino acid transport
transmembrane transport
establishment of localization
transport

Cellular Location

Membrane
Multi-pass membrane protein

Pathways

Name	SMPDB/Pathwhiz	KEGG
Lysine Degradation
Saccharopinuria/Hyperlysinemia II		Not Available
Hyperlysinemia I, Familial		Not Available
Hyperlysinemia II or Saccharopinuria		Not Available
Pyridoxine dependency with seizures		Not Available

Gene Properties

Chromosome Location

Chromosome:8

Locus

8p22-p21.3

SNPs

SLC7A2

Gene Sequence

>1977 bp
ATGATTCCTTGCAGAGCCGCGCTGACCTTTGCCCGATGTCTGATCCGGAGAAAAATCGTG
ACCCTGGACAGTCTAGAAGACACCAAATTATGCCGCTGCTTATCCACCATGGACCTCATT
GCCCTGGGCGTTGGAAGCACCCTTGGGGCCGGGGTTTATGTCCTCGCTGGGGAGGTGGCC
AAGGCAGACTCGGGCCCCAGCATCGTGGTGTCCTTCCTCATTGCTGCCCTGGCTTCAGTG
ATGGCTGGCCTCTGCTATGCCGAATTTGGGGCCCGTGTTCCCAAGACGGGGTCTGCATAT
TTGTACACCTACGTGACTGTCGGAGAGCTGTGGGCCTTCATCACTGGCTGGAATCTCATT
TTATCGTATGTGATAGGTACATCAAGTGTTGCAAGAGCCTGGAGTGGCACCTTTGATGAA
CTTCTTAGCAAACAGATTGGTCAGTTTTTGAGGACATACTTCAGAATGAATTACACTGGT
CTTGCAGAATATCCCGATTTTTTTGCTGTGTGCCTTATATTACTTCTAGCAGGTCTTTTG
TCTTTTGGAGTAAAAGAGTCTGCTTGGGTGAATAAAGTCTTCACAGCTGTTAATATTCTC
GTCCTTCTGTTTGTGATGGTTGCTGGGTTTGTGAAAGGAAATGTGGCAAACTGGAAGATT
AGTGAAGAGTTTCTCAAAAATATATCAGCAAGTGCCAGAGAGCCACCTTCTGAAAACGGA
ACAAGTATCTATGGGGCTGGTGGCTTTATGCCTTATGGCTTTACGGGAACGTTGGCTGGT
GCTGCAACTTGCTTTTATGCCTTTGTGGGATTTGACTGCATTGCAACAACTGGTGAAGAA
GTTCGGAATCCCCAGAAAGCTATTCCCATTGGAATTGTGACGTCTTTGCTTGTTTGCTTT
ATGGCCTATTTTGGGGTCTCTGCAGCTTTAACACTTATGATGCCGTACTACCTCCTCGAT
GAAAAAAGCCCCCTTCCTGTAGCGTTTGAATATGTGGGATGGGGTCCTGCCAAATATGTC
GTCGCAGCTGGTTCTCTCTGCGCCTTGTCAACAAGTCTTCTTGGATCCATTTTCCCAATG
CCTCGTGTAATCTATGCTATGGCGGAGGATGGGTTGCTTTTCAAATGTCTAGCTCAAATC
AATTCCAAAACGAAGACACCAATAATTGCTACTTTATCATCGGGTGCAGTGGCAGCTTTG
ATGGCCTTTCTGTTTGACCTGAAGGCGCTTGTGGACATGATGTCCATTGGCACACTCATG
GCCTACTCTCTGGTGGCAGCCTGTGTTCTCATCCTCAGGTACCAGCCTGGCTTATCTTAC
GACCAGCCCAAATGTTCTCCTGAGAAAGATGGTCTGGGATCGTCTCCCAGGGTAACCTCG
AAGAGTGAGTCCCAGGTCACCATGCTGCAGAGACAGGGCTTCAGCATGCGGACCCTCTTC
TGCCCCTCCCTTCTGCCAACACAGCAGTCAGCTTCTCTCGTGAGCTTTCTGGTAGGATTC
CTAGCTTTCCTCGTGTTGGGCCTGAGTGTCTTGACCACTTACGGAGTTCATGCCATCACC
AGGCTGGAGGCCTGGAGCCTCGCTCTCCTCGCGCTGTTTCTTGTTCTCTTCGTTGCCATC
GTTCTCACCATCTGGAGGCAGCCCCAGAATCAGCAAAAAGTAGCCTTCATGGTTCCATTC
TTACCATTTTTGCCAGCGTTCAGCATCTTGGTGAACATTTACTTGATGGTCCAGTTAAGT
GCAGACACTTGGGTCAGATTCAGCATTTGGATGGCAATTGGCTTCCTGATTTACTTTTCT
TATGGCATTAGACACAGCCTGGAGGGTCATCTGAGAGATGAAAACAATGAAGAAGATGCT
TATCCAGACAACGTTCATGCAGCAGCAGAAGAAAAATCTGCCATTCAAGCAAATGACCAT
CACCCAAGAAATCTCAGTTCACCTTTCATATTCCATGAAAAGACAAGTGAATTCTAA

Protein Properties

Number of Residues

658

Molecular Weight

71672.2

Theoretical pI

7.31

Pfam Domain Function

AA_permease (PF00324 )

Signals

["None"]

Transmembrane Regions

["38-59", "64-84", "105-125", "164-184", "193-213", "249-269", "290-309", "340-360", "387-407", "411-431", "491-511", "525-549", "558-578", "583-603"]

Protein Sequence

>Low affinity cationic amino acid transporter 2
MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA
KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI
LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLL
SFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENG
TSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCF
MAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPM
PRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLM
AYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLF
CPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAI
VLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFS
YGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF

External Links

GenBank ID Protein

258614005

UniProtKB/Swiss-Prot ID

P52569

UniProtKB/Swiss-Prot Entry Name

CTR2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_001008539.3

GeneCard ID