| Identification |
|---|
| HMDB Protein ID
| CDBP02335 |
| Secondary Accession Numbers
| Not Available |
| Name
| Heparan-sulfate 6-O-sulfotransferase 3 |
| Description
| Not Available |
| Synonyms
|
- HS6ST-3
|
| Gene Name
| HS6ST3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sulfotransferase activity |
| Specific Function
| 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
|
| GO Classification
|
| Cellular Component |
| integral to membrane |
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring sulfur-containing groups |
| sulfotransferase activity |
| Molecular Function |
| sulfotransferase activity |
| Process |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
| carbohydrate biosynthetic process |
|
| Cellular Location
|
- Membrane
- Single-pass type II membrane protein (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycosaminoglycan biosynthesis - heparan sulfate / heparin | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| 13q32.1 |
| SNPs
| HS6ST3 |
| Gene Sequence
|
>1416 bp
ATGGATGAAAGGTTCAACAAGTGGCTGCTGACGCCGGTGCTCACTCTCCTCTTCGTGGTC
ATCATGTACCAGTACGTGTCCCCCTCCTGCACCAGCTCCTGCACCAACTTGGGGGAGCAG
CCCCGCGCGGGGGAGGCCGGCCCGCCCGCCGTCCCGGGTCCCGCCCGCCGGGCTCAGGCG
CCGCCGGAGGAGTGGGAGCGGCGGCCCCAGTTGCCCCCGCCGCCCCGGGGGCCCCCCGAG
GGACCTCGGGGGGCCSCGGCGCCGGAGGAGGAGGACGAGGAGCCCGGAGACCCCCGGGAG
GGGGAGGAAGAGGAGGAGGAAGACGAGCCGGACCCCGAGGCCCCGGAAAACGGCTCCCTG
CCCCGATTCGTGCCGCGCTTCAACTTCAGCCTGAAGGACCTGACCCGCTTCGTGGATTTC
AACATCAAAGGGCGCGACGTGATCGTGTTCCTCCACATCCAGAAGACGGGGGGCACCACT
TTCGGCCGGCACCTGGTGAAGAACATCCGGCTGGAGCAGCCTTGTAGCTGCAAAGCGGGT
CAGAAGAAGTGCACCTGCCACCGGCCTGGCAAGAAGGAGACGTGGCTCTTCTCCCGCTTC
TCCACCGGCTGGAGCTGCGGGCTGCACGCCGACTGGACGGAGCTCACCAACTGCGTGCCG
GCCATCATGGAGAAGAAGGACTGTCCCCGCAACCACAGCCACACCAGGAATTTCTATTAC
ATCACAATGTTACGGGATCCAGTGTCACGTTACCTGAGCGAGTGGAAACATGTCCAGAGA
GGGGCCACTTGGAAAACCTCTCTTCATATGTGTGATGGAAGAAGCCCCACCCCAGATGAG
CTGCCTACCTGCTACCCTGGGGATGACTGGTCTGGGGTCAGCTTGCGGGAGTTTATGGAT
TGCACCTACAACCTGGCTAACAATCGCCAGGTGCGCATGCTGGCTGACCTCAGCCTGGTG
GGCTGCTATAACTTGACTTTCATGAACGAGAGTGAAAGAAACACCATCCTGTTGCAGAGT
GCAAAGAACAACCTGAAGAACATGGCCTTCTTTGGGCTCACTGAGTTCCAGAGGAAGACA
CAGTTTCTCTTTGAGAGAACATTCAACCTCAAGTTCATCTCCCCCTTCACACAGTTCAAC
ATCACGCGGGCTTCTAACGTGGAGATCAACGAGGGTGCCCGCCAACGCATTGAGGATCTA
AACTTCCTGGACATGCAGCTTTACGAGTATGCAAAAGATCTCTTCCAGCAGCGCTACCAC
CACACCAAGCAGCTAGAGCACCAGAGGGACCGCCAGAAGCGGCGGGAGGAGCGGAGGCTG
CAGCGAGAGCACAGGGACCACCAGTGGCCCAAAGAAGATGGGGCTGCAGAAGGGACTGTC
ACCGAGGACTACAACAGCCAGGTGGTGAGATGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 471 |
| Molecular Weight
| 54843.27 |
| Theoretical pI
| 6.835 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Heparan-sulfate 6-O-sulfotransferase 3
MDERFNKWLLTPVLTLLFVVIMYQYVSPSCTSSCTNFGEQPRAGEAGPPAVPGPARRAQA
PPEEWERRPQLPPPPRGPPEGPRGAAAPEEEDEEPGDPREGEEEEEEDEPDPEAPENGSL
PRFVPRFNFSLKDLTRFVDFNIKGRDVIVFLHIQKTGGTTFGRHLVKNIRLEQPCSCKAG
QKKCTCHRPGKKETWLFSRFSTGWSCGLHADWTELTNCVPAIMEKKDCPRNHSHTRNFYY
ITMLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTPDELPTCYPGDDWSGVSLREFMD
CTYNLANNRQVRMLADLSLVGCYNLTFMNESERNTILLQSAKNNLKNMAFFGLTEFQRKT
QFLFERTFNLKFISPFTQFNITRASNVEINEGARQRIEDLNFLDMQLYEYAKDLFQQRYH
HTKQLEHQRDRQKRREERRLQREHRDHQWPKEDGAAEGTVTEDYNSQVVRW
|
| External Links |
|---|
| GenBank ID Protein
| 23452527 |
| UniProtKB/Swiss-Prot ID
| Q8IZP7 |
| UniProtKB/Swiss-Prot Entry Name
| H6ST3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF539426 |
| GeneCard ID
| HS6ST3 |
| GenAtlas ID
| HS6ST3 |
| HGNC ID
| HGNC:19134 |
| References |
|---|
| General References
| Not Available |