Cannabis Compound Database: Showing Protein Large neutral amino acids transporter small subunit 1 (CDBP02277)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP02277

Secondary Accession Numbers

Not Available

Name

Large neutral amino acids transporter small subunit 1

Description

Not Available

Synonyms

4F2 LC
4F2 light chain
4F2LC
CD98 light chain
Integral membrane protein E16
L-type amino acid transporter 1
Solute carrier family 7 member 5
hLAT1
y+ system cationic amino acid transporter

Gene Name

SLC7A5

Protein Type

Transporter

Biological Properties

General Function

Involved in transport

Specific Function

Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood- brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L- leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts

GO Classification

Component
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
active transmembrane transporter activity
transmembrane transporter activity
amine transmembrane transporter activity
amino acid transmembrane transporter activity
transporter activity
Process
amine transport
amino acid transport
transmembrane transport
establishment of localization
transport

Cellular Location

Cytoplasm
Multi-pass membrane protein
Apical cell membrane
cytosol

Pathways

Name	SMPDB/Pathwhiz	KEGG
Kidney Function		Not Available
Glucose Transporter Defect (SGLT2)		Not Available
Hartnup Disorder		Not Available
Iminoglycinuria		Not Available
Lysinuric Protein Intolerance		Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

16q24.3

SNPs

SLC7A5

Gene Sequence

>1524 bp
ATGGCGGGTGCGGGCCCGAAGCGGCGGGCGCTAGCGGCCCCGGTGGCCGAGGAGAAGGAA
GAGGCGCGGGAGAAGATGCTGGCCTCCAAGCGCGCGGACGGCGCGGCGCCGGCAGGCGAG
GGCGAGGGCGTGACCCTGCAGCGGAACATCACGCTACTCAACGGCGTGGCCATCATCGTG
GGCGCCATCATCGGCTCGGGCATCTTCGTGACGCCCACGGGCGTGCTTAAGGAGGCAGGC
TCGCCGGGGCTGGCGCTGGTGATGTGGGCCGCGTGCGGCGTCTTCTCCATCGTGGGCGCG
CTCTGCTACGCGGAGCTCGGCACCACCATCTCCAAATCGGGCGGCGACTACGCCTACATG
CTGGAGGTCTACGGCTCGCTGCCCGCCTTCCTCAAGCTCTGGATCGAGCTGCTCATCATC
CGGCCTTCATCGCAGTACATCGTGGCCCTGGTCTTCGCCGCCTACCTGCTCAAGCCGCTC
TTCCCCACCTGCCCGGTGCCCGAGGAGGCAGCCAAGCTCGTGGCCTGCCTCTGCGTGCTG
CTGCTCACGGCCGTGAACTGCTACAGCGTGAAGGCCGCCACCCGGGTCCAGGATGCCTTT
GCCGCCGCCAAGCTCCTGGCCCTGGCCCTGATCATCCTGCTGGGCTTCGTCCAGATCGGG
AAGGGTGATGTGTCCAATCTAGATCCCAACTTCTCATTTGAAGGCACCAAACTGGATGTG
GGGAACATTGTGCTGGCATTATACAGCGGCCTCTTTGCCTATGGAGGATGGAATTACTTG
AATTTCGTCACAGAGGAAATGATCAACCCCTACAGAAACCTGCCCCTGGCCATCATCATC
TCCCTGCCCATCGTGACGCTGGTGTACGTGCTGACCAACCTGGCCTACTTCACCACCCTG
TCCACCGAGCAGATGCTGTCGTCCGAGGCCGTGGCCGTGGACTTCGGGAACTATCACCTG
GGCGTCATGTCCTGGATCATCCCCGTCTTCGTGGGCCTGTCCTGCTTCGGCTCCGTCAAT
GGGTCCCTGTTCACATCCTCCAGGCTCTTCTTCGTGGGGTCCCGGGAAGGCCACCTGCCC
TCCATCCTCTCCATGATCCACCCACAGCTCCTCACCCCCGTGCCGTCCCTCGTGTTCACG
TGTGTGATGACGCTGCTCTACGCCTTCTCCAAGGACATCTTCTCCGTCATCAACTTCTTC
AGCTTCTTCAACTGGCTCTGCGTGGCCCTGGCCATCATCGGCATGATCTGGCTGCGCCAC
AGAAAGCCTGAGCTTGAGCGGCCCATCAAGGTGAACCTGGCCCTGCCTGTGTTCTTCATC
CTGGCCTGCCTCTTCCTGATCGCCGTCTCCTTCTGGAAGACACCCGTGGAGTGTGGCATC
GGCTTCACCATCATCCTCAGCGGGCTGCCCGTCTACTTCTTCGGGGTCTGGTGGAAAAAC
AAGCCCAAGTGGCTCCTCCAGGGCATCTTCTCCACGACCGTCCTGTGTCAGAAGCTCATG
CAGGTGGTCCCCCAGGAGACATAG

Protein Properties

Number of Residues

507

Molecular Weight

55009.6

Theoretical pI

7.79

Pfam Domain Function

AA_permease (PF00324 )

Signals

["None"]

Transmembrane Regions

["50-70", "84-104", "120-140", "146-166", "170-190", "199-219", "243-263", "274-294", "319-339", "396-416", "431-451", "458-478"]

Protein Sequence

>Large neutral amino acids transporter small subunit 1
MAGAGPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIV
GTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYM
LEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVL
LLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDV
GNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTL
STEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLP
SILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRH
RKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKN
KPKWLLQGIFSTTVLCQKLMQVVPQET

External Links

GenBank ID Protein

4519803

UniProtKB/Swiss-Prot ID

Q01650

UniProtKB/Swiss-Prot Entry Name

LAT1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AB017908

GeneCard ID