Cannabis Compound Database: Showing Protein Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CDBP02293)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP02293

Secondary Accession Numbers

Not Available

Name

Chondroitin sulfate N-acetylgalactosaminyltransferase 2

Description

Not Available

Synonyms

Beta4GalNAcT-2
Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2
GalNAcT-2

Gene Name

CSGALNACT2

Protein Type

Enzyme

Biological Properties

General Function

Involved in transferase activity, transferring hexosyl groups

Specific Function

Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains.

GO Classification

Biological Process
chondroitin sulfate biosynthetic process
chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
Cellular Component
Golgi cisterna membrane
integral to Golgi membrane
Component
membrane
cell part
organelle membrane
golgi cisterna membrane
golgi membrane
Function
catalytic activity
transferase activity
transferase activity, transferring hexosyl groups
transferase activity, transferring glycosyl groups
Molecular Function
acetylgalactosaminyltransferase activity
metal ion binding
glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

Cellular Location

Golgi apparatus
Golgi stack membrane
Single-pass type II membrane protein (Probable)

Pathways

Name	SMPDB/Pathwhiz	KEGG
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	Not Available

Gene Properties

Chromosome Location

Locus

10q11.21

SNPs

CSGALNACT2

Gene Sequence

>1629 bp
ATGCCTAGAAGAGGACTGATTCTTCACACCCGGACCCACTGGTTGCTGTTGGGCCTTGCT
TTGCTCTGCAGTTTGGTATTATTTATGTACCTCCTGGAATGTGCCCCCCAGACTGATGGA
AATGCATCTCTTCCTGGTGTTGTTGGGGAAAATTATGGTAAAGAGTATTATCAAGCCCTC
CTACAGGAACAAGAAGAACATTATCAGACCAGGGCAACCAGTCTGAAACGCCAAATTGCC
CAACTAAAACAAGAATTACAAGAAATGAGTGAGAAGATGCGGTCACTGCAAGAAAGAAGG
AATGTAGGGGCTAATGGCATAGGCTATCAGAGCAACAAAGAGCAAGCACCTAGTGATCTT
TTAGAGTTTCTTCATTCCCAAATTGACAAAGCTGAAGTTAGCATAGGGGCCAAACTACCC
AGTGAGTATGGGGTCATTCCCTTTGAAAGTTTTACCTTAATGAAAGTATTTCAATTGGAA
ATGGGTCTCACTCGCCATCCTGAAGAAAAGCCAGTTAGAAAAGACAAACGAGATGAATTG
GTGGAAGTTATTGAAGCGGGCTTGGAGGTCATTAATAATCCTGATGAAGATGATGAACAA
GAAGATGAGGAGGGTCCCCTTGGAGAGAAACTGATATTTAATGAAAATGACTTCGTAGAA
GGTTATTATCGCACTGAGAGAGATAAGGGCACACAGTATGAACTCTTTTTTAAGAAAGCA
GACCTTACGGAATATAGACATGTGACCCTCTTCCGCCCTTTTGGACCTCTCATGAAAGTG
AAGAGTGAGATGATTGACATCACTAGATCAATTATTAATATCATTGTGCCACTTGCTGAA
AGAACTGAAGCATTTGTACAATTTATGCAGAACTTCAGGGATGTTTGTATTCATCAAGAC
AAGAAGATTCATCTCACAGTGGTGTATTTTGGTAAAGAAGGACTGTCTAAAGTCAAGTCT
ATCCTAGAATCTGTCACCAGTGAGTCTAATTTTCACAATTACACCTTGGTCTCATTGAAT
GAAGAATTTAATCGTGGACGAGGACTAAATGTGGGTGCCCGAGCTTGGGACAAGGGAGAG
GTCTTGATGTTTTTCTGTGATGTTGATATCTATTTCTCAGCCGAATTCCTTAACAGCTGC
CGGTTAAATGCTGAGCCAGGTAAGAAGGTGTTTTACCCTGTGGTGTTCAGTCTTTACAAT
CCTGCCATTGTTTATGCCAACCAGGAAGTGCCACCACCTGTGGAGCAGCAGCTGGTTCAC
AAAAAGGATTCTGGCTTTTGGCGAGATTTTGGCTTTGGAATGACTTGTCAGTATCGTTCA
GATTTCCTGACCATTGGTGGATTTGACATGGAAGTGAAAGGTTGGGGTGGAGAAGATGTT
CATCTTTATCGAAAATACTTACATGGTGACCTCATTGTGATTCGGACTCCGGTTCCTGGT
CTTTTCCACCTCTGGCATGAAAAGCGCTGTGCTGATGAGCTGACCCCCGAGCAGTACCGC
ATGTGCATCCAGTCTAAAGCCATGAATGAGGCCTCTCACTCCCACCTGGGAATGCTGGTC
TTCAGGGAGGAAATAGAGACGCATCTTCATAAACAGGCATACAGGACAAACAGTGAAGCT
GTTGGTTGA

Protein Properties

Number of Residues

542

Molecular Weight

62571.875

Theoretical pI

5.729

Pfam Domain Function

CHGN (PF05679 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Chondroitin sulfate N-acetylgalactosaminyltransferase 2
MPRRGLILHTRTHWLLLGLALLCSLVLFMYLLECAPQTDGNASLPGVVGENYGKEYYQAL
LQEQEEHYQTRATSLKRQIAQLKQELQEMSEKMRSLQERRNVGANGIGYQSNKEQAPSDL
LEFLHSQIDKAEVSIGAKLPSEYGVIPFESFTLMKVFQLEMGLTRHPEEKPVRKDKRDEL
VEVIEAGLEVINNPDEDDEQEDEEGPLGEKLIFNENDFVEGYYRTERDKGTQYELFFKKA
DLTEYRHVTLFRPFGPLMKVKSEMIDITRSIINIIVPLAERTEAFVQFMQNFRDVCIHQD
KKIHLTVVYFGKEGLSKVKSILESVTSESNFHNYTLVSLNEEFNRGRGLNVGARAWDKGE
VLMFFCDVDIYFSAEFLNSCRLNAEPGKKVFYPVVFSLYNPAIVYANQEVPPPVEQQLVH
KKDSGFWRDFGFGMTCQYRSDFLTIGGFDMEVKGWGGEDVHLYRKYLHGDLIVIRTPVPG
LFHLWHEKRCADELTPEQYRMCIQSKAMNEASHSHLGMLVFREEIETHLHKQAYRTNSEA
VG

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

Q8N6G5

UniProtKB/Swiss-Prot Entry Name

CGAT2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AB079252

GeneCard ID