Showing Protein Beta-1,3-galactosyltransferase 6 (CDBP02328)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP02328
Secondary Accession Numbers Not Available
Name Beta-1,3-galactosyltransferase 6
Description Not Available
Synonyms
  1. Beta-1,3-GalTase 6
  2. Beta3Gal-T6
  3. Beta3GalT6
  4. GAG GalTII
  5. Galactosyltransferase II
  6. Galactosylxylosylprotein 3-beta-galactosyltransferase
  7. UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
Gene Name B3GALT6
Protein Type Enzyme
Biological Properties
General Function Involved in galactosyltransferase activity
Specific Function Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues.
GO Classification
Biological Process
heparan sulfate proteoglycan biosynthetic process
chondroitin sulfate biosynthetic process
glycosaminoglycan biosynthetic process
protein glycosylation
carbohydrate metabolic process
chondroitin sulfate metabolic process
Cellular Component
integral to membrane
Golgi membrane
Golgi cisterna membrane
Golgi medial cisterna
Component
membrane
cell part
Function
galactosyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring hexosyl groups
transferase activity, transferring glycosyl groups
Molecular Function
galactosylxylosylprotein 3-beta-galactosyltransferase activity
UDP-galactosyltransferase activity
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
Process
protein amino acid glycosylation
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
Cellular Location
  1. Single-pass type II membrane protein
  2. Golgi apparatus
  3. Golgi stack membrane
Pathways
Gene Properties
Chromosome Location 1
Locus 1p36.33
SNPs B3GALT6
Gene Sequence 
>990 bp
ATGAAGCTGCTGCGGCGGGCGTGGCGGCGGCGGGCGGCGCTAGGCCTGGGCACGCTGGCG
CTGTGCGGGGCGGCGCTGCTCTACCTGGCGCGCTGCGCGGCCGAGCCCGGGGACCCCAGG
GCGATGTCGGGCCGCAGCCCGCCTCCCCCCGCGCCCGCGCGCGCCGCCGCCTTCCTGGCA
GTGCTGGTGGCCAGCGCGCCCCGCGCCGCCGAGCGCCGCAGCGTGATCCGCAGCACGTGG
CTTGCGCGGCGCGGGGCCCCGGGCGACGTGTGGGCGCGCTTTGCCGTGGGCACGGCCGGC
CTGGGCGCCGAGGAGCGGCGCGCCCTGGAGCGGGAGCAGGCGCGGCACGGGGACCTGCTG
CTGCTGCCCGCGCTGCGCGACGCCTACGAAAACCTCACGGCCAAGGTGCTGGCCATGCTG
GCCTGGCTGGACGAGCACGTGGCCTTCGAGTTCGTGCTCAAGGCGGACGACGACTCCTTC
GCGCGGCTGGACGCGCTGCTGGCCGAGCTGCGCGCCCGCGAGCCCGCGCGCCGCCGCCGC
CTCTACTGGGGCTTCTTCTCGGGCCGCGGCCGCGTCAAGCCGGGGGGGCGCTGGCGCGAG
GCCGCCTGGCAACTCTGCGACTACTACCTGCCCTACGCGCTGGGCGGCGGCTACGTGCTC
TCGGCCGACCTGGTGCACTACCTGCGCCTCAGCCGCGACTACCTGCGCGCCTGGCACAGC
GAGGACGTGTCTCTGGGCGCCTGGCTGGCGCCGGTGGACGTCCAGCGGGAGCACGACCCG
CGCTTCGACACCGAATACCGGTCCCGCGGCTGCAGCAACCAGTACCTGGTGACGCACAAG
CAGAGCCTGGAGGACATGCTGGAGAAGCACGCGACGCTGGCGCGCGAGGGCCGCCTGTGC
AAGCGCGAGGTGCAGCTGCGCCTGTCCTACGTGTACGACTGGTCCGCGCCGCCCTCGCAG
TGCTGCCAGAGAAGGGAGGGCATCCCCTGA
Protein Properties
Number of Residues 329
Molecular Weight 37137.08
Theoretical pI 9.66
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Beta-1,3-galactosyltransferase 6
MKLLRRAWRRRAALGLGTLALCGAALLYLARCAAEPGDPRAMSGRSPPPPAPARAAAFLA
VLVASAPRAAERRSVIRSTWLARRGAPGDVWARFAVGTAGLGAEERRALEREQARHGDLL
LLPALRDAYENLTAKVLAMLAWLDEHVAFEFVLKADDDSFARLDALLAELRAREPARRRR
LYWGFFSGRGRVKPGGRWREAAWQLCDYYLPYALGGGYVLSADLVHYLRLSRDYLRAWHS
EDVSLGAWLAPVDVQREHDPRFDTEYRSRGCSNQYLVTHKQSLEDMLEKHATLAREGRLC
KREVQLRLSYVYDWSAPPSQCCQRREGIP
GenBank ID Protein 56206316
UniProtKB/Swiss-Prot ID Q96L58
UniProtKB/Swiss-Prot Entry Name B3GT6_HUMAN
PDB IDs Not Available
GenBank Gene ID AL162741
GeneCard ID B3GALT6
GenAtlas ID B3GALT6
HGNC ID HGNC:17978
References
General References Not Available