Cannabis Compound Database: Showing Protein Glycerol-3-phosphate acyltransferase 4 (CDBP02331)

Identification Biological properties Gene properties Protein properties External links References XML Show 8 compounds

Identification

HMDB Protein ID

CDBP02331

Secondary Accession Numbers

Not Available

Name

Glycerol-3-phosphate acyltransferase 4

Description

Not Available

Synonyms

1-AGP acyltransferase 6
1-AGPAT 6
1-acylglycerol-3-phosphate O-acyltransferase 6
Acyl-CoA:glycerol-3-phosphate acyltransferase 4
GPAT4
LPAAT-zeta
Lysophosphatidic acid acyltransferase zeta

Gene Name

AGPAT6

Protein Type

Enzyme

Biological Properties

General Function

Involved in acyltransferase activity

Specific Function

Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs.

GO Classification

Biological Process
acyl-CoA metabolic process
CDP-diacylglycerol biosynthetic process
phosphatidylcholine biosynthetic process
fatty acid metabolic process
regulation of multicellular organism growth
phosphatidic acid biosynthetic process
diacylglycerol metabolic process
triglyceride biosynthetic process
lactation
glandular epithelial cell maturation
Cellular Component
endoplasmic reticulum membrane
integral to membrane
Function
acyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
Molecular Function
glycerol-3-phosphate O-acyltransferase activity
Process
metabolic process

Cellular Location

Endoplasmic reticulum membrane
Multi-pass membrane protein

Pathways

Name	SMPDB/Pathwhiz	KEGG
CDP-diacylglycerol biosynthesis	Not Available	Not Available
Glycerophospholipid metabolism	Not Available

Gene Properties

Chromosome Location

Locus

8p11.21

SNPs

AGPAT6

Gene Sequence

>1371 bp
ATGTTCCTGTTGCTGCCTTTTGATAGCCTGATTGTCAACCTTCTGGGCATCTCCCTGACT
GTCCTCTTCACCCTCCTTCTCGTTTTCATCATAGTGCCAGCCATTTTTGGAGTCTCCTTT
GGTATCCGCAAACTCTACATGAAAAGTCTGTTAAAAATCTTTGCGTGGGCTACCTTGAGA
ATGGAGCGAGGAGCCAAGGAGAAGAACCACCAGCTTTACAAGCCCTACACCAACGGAATC
ATTGCAAAGGATCCCACTTCACTAGAAGAAGAGATCAAAGAGATTCGTCGAAGTGGTAGT
AGTAAGGCTCTGGACAACACTCCAGAGTTCGAGCTCTCTGACATTTTCTACTTTTGCCGG
AAAGGAATGGAGACCATTATGGATGATGAGGTGACAAAGAGATTCTCAGCAGAAGAACTG
GAGTCCTGGAACCTGCTGAGCAGAACCAATTATAACTTCCAGTACATCAGCCTTCGGCTC
ACGGTCCTGTGGGGGTTAGGAGTGCTGATTCGGTACTGCTTTCTGCTGCCGCTCAGGATA
GCACTGGCTTTCACAGGGATTAGCCTTCTGGTGGTGGGCACAACTGTGGTGGGATACTTG
CCAAATGGGAGGTTTAAGGAGTTCATGAGTAAACATGTTCACTTAATGTGTTACCGGATC
TGCGTGCGAGCGCTGACAGCCATCATCACCTACCATGACAGGGAAAACAGACCAAGAAAT
GGTGGCATCTGTGTGGCCAATCATACCTCACCGATCGATGTGATCATCTTGGCCAGCGAT
GGCTATTATGCCATGGTGGGTCAAGTGCACGGGGGACTCATGGGTGTGATTCAGAGAGCC
ATGGTGAAGGCCTGCCCACACGTCTGGTTTGAGCGCTCGGAAGTGAAGGATCGCCACCTG
GTGGCTAAGAGACTGACTGAACATGTGCAAGATAAAAGCAAGCTGCCTATCCTCATCTTC
CCAGAAGGAACCTGCATCAATAATACATCGGTGATGATGTTCAAAAAGGGAAGTTTTGAA
ATTGGAGCCACAGTTTACCCTGTTGCTATCAAGTATGACCCTCAATTTGGCGATGCCTTC
TGGAACAGCAGCAAATACGGGATGGTGACGTACCTGCTGCGAATGATGACCAGCTGGGCC
ATTGTCTGCAGCGTGTGGTACCTGCCTCCCATGACTAGAGAGGCAGATGAAGATGCTGTC
CAGTTTGCGAATAGGGTGAAATCTGCCATTGCCAGGCAGGGAGGACTTGTGGACCTGCTG
TGGGATGGGGGCCTGAAGAGGGAGAAGGTGAAGGACACGTTCAAGGAGGAGCAGCAGAAG
CTGTACAGCAAGATGATCGTGGGGAACCACAAGGACAGGAGCCGCTCCTGA

Protein Properties

Number of Residues

456

Molecular Weight

52070.605

Theoretical pI

9.187

Pfam Domain Function

Acyltransferase (PF01553 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Glycerol-3-phosphate acyltransferase 4
MFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYMKSLLKIFAWATLR
MERGAKEKNHQLYKPYTNGIIAKDPTSLEEEIKEIRRSGSSKALDNTPEFELSDIFYFCR
KGMETIMDDEVTKRFSAEELESWNLLSRTNYNFQYISLRLTVLWGLGVLIRYCFLLPLRI
ALAFTGISLLVVGTTVVGYLPNGRFKEFMSKHVHLMCYRICVRALTAIITYHDRENRPRN
GGICVANHTSPIDVIILASDGYYAMVGQVHGGLMGVIQRAMVKACPHVWFERSEVKDRHL
VAKRLTEHVQDKSKLPILIFPEGTCINNTSVMMFKKGSFEIGATVYPVAIKYDPQFGDAF
WNSSKYGMVTYLLRMMTSWAIVCSVWYLPPMTREADEDAVQFANRVKSAIARQGGLVDLL
WDGGLKREKVKDTFKEEQQKLYSKMIVGNHKDRSRS

External Links

GenBank ID Protein

30142570

UniProtKB/Swiss-Prot ID

Q86UL3

UniProtKB/Swiss-Prot Entry Name

GPAT4_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF406612

GeneCard ID