Showing Protein CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (CDBP02254)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP02254
Secondary Accession Numbers Not Available
Name CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
Description Not Available
Synonyms
  1. Alpha 2,3-ST 4
  2. Alpha 2,3-sialyltransferase IV
  3. Beta-galactoside alpha-2,3-sialyltransferase 4
  4. Gal-NAc6S
  5. Gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase
  6. SAT-3
  7. SIAT4-C
  8. ST-4
  9. ST3Gal IV
  10. ST3GalA.2
  11. ST3GalIV
  12. STZ
  13. Sialyltransferase 4C
Gene Name ST3GAL4
Protein Type Enzyme
Biological Properties
General Function Involved in sialyltransferase activity
Specific Function It may catalyze the formation of the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc-sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the corresponding 1,3-galactosyl derivative.
GO Classification
Biological Process
keratan sulfate biosynthetic process
O-glycan processing
post-translational protein modification
protein N-linked glycosylation via asparagine
Cellular Component
Golgi cisterna membrane
integral to Golgi membrane
extracellular region
Golgi membrane
Component
membrane part
intrinsic to membrane
intrinsic to organelle membrane
intrinsic to golgi membrane
integral to golgi membrane
cell part
Function
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
sialyltransferase activity
Molecular Function
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
monosialoganglioside sialyltransferase activity
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
protein amino acid glycosylation
Cellular Location
  1. Secreted
  2. Single-pass type II membrane protein
  3. Golgi apparatus
  4. Golgi stack membrane
Pathways
Gene Properties
Chromosome Location 11
Locus 11q24.2
SNPs ST3GAL4
Gene Sequence 
>1002 bp
ATGGTCAGCAAGTCCCGCTGGAAGCTCCTGGCCATGTTGGCTCTGGTCCTGGTCGTCATG
GTGTGGTATTCCATCTCCCGGGAAGACAGGTACATCGAGCTTTTTTATTTTCCCATCCCA
GAGAAGAAGGAGCCGTGCCTCCAGGGTGAGGCAGAGAGCAAGGCCTCTAAGCTCTTTGGC
AACTACTCCCGGGATCAGCCCATCTTCCTGCGGCTTGAGGATTATTTCTGGGTCAAGACG
CCATCTGCTTACGAGCTGCCCTATGGGACCAAGGGGAGTGAGGATCTGCTCCTCCGGGTG
CTAGCCATCACCAGCTCCTCCATCCCCAAGAACATCCAGAGCCTCAGGTGCCGCCGCTGT
GTGGTCGTGGGGAACGGGCACCGGCTGCGGAACAGCTCACTGGGAGATGCCATCAACAAG
TACGATGTGGTCATCAGATTGAACAATGCCCCAGTGGCTGGCTATGAGGGTGACGTGGGC
TCCAAGACCACCATGCGTCTCTTCTACCCTGAATCTGCCCACTTCGACCCCAAAGTAGAA
AACAACCCAGACACACTCCTCGTCCTGGTAGCTTTCAAGGCAATGGACTTCCACTGGATT
GAGACCATCCTGAGTGATAAGAAGCGGGTGCGAAAGGGTTTCTGGAAACAGCCTCCCCTC
ATCTGGGATGTCAATCCTAAACAGATTCGGATTCTCAACCCCTTCTTCATGGAGATTGCA
GCTGACAAACTGCTGAGCCTGCCAATGCAACAGCCACGGAAGATTAAGCAGAAGCCCACC
ACGGGCCTGTTGGCCATCACGCTGGCCCTCCACCTCTGTGACTTGGTGCACATTGCCGGC
TTTGGCTACCCAGACGCCTACAACAAGAAGCAGACCATTCACTACTATGAGCAGATCACG
CTCAAGTCCATGGCGGGGTCAGGCCATAATGTCTCCCAAGAGGCCCTGGCCATTAAGCGG
ATGCTGGAGATGGGAGCTATCAAGAACCTCACGTCCTTCTGA
Protein Properties
Number of Residues 333
Molecular Weight 38045.1
Theoretical pI 9.413
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
MVSKSRWKLLAMLALVLVVMVWYSISREDRYIELFYFPIPEKKEPCLQGEAESKASKLFG
NYSRDQPIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRVLAITSSSIPKNIQSLRCRRC
VVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVE
NNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIA
ADKLLSLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGFGYPDAYNKKQTIHYYEQIT
LKSMAGSGHNVSQEALAIKRMLEMGAIKNLTSF
GenBank ID Protein 14714972
UniProtKB/Swiss-Prot ID Q11206
UniProtKB/Swiss-Prot Entry Name SIA4C_HUMAN
PDB IDs Not Available
GenBank Gene ID BC010645
GeneCard ID ST3GAL4
GenAtlas ID ST3GAL4
HGNC ID HGNC:10864
References
General References Not Available