| Identification |
|---|
| HMDB Protein ID
| CDBP02342 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sodium-coupled neutral amino acid transporter 2 |
| Description
| Not Available |
| Synonyms
|
- Amino acid transporter A2
- Protein 40-9-1
- Solute carrier family 38 member 2
- System A amino acid transporter 2
- System A transporter 1
- System N amino acid transporter 2
|
| Gene Name
| SLC38A2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q |
| SNPs
| SLC38A2 |
| Gene Sequence
|
>1521 bp
ATGAAGAAGGCCGAAATGGGACGATTCAGTATTTCCCCGGATGAAGACAGCAGCAGCTAC
AGTTCCAACAGCGACTTCAACTACTCCTACCCCACCAAGCAAGCTGCTCTGAAAAGCCAT
TATGCAGATGTAGATCCTGAAAACCAGAACTTTTTACTTGAATCGAATTTGGGGAAGAAG
AAGTATGAAACAGAATTTCATCCAGGTACTACTTCCTTTGGAATGTCAGTATTTAATCTG
AGCAATGCGATTGTGGGCAGTGGAATCCTTGGGCTTTCTTATGCCATGGCTAATACTGGA
ATTGCTCTTTTTATAATTCTCTTGACATTTGTGTCAATATTTTCCCTGTATTCTGTTCAT
CTCCTTTTGAAGACTGCCAATGAAGGAGGGTCTTTATTATATGAACAATTGGGATATAAG
GCATTTGGATTAGTTGGAAAGCTTGCAGCATCTGGATCAATTACAATGCAGAACATTGGA
GCTATGTCAAGCTACCTCTTCATAGTGAAATATGAGTTGCCTTTGGTGATCCAGGCATTA
ACGAACATTGAAGATAAAACTGGATTGTGGTATCTGAACGGGAACTATTTGGTTCTGTTG
GTGTCATTGGTGGTCATTCTTCCTTTGTCGCTGTTTAGAAATTTAGGATATTTGGGATAT
ACCAGTGGCCTTTCCTTGTTGTGTATGGTGTTCTTTCTGATTGTGGTCATTTGCAAGAAA
TTTCAGGTTCCGTGTCCTGTGGAAGCTGCTTTGATAATTAACGAAACAATAAACACCACC
TTAACACAGCCAACAGCTCTTGTACCTGCTTTGTCACATAACGTGACTGAAAATGACTCT
TGCAGACCTCACTATTTTATTTTCAACTCACAGACTGTCTATGCTGTGCCAATTCTGATC
TTTTCATTTGTCTGTCATCCTGCTGTTCTTCCCATCTATGAAGAACTGAAAGACCGCAGC
CGTAGAAGAATGATGAATGTGTCCAAGATTTCATTTTTTGCTATGTTTCTCATGTATCTG
CTTGCCGCCCTCTTTGGATACCTAACATTTTACGAACATGTTGAGTCAGAATTGCTTCAT
ACCTACTCTTCTATCTTGGGAACTGATATTCTTCTTCTCATTGTCCGTCTGGCTGTGTTA
ATGGCTGTGACCCTGACAGTACCAGTAGTTATTTTCCCAATCCGGAGTTCTGTAACTCAC
TTGTTGTGTGCATCAAAAGATTTCAGTTGGTGGCGTCATAGTCTCATTACAGTGTCTATC
TTGGCATTTACCAATTTACTTGTCATCTTTGTCCCAACTATTAGGGATATCTTTGGTTTT
ATTGGTGCATCTGCAGCTTCTATGTTGATTTTTATTCTTCCTTCTGCCTTCTATATCAAG
TTGGTGAAGAAAGAACCTATGAAATCTGTACAAAAGATTGGGGCTTTGTTCTTCCTGTTA
AGTGGTGTACTGGTGATGACCGGAAGCATGGCCTTGATTGTTTTGGATTGGGTACACAAT
GCACCTGGAGGTGGCCATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 506 |
| Molecular Weight
| 56025.4 |
| Theoretical pI
| 8.12 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["77-97", "103-123", "159-179", "189-209", "218-238", "293-313", "330-350", "372-392", "414-434", "437-457", "475-495"]
|
| Protein Sequence
|
>Sodium-coupled neutral amino acid transporter 2
MKKAEMGRFSISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKK
KYETEFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVH
LLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIGAMSSYLFIVKYELPLVIQAL
TNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGYTSGLSLLCMVFFLIVVICKK
FQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDSCRPHYFIFNSQTVYAVPILI
FSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYEHVESELLH
TYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTHLLCASKDFSWWRHSLITVSI
LAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIKLVKKEPMKSVQKIGALFFLL
SGVLVMTGSMALIVLDWVHNAPGGGH
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q96QD8 |
| UniProtKB/Swiss-Prot Entry Name
| S38A2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF259799 |
| GeneCard ID
| SLC38A2 |
| GenAtlas ID
| SLC38A2 |
| HGNC ID
| HGNC:13448 |
| References |
|---|
| General References
| Not Available |