| Identification |
|---|
| HMDB Protein ID
| CDBP02285 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sodium/calcium exchanger 2 |
| Description
| Not Available |
| Synonyms
|
- Na(+)/Ca(2+)-exchange protein 2
|
| Gene Name
| SLC8A2 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in cell communication |
| Specific Function
| Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores |
| GO Classification
|
| Component |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| solute:cation antiporter activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| cation transmembrane transporter activity |
| cation:cation antiporter activity |
| calcium:cation antiporter activity |
| calcium:sodium antiporter activity |
| transporter activity |
| Process |
| calcium ion transport |
| establishment of localization |
| cellular process |
| transport |
| transmembrane transport |
| ion transport |
| cation transport |
| cell communication |
| di-, tri-valent inorganic cation transport |
| divalent metal ion transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q13.3 |
| SNPs
| SLC8A2 |
| Gene Sequence
|
>2766 bp
ATGGCTCCCCTGGCCTTGGTGGGGGTCACACTCCTCCTGGCGGCTCCCCCATGCTCCGGG
GCAGCCACCCCAACCCCCTCCCTGCCGCCTCCCCCGGCCAATGACAGCGACACCAGCACA
GGGGGCTGCCAGGGGTCCTACCGCTGCCAGCCGGGGGTGCTGCTGCCCGTGTGGGAGCCC
GACGACCCGTCGCTGGGTGACAAGGCGGCACGGGCAGTGGTGTACTTTGTGGCCATGGTC
TACATGTTTCTGGGAGTGTCCATCATCGCCGACCGTTTCATGGCGGCCATCGAGGTCATC
ACGTCAAAAGAGAAGGAGATCACCATCACCAAGGCCAACGGTGAGACCAGCGTGGGCACC
GTTCGCATCTGGAATGAGACGGTGTCCAACCTCACGCTCATGGCCCTGGGCTCCTCCGCA
CCTGAGATCCTGCTGTCAGTCATCGAAGTCTGCGGCCACAACTTCCAGGCGGGTGAGCTG
GGCCCAGGCACCATCGTGGGCAGCGCTGCCTTCAACATGTTTGTGGTCATCGCCGTGTGC
ATCTACGTCATCCCAGCCGGCGAGAGCCGCAAGATCAAGCACCTGAGAGTCTTCTTTGTC
ACTGCCTCTTGGAGCATCTTCGCCTATGTCTGGCTTTATCTCATCCTTGCTGTTTTTTCC
CCCGGTGTGGTCCAGGTGTGGGAGGCGCTGCTGACCCTGGTCTTCTTCCCGGTGTGCGTG
GTATTCGCCTGGATGGCCGACAAGCGGCTGCTCTTCTACAAGTACGTGTACAAGCGCTAC
CGCACCGACCCACGCAGCGGCATCATCATAGGCGCCGAGGGCGACCCCCCGAAGAGCATC
GAGCTGGACGGCACGTTCGTGGGCGCCGAGGCCCCAGGTGAGCTGGGCGGCCTGGGCCCG
GGCCCCGCCGAGGCGCGCGAGCTGGACGCCAGCCGCCGCGAGGTCATCCAGATCCTCAAG
GACCTCAAGCAGAAGCACCCGGACAAGGATCTGGAGCAGCTGGTGGGCATCGCCAACTAC
TACGCGCTGCTGCACCAGCAGAAGAGCCGCGCCTTCTACCGCATCCAGGCCACGCGGCTG
ATGACCGGCGCCGGGAACGTGCTGCGCAGACACGCGGCGGACGCCTCGCGCAGGGCGGCG
CCGGCCGAGGGCGCGGGCGAGGACGAAGACGACGGCGCCAGCCGCATCTTCTTCGAGCCT
AGCCTCTACCACTGCCTGGAGAACTGCGGCTCCGTGCTGCTGTCCGTCACGTGCCAGGGC
GGCGAGGGCAACAGCACCTTCTACGTGGACTACCGCACTGAGGACGGCTCTGCCAAGGCG
GGCTCCGACTACGAGTACAGCGAGGGCACGCTGGTGTTCAAACCAGGCGAGACGCAGAAG
GAGCTGCGCATCGGCATCATCGACGACGACATCTTCGAGGAGGACGAGCATTTCTTCGTG
CGGCTGCTGAACCTGCGCGTGGGCGACGCGCAGGGCATGTTCGAGCCGGACGGCGGCGGG
CGGCCCAAGGGGCGGCTGGTGGCGCCGCTGCTGGCCACCGTCACCATCCTGGACGACGAC
CACGCAGGCATCTTCTCCTTCCAGGACCGCCTGCTGCACGTGAGCGAGTGCATGGGCACC
