| Identification |
|---|
| HMDB Protein ID
| CDBP02242 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phosphoethanolamine/phosphocholine phosphatase |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| PHOSPHO1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.
|
| GO Classification
|
| Biological Process |
| phosphatidylethanolamine biosynthetic process |
| phosphatidylcholine biosynthetic process |
| regulation of bone mineralization |
| Cellular Component |
| cytosol |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| Molecular Function |
| pyrophosphatase activity |
| metal ion binding |
| phosphocholine phosphatase activity |
| phosphoethanolamine phosphatase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycerophospholipid metabolism | Not Available |  | | Phospholipid Biosynthesis |    | |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17q21.32 |
| SNPs
| PHOSPHO1 |
| Gene Sequence
|
>804 bp
ATGAGTGGCTGTTTTCCAGTTTCTGGCCTCCGCTGCCTATCTAGGGACGGCAGGATGGCC
GCGCAGGGCGCGCCGCGCTTCCTCCTGACCTTCGACTTCGACGAGACTATCGTGGACGAA
AACAGCGACGATTCGATCGTGCGCGCCGCGCCGGGCCAGCGGCTCCCGGAGAGCCTGCGA
GCCACCTACCGCGAGGGCTTCTACAACGAGTACATGCAGCGCGTCTTCAAGTACCTGGGC
GAGCAGGGCGTGCGGCCGCGGGACCTGAGCGCCATCTACGAAGCCATCCCTTTGTCGCCA
GGCATGAGCGACCTGCTGCAGTTTGTGGCAAAACAGGGCGCCTGCTTCGAGGTGATTCTC
ATCTCCGATGCCAACACCTTTGGCGTGGAGAGCTCGCTGCGCGCCGCCGGCCACCACAGC
CTGTTCCGCCGCATCCTCAGCAACCCGTCGGGGCCGGATGCGCGGGGACTGCTGGCTCTG
CGGCCGTTCCACACACACAGCTGCGCGCGCTGCCCCGCCAACATGTGCAAGCACAAGGTG
CTCAGCGACTACCTGCGCGAGCGGGCCCACGACGGCGTGCACTTCGAGCGCCTCTTCTAC
GTGGGCGACGGCGCCAACGACTTCTGCCCCATGGGGCTGCTGGCGGGCGGCGACGTGGCC
TTCCCGCGCCGCGGCTACCCCATGCACCGCCTCATTCAGGAGGCCCAGAAGGCCGAGCCC
AGCTCGTTCCGCGCCAGCGTGGTGCCCTGGGAAACGGCTGCAGATGTGCGCCTCCACCTG
CAACAGGTGCTGAAGTCGTGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 267 |
| Molecular Weight
| 32350.505 |
| Theoretical pI
| 7.65 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phosphoethanolamine/phosphocholine phosphatase
MSGCFPVSGLRCLSRDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLR
ATYREGFYNEYMQRVFKYLGEQGVRPRDLSAIYEAIPLSPGMSDLLQFVAKQGACFEVIL
ISDANTFGVESSLRAAGHHSLFRRILSNPSGPDARGLLALRPFHTHSCARCPANMCKHKV
LSDYLRERAHDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEP
SSFRASVVPWETAADVRLHLQQVLKSC
|
| External Links |
|---|
| GenBank ID Protein
| 20196839 |
| UniProtKB/Swiss-Prot ID
| Q8TCT1 |
| UniProtKB/Swiss-Prot Entry Name
| PHOP1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ457189 |
| GeneCard ID
| PHOSPHO1 |
| GenAtlas ID
| PHOSPHO1 |
| HGNC ID
| HGNC:16815 |
| References |
|---|
| General References
| Not Available |