| Identification |
|---|
| HMDB Protein ID
| CDBP02241 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sodium/potassium/calcium exchanger 2 |
| Description
| Not Available |
| Synonyms
|
- Na(+)/K(+)/Ca(2+)-exchange protein 2
- Retinal cone Na-Ca+K exchanger
- Solute carrier family 24 member 2
|
| Gene Name
| SLC24A2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9p22-p13 |
| SNPs
| SLC24A2 |
| Gene Sequence
|
>1986 bp
ATGGATCTGCAACAAAGCACCACCATCACTTCCCTAGAGAAATGGTGTTTGGATGAGTCA
CTGTCTGGCTGCAGAAGACATTATAGTGTCAAGAAAAAACTGAAGTTAATTCGAGTCTTA
GGCCTTTTCATGGGTCTGGTAGCCATTAGCACTGTCTCATTTTCAATCAGTGCCTTTTCT
GAGACAGATACACAGAGCACAGGAGAGGCCAGTGTTGTAAGTGGCCCTAGGGTAGCACAG
GGTTACCATCAGAGAACTCTCTTAGATTTAAATGACAAGATTCTGGATTATACTCCACAG
CCACCTCTTTCTAAGGAAGGCGAGTCTGAGAATAGTACAGATCACGCCCAAGGAGACTAC
CCGAAAGACATCTTTTCCCTTGAGGAGAGAAGAAAAGGTGCGATCATTCTGCATGTCATT
GGAATGATCTACATGTTCATAGCCTTAGCCATTGTCTGTGATGAGTTCTTTGTTCCTTCT
TTGACTGTCATCACTGAAAAACTGGGCATCTCTGATGATGTGGCTGGAGCCACCTTCATG
GCTGCAGGAGGGTCAGCCCCAGAACTTTTCACATCTCTCATAGGGGTATTTATCGCTCAC
AGCAACGTTGGCATAGGCACAATTGTAGGTTCAGCAGTATTCAACATCCTCTTTGTTATT
GGCATGTGTGCTCTGTTTTCTAGAGAAATCTTAAACCTGACATGGTGGCCGCTCTTTCGA
GATGTGTCTTTCTACATTGTTGACTTGATCATGCTGATCATATTTTTCCTGGATAATGTC
ATCATGTGGTGGGAAAGCTTGCTTCTCTTAACAGCTTATTTTTGCTATGTGGTTTTCATG
AAATTCAACGTCCAAGTAGAAAAATGGGTGAAGCAAATGATAAACCGCAATAAGGTCGTC
AAGGTGACAGCACCAGAAGCCCAAGCAAAGCCATCTGCAGCCAGGGACAAGGATGAACCG
ACTCTACCGGCTAAGCCGCGTCTCCAGCGAGGTGGAAGCTCTGCCTCCCTCCACAACAGT
CTCATGAGGAATAGCATCTTCCAACTCATGATACACACCCTTGACCCACTCGCCGAAGAA
CTTGGATCATATGGAAAACTAAAATATTATGACACAATGACTGAAGAAGGGAGGTTCAGA
GAAAAGGCTTCAATTCTCCACAAGATCGCCAAGAAGAAATGTCATGTGGATGAGAACGAG
CGGCAGAATGGGGCTGCCAACCACGTGGAAAAAATTGAGCTTCCAAACAGCACCAGCACA
GATGTTGAAATGACACCATCCAGTGATGCTTCAGAACCTGTACAAAATGGAAATCTCTCC
CACAACATTGAAGGTGCAGAAGCCCAGACCGCTGATGAGGAGGAGGACCAGCCTCTCAGC
CTTGCCTGGCCTTCTGAAACCCGCAAGCAAGTCACGTTTCTGATTGTTTTCCCCATAGTG
TTTCCTCTCTGGATTACGTTACCTGACGTTCGCAAACCTTCATCGAGGAAGTTTTTTCCC
ATCACGTTCTTTGGCTCCATTACCTGGATTGCAGTATTCTCTTACTTGATGGTCTGGTGG
GCGCACCAGGTTGGAGAGACAATTGGCATCAGTGAAGAGATTATGGGCCTGACCATCTTG
GCTGCTGGGACCTCCATCCCTGATCTTATCACCAGTGTCATAGTGGCCCGGAAGGGGTTA
GGGGACATGGCTGTGTCCAGCTCTGTTGGAAGCAACATTTTTGACATCACTGTAGGGCTC
CCACTGCCCTGGCTCCTGTACACCGTCATTCACAGATTCCAