| Identification |
|---|
| HMDB Protein ID
| CDBP02309 |
| Secondary Accession Numbers
| Not Available |
| Name
| Gamma-glutamyl hydrolase |
| Description
| Not Available |
| Synonyms
|
- Conjugase
- GH
- Gamma-Glu-X carboxypeptidase
|
| Gene Name
| GGH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
|
| GO Classification
|
| Biological Process |
| response to zinc ion |
| glutamine metabolic process |
| response to insulin stimulus |
| response to drug |
| response to ethanol |
| Cellular Component |
| cytosol |
| melanosome |
| lysosome |
| extracellular space |
| Function |
| exopeptidase activity |
| catalytic activity |
| hydrolase activity |
| omega peptidase activity |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| Molecular Function |
| gamma-glutamyl-peptidase activity |
| Process |
| metabolic process |
| cellular metabolic process |
| glutamine metabolic process |
| glutamine family amino acid metabolic process |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
|
| Cellular Location
|
- Melanosome
- Lysosome
- Secreted
- extracellular space
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Folate biosynthesis | Not Available |  | | Folate Metabolism |    |  | | Methotrexate Action Pathway |    | Not Available | | Folate malabsorption, hereditary |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8q12.3 |
| SNPs
| GGH |
| Gene Sequence
|
>957 bp
ATGGCCAGTCCGGGCTGCCTGCTGTGCGTGCTGGGCCTGCTACTCTGCGGGGCGGCGAGC
CTCGAGCTGTCTAGACCCCACGGCGACACCGCCAAGAAGCCCATCATCGGAATATTAATG
CAAAAATGCCGTAATAAAGTCATGAAAAACTATGGAAGATACTATATTGCTGCGTCCTAT
GTAAAGTACTTGGAGTCTGCAGGTGCGAGAGTTGTACCAGTAAGGCTGGATCTTACAGAG
AAAGACTATGAAATACTTTTCAAATCTATTAATGGAATCCTTTTCCCTGGAGGAAGTGTT
GACCTCAGACGCTCAGATTATGCTAAAGTGGCCAAAATATTTTATAACTTGTCCATACAG
AGTTTTGATGATGGAGACTATTTTCCTGTGTGGGGCACATGCCTTGGATTTGAAGAGCTT
TCACTGCTGATTAGTGGAGAGTGCTTATTAACTGCCACAGATACTGTTGACGTGGCAATG
CCGCTGAACTTCACTGGAGGTCAATTGCACAGCAGAATGTTCCAGAATTTTCCTACTGAG
TTGTTGCTGTCATTAGCAGTAGAACCTCTGACTGCCAATTTCCATAAGTGGAGCCTCTCC
GTGAAGAATTTTACAATGAATGAAAAGTTAAAGAAGTTTTTCAATGTCTTAACTACAAAT
ACAGATGGCAAGATTGAGTTTATTTCAACAATGGAAGGATATAAGTATCCAGTATATGGT
GTCCAGTGGCATCCAGAGAAAGCACCTTATGAGTGGAAGAATTTGGATGGCATTTCCCAT
GCACCTAATGCTGTGAAAACCGCATTTTATTTAGCAGAGTTTTTTGTTAATGAAGCTCGG
AAAAACAACCATCATTTTAAATCTGAATCTGAAGAGGAGAAAGCATTGATTTATCAGTTC
AGTCCAATTTATACTGGAAATATTTCTTCATTTCAGCAATGTTACATATTTGATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 318 |
| Molecular Weight
| 35964.045 |
| Theoretical pI
| 7.111 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Gamma-glutamyl hydrolase
MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASY
VKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQ
SFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTE
LLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYG
VQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQF
SPIYTGNISSFQQCYIFD
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q92820 |
| UniProtKB/Swiss-Prot Entry Name
| GGH_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| U55206 |
| GeneCard ID
| GGH |
| GenAtlas ID
| GGH |
| HGNC ID
| HGNC:4248 |
| References |
|---|
| General References
| Not Available |