Showing Protein Sodium-coupled neutral amino acid transporter 4 (CDBP02260)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP02260
Secondary Accession Numbers Not Available
Name Sodium-coupled neutral amino acid transporter 4
Description Not Available
Synonyms
  1. Amino acid transporter A3
  2. Na(+)-coupled neutral amino acid transporter 4
  3. Solute carrier family 38 member 4
  4. System A amino acid transporter 3
  5. System N amino acid transporter 3
Gene Name SLC38A4
Protein Type Enzyme
Biological Properties
General Function Amino acid transport and metabolism
Specific Function Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5
GO Classification Not Available
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 12q13
SNPs SLC38A4
Gene Sequence 
>1644 bp
ATGGATCCCATGGAACTGAGAAATGTCAACATCGAACCAGATGATGAGAGCAGCAGTGGA
GAAAGTGCTCCAGATAGCTACATCGGGATAGGAAATTCAGAAAAGGCAGCAATGAGCAGT
CAATTTGCTAATGAAGACACTGAAAGTCAGAAATTCCTGACAAATGGATTTTTGGGGAAA
AAGAAGCTGGCAGATTATGCTGATGAACACCATCCCGGAACCACTTCCTTTGGAATGTCT
TCATTTAACCTGAGTAATGCCATCATGGGCAGTGGGATCCTGGGCTTGTCCTATGCCATG
GCCAACACAGGGATCATACTTTTTATAATCATGCTGCTTGCTGTGGCAATATTATCACTG
TATTCAGTTCACCTTTTATTAAAAACAGCCAAGGAAGGAGGGTCTTTGATTTATGAAAAA
TTAGGAGAAAAGGCATTTGGATGGCCGGGAAAAATTGGAGCTTTTGTTTCCATTACAATG
CAGAACATTGGAGCAATGTCAAGCTACCTCTTTATCATTAAATATGAACTACCTGAAGTA
ATCAGAGCATTCATGGGACTTGAAGAAAATACTGGAGAATGGTACCTCAATGGCAACTAC
CTCATCATATTTGTGTCTGTTGGAATTATTCTTCCACTTTCGCTCCTTAAAAATTTAGGT
TATCTTGGCTATACCAGTGGATTTTCTCTTACCTGCATGGTGTTTTTTGTTAGTGTGGTG
ATTTACAAGAAATTCCAAATACCCTGCCCTCTACCTGTTTTGGATCACAGTGTTGGAAAT
CTGTCATTCAACAACACGCTTCCAATGCATGTGGTAATGTTACCCAACAACTCTGAGAGT
TCTGATGTGAACTTCATGATGGATTACACCCACCGCAATCCTGCAGGGCTGGATGAGAAC
CAGGCCAAGGGCTCTCTTCATGACAGTGGAGTAGAATATGAAGCTCATAGTGATGACAAG
TGTGAACCCAAATACTTTGTATTCAACTCCCGGACGGCCTATGCAATTCCTATCCTAGTA
TTTGCTTTTGTATGCCACCCTGAGGTCCTTCCCATCTACAGTGAACTTAAAGATCGGTCC
CGGAGAAAAATGCAAACGGTGTCAAATATTTCCATCACGGGGATGCTTGTCATGTACCTG
CTTGCCGCCCTCTTTGGTTACCTAACCTTCTATGGAGAAGTTGAAGATGAATTACTTCAT
GCCTACAGCAAAGTGTATACATTAGACATCCCTCTTCTCATGGTTCGCCTGGCAGTCCTT
GTGGCAGTAACACTAACTGTGCCCATTGTCCTCTTCCCAATTCGTACATCAGTGATCACA
CTGTTATTTCCCAAACGACCCTTCAGCTGGATACGACATTTCCTGATTGCAGCTGTGCTT
ATTGCACTTAATAATGTTCTGGTCATCCTTGTGCCAACTATAAAATACATCTTCGGATTC
ATAGGGGCTTCTTCTGCCACTATGCTGATTTTTATTCTTCCAGCAGTTTTTTATCTTAAA
CTTGTCAAGAAAGAAACTTTTAGGTCACCCCAAAAGGTCGGGGCTTTAATTTTCCTTGTG
GTTGGAATATTCTTCATGATTGGAAGCATGGCACTCATTATAATTGACTGGATTTATGAT
CCTCCAAATTCCAAGCATCACTAA
Protein Properties
Number of Residues 547
Molecular Weight 60763.6
Theoretical pI 6.45
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["81-101", "105-125", "152-172", "196-216", "221-241", "333-353", "370-390", "412-432", "454-474", "477-497", "515-535"]
Protein Sequence 
>Sodium-coupled neutral amino acid transporter 4
MDPMELRNVNIEPDDESSSGESAPDSYIGIGNSEKAAMSSQFANEDTESQKFLTNGFLGK
KKLADYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSL
YSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEV
IRAFMGLEENTGEWYLNGNYLIIFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVFFVSVV
IYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPNNSESSDVNFMMDYTHRNPAGLDEN
QAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAYAIPILVFAFVCHPEVLPIYSELKDRS
RRKMQTVSNISITGMLVMYLLAALFGYLTFYGEVEDELLHAYSKVYTLDIPLLMVRLAVL
VAVTLTVPIVLFPIRTSVITLLFPKRPFSWIRHFLIAAVLIALNNVLVILVPTIKYIFGF
IGASSATMLIFILPAVFYLKLVKKETFRSPQKVGALIFLVVGIFFMIGSMALIIIDWIYD
PPNSKHH
GenBank ID Protein 18369789
UniProtKB/Swiss-Prot ID Q969I6
UniProtKB/Swiss-Prot Entry Name S38A4_HUMAN
PDB IDs Not Available
GenBank Gene ID AB055003
GeneCard ID SLC38A4
GenAtlas ID SLC38A4
HGNC ID HGNC:14679
References
General References Not Available