| Identification |
|---|
| HMDB Protein ID
| CDBP02314 |
| Secondary Accession Numbers
| Not Available |
| Name
| Uronyl 2-sulfotransferase |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| UST |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sulfotransferase activity |
| Specific Function
| Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring sulfur-containing groups |
| sulfotransferase activity |
| Process |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
| carbohydrate biosynthetic process |
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6q25.1 |
| SNPs
| UST |
| Gene Sequence
|
>1221 bp
ATGAAGAAGAAGCAGCAGCATCCCGGCGGCGGCGCGGATCCCTGGCCCCATGGGGCCCCT
ATGGGGGGCGCCCCTCCGGGCCTGGGCAGCTGGAAGCGTCGGGTGCCCCTGCTGCCTTTC
CTGCGCTTCTCCCTCCGGGACTACGGCTTCTGCATGGCCACCCTGCTGGTCTTCTGCCTG
GGCTCCCTCCTCTATCAGCTCAGCGGGGGACCCCCTCGCTTCCTGCTCGACCTGCGGCAG
TACTTGGGAAATTCCACTTACTTGGATGACCATGGACCACCTCCTAGTAAGGTACTACCT
TTCCCAAGCCAGGTGGTGTACAACAGGGTAGGCAAGTGTGGGAGCCGTACTGTGGTCTTG
CTTCTGAGAATCTTGTCGGAGAAGCACGGATTTAATTTGGTCACATCAGACATTCACAAC
AAAACCAGGCTTACTAAAAATGAACAAATGGAACTGATTAAAAATATAAGTACTGCCGAA
CAACCCTATTTATTCACTCGACATGTTCATTTCCTCAACTTCTCAAGGTTTGGAGGAGAC
CAGCCTGTCTACATCAACATCATTAGAGACCCCGTCAACCGGTTCTTATCCAACTATTTT
TTCCGTCGCTTTGGAGACTGGAGAGGGGAACAAAATCACATGATCCGCACCCCCAGCATG
AGGCAGGAGGAGCGCTACCTGGATATCAATGAGTGTATTCTTGAAAACTATCCCGAGTGC
TCCAACCCCAGGTTATTTTACATCATTCCGTACTTTTGTGGACAGCATCCCAGATGCAGG
GAGCCTGGTGAATGGGCCCTTGAGAGAGCAAAGCTGAACGTGAATGAAAACTTCCTGCTC
GTGGGGATTCTTGAAGAGTTGGAAGATGTGCTGCTGTTACTGGAAAGATTTTTACCTCAT
TACTTCAAGGGCGTGCTCAGTATCTACAAAGACCCAGAGCACAGGAAGCTTGGAAACATG
ACTGTGACGGTGAAGAAGACTGTCCCCTCTCCTGAGGCTGTGCAGATCCTCTACCAGCGG
ATGAGATACGAGTACGAGTTTTACCACTACGTCAAAGAGCAGTTCCACCTGCTGAAGCGC
AAGTTTGGACTTAAGTCTCACGTCAGCAAGCCCCCCCTGAGGCCACACTTCTTTATCCCA
ACTCCACTGGAAACCGAGGAGCCAATCGACGATGAAGAACAGGATGATGAAAAGTGGCTG
GAAGATATTTATAAGAGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 406 |
| Molecular Weight
| 47672.6 |
| Theoretical pI
| 8.89 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Uronyl 2-sulfotransferase
MKKKQQHPGGGADPWPHGAPMGGAPPGLGSWKRRVPLLPFLRFSLRDYGFCMATLLVFCL
GSLLYQLSGGPPRFLLDLRQYLGNSTYLDDHGPPPSKVLPFPSQVVYNRVGKCGSRTVVL
LLRILSEKHGFNLVTSDIHNKTRLTKNEQMELIKNISTAEQPYLFTRHVHFLNFSRFGGD
QPVYINIIRDPVNRFLSNYFFRRFGDWRGEQNHMIRTPSMRQEERYLDINECILENYPEC
SNPRLFYIIPYFCGQHPRCREPGEWALERAKLNVNENFLLVGILEELEDVLLLLERFLPH
YFKGVLSIYKDPEHRKLGNMTVTVKKTVPSPEAVQILYQRMRYEYEFYHYVKEQFHLLKR
KFGLKSHVSKPPLRPHFFIPTPLETEEPIDDEEQDDEKWLEDIYKR
|
| External Links |
|---|
| GenBank ID Protein
| 4803735 |
| UniProtKB/Swiss-Prot ID
| Q9Y2C2 |
| UniProtKB/Swiss-Prot Entry Name
| UST_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB020316 |
| GeneCard ID
| UST |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |