| Identification |
|---|
| HMDB Protein ID
| CDBP02346 |
| Secondary Accession Numbers
| Not Available |
| Name
| Choline/ethanolaminephosphotransferase 1 |
| Description
| Not Available |
| Synonyms
|
- hCEPT1
|
| Gene Name
| CEPT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphotransferase activity, for other substituted phosphate groups |
| Specific Function
| Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.
|
| GO Classification
|
| Biological Process |
| phosphatidylethanolamine biosynthetic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| nuclear membrane |
| integral to membrane |
| Component |
| membrane |
| cell part |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| phosphotransferase activity, for other substituted phosphate groups |
| Molecular Function |
| metal ion binding |
| diacylglycerol cholinephosphotransferase activity |
| ethanolaminephosphotransferase activity |
| Process |
| phospholipid metabolic process |
| metabolic process |
| phospholipid biosynthetic process |
| organophosphate metabolic process |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
- Nucleus membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycerophospholipid metabolism | Not Available |  | | Ether lipid metabolism | Not Available |  | | Plasmalogen Synthesis |    | Not Available | | Phosphatidylcholine Biosynthesis |    | Not Available | | Phosphatidylcholine Biosynthesis PC(14:0/14:0) |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p13.3 |
| SNPs
| CEPT1 |
| Gene Sequence
|
>1251 bp
ATGAGTGGGCATCGATCAACAAGGAAAAGATGTGGAGATTCTCACCCGGAGTCCCCAGTG
GGCTTCGGGCATATGAGTACTACAGGATGTGTATTAAATAAATTGTTTCAGTTACCAACA
CCACCATTGTCAAGACACCAACTAAAGCGGCTAGAAGAACACAGATATCAAAGTGCTGGA
CGGTCCCTGCTTGAGCCCTTAATGCAAGGGTATTGGGAATGGCTCGTTAGAAGAGTTCCC
TCCTGGATTGCCCCAAATCTCATCACCATCATTGGACTGTCAATAAACATCTGTACAACT
ATTTTATTAGTCTTCTACTGCCCTACAGCTACAGAGCAGGCACCTCTGTGGGCATATATT
GCTTGTGCCTGTGGCCTTTTCATTTACCAGTCTTTGGATGCTATTGATGGGAAACAGGCA
AGAAGAACCAATAGTAGTTCTCCTCTGGGAGAACTTTTTGATCATGGCTGTGATTCACTA
TCAACAGTTTTTGTGGTTCTTGGAACTTGTATTGCAGTGCAGCTGGGGACAAACCCTGAT
TGGATGTTTTTTTGTTGTTTTGCGGGGACATTTATGTTCTATTGTGCGCACTGGCAAACG
TATGTTTCTGGAACATTGCGATTTGGAATAATTGATGTGACTGAAGTGCAAATCTTCATA
ATAATCATGCATTTGCTGGCAGTGATTGGAGGACCACCTTTTTGGCAATCTATGATTCCA
GTGCTGAATATTCAAATGAAAATTTTTCCTGCACTTTGTACTGTAGCAGGGACCATATTT
TCCTGTACAAATTACTTCCGTGTAATCTTCACAGGTGGTGTTGGCAAAAATGGATCAACA
ATAGCAGGAACAAGTGTCCTTTCTCCTTTTCTCCATATTGGATCAGTGATTACATTAGCT
GCAATGATCTACAAGAAATCTGCAGTTCAGCTTTTTGAAAAGCATCCCTGTCTTTATATA
CTGACATTTGGTTTTGTGTCTGCTAAAATCACTAATAAGCTTGTGGTTGCACACATGACG
AAAAGTGAAATGCATTTGCATGACACAGCATTCATAGGTCCGGCACTTTTGTTTCTGGAC
CAGTATTTTAACAGCTTTATTGATGAATATATTGTACTTTGGATTGCCCTGGTTTTCTCT
TTCTTTGATTTGATCCGCTACTGTGTCAGTGTTTGCAATCAGATTGCGTCTCACCTGCAC
ATACATGTCTTCAGAATCAAGGTCTCTACAGCTCATTCTAATCATCATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 416 |
| Molecular Weight
| 46553.135 |
| Theoretical pI
| 8.201 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Choline/ethanolaminephosphotransferase 1
MSGHRSTRKRCGDSHPESPVGFGHMSTTGCVLNKLFQLPTPPLSRHQLKRLEEHRYQSAG
RSLLEPLMQGYWEWLVRRVPSWIAPNLITIIGLSINICTTILLVFYCPTATEQAPLWAYI
ACACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLGTNPD
WMFFCCFAGTFMFYCAHWQTYVSGTLRFGIIDVTEVQIFIIIMHLLAVIGGPPFWQSMIP
VLNIQMKIFPALCTVAGTIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPFLHIGSVITLA
AMIYKKSAVQLFEKHPCLYILTFGFVSAKITNKLVVAHMTKSEMHLHDTAFIGPALLFLD
QYFNSFIDEYIVLWIALVFSFFDLIRYCVSVCNQIASHLHIHVFRIKVSTAHSNHH
|
| External Links |
|---|
| GenBank ID Protein
| 4584877 |
| UniProtKB/Swiss-Prot ID
| Q9Y6K0 |
| UniProtKB/Swiss-Prot Entry Name
| CEPT1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF068302 |
| GeneCard ID
| CEPT1 |
| GenAtlas ID
| CEPT1 |
| HGNC ID
| HGNC:24289 |
| References |
|---|
| General References
| Not Available |