GTGGACGTGCGCGTCGTGCGCAGCTCGGGCGCGCGCGGCACCGTGCGCCTTCCCTACCGC
ACGGTGGACGGCACGGCGCGCGGCGGCGGCGTGCACTACGAGGACGCGTGCGGAGAGCTG
GAGTTTGGCGACGACGAGACCATGAAAACTCTTCAGGTGAAGATAGTTGATGACGAGGAA
TATGAGAAAAAGGATAATTTCTTCATTGAGCTGGGCCAGCCCCAGTGGCTTAAGCGAGGG
ATTTCAGCTCTGCTACTCAATCAAGGGGATGGGGACAGGAAGCTAACAGCCGAGGAGGAG
GAGGCTCGGAGGATAGCAGAGATGGGCAAGCCAGTTCTTGGGGAGAACTGCCGGCTGGAG
GTCATCATCGAGGAGTCATATGATTTTAAGAACACGGTGGATAAACTCATCAAGAAAACG
AACTTGGCCTTGGTAATTGGGACCCATTCATGGAGGGAGCAGTTTTTAGAGGCAATTACG
GTGAGCGCAGGGGACGAGGAGGAGGAGGAGGACGGGTCCCGGGAGGAGCGGCTGCCGTCG
TGCTTTGACTACGTGATGCACTTCCTGACGGTGTTCTGGAAGGTGCTCTTCGCCTGTGTG
CCCCCCACCGAGTACTGCCACGGCTGGGCCTGCTTTGGTGTCTCCATCCTGGTCATCGGC
CTGCTCACCGCCCTCATTGGGGACCTCGCCTCCCACTTCGGCTGCACCGTTGGCCTCAAG
GACTCTGTCAATGCTGTTGTCTTCGTTGCCCTGGGCACCTCCATCCCTGACACGTTCGCC
AGCAAGGTGGCGGCGCTGCAGGACCAGTGCGCCGACGCGTCCATCGGCAACGTGACCGGC
TCCAACGCGGTGAACGTGTTCCTTGGCCTGGGCGTCGCCTGGTCTGTGGCCGCCGTGTAC
TGGGCGGTGCAGGGCCGCCCCTTCGAGGTGCGCACTGGCACGCTGGCCTTCTCCGTCACG
CTCTTCACCGTCTTCGCCTTCGTGGGCATTGCCGTGCTGCTGTACCGGCGCCGGCCGCAC
ATCGGCGGCGAGCTGGGCGGCCCGCGCGGACCCAAGCTCGCCACCACCGCGCTCTTCCTG
GGCCTCTGGCTCCTGTACATCCTCTTCGCCAGCCTGGAGGCGTACTGCCACATCCGGGGC
TTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 921 |
| Molecular Weight
| 100366.9 |
| Theoretical pI
| 4.78 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["69-90", "131-152", "165-185", "197-219", "223-246", "721-740", "748-770", "773-791", "823-843", "855-875", "893-909"]
|
| Protein Sequence
|
>Sodium/calcium exchanger 2
MAPLALVGVTLLLAAPPCSGAATPTPSLPPPPANDSDTSTGGCQGSYRCQPGVLLPVWEP
DDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITSKEKEITITKANGETSVGT
VRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVC
IYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCV
VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLGP
GPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRL
MTGAGNVLRRHAADASRRAAPAEGAGEDEDDGASRIFFEPSLYHCLENCGSVLLSVTCQG
GEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFV
RLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGT
VDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEE
YEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLE
VIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPS
CFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLK
DSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVY
WAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFL
GLWLLYILFASLEAYCHIRGF
|
| External Links |
|---|
| GenBank ID Protein
| 57163987 |
| UniProtKB/Swiss-Prot ID
| Q9UPR5 |
| UniProtKB/Swiss-Prot Entry Name
| NAC2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_015063.2 |
| GeneCard ID
| SLC8A2 |
| GenAtlas ID
| SLC8A2 |
| HGNC ID
| HGNC:11069 |
| References |
|---|
| General References
| Not Available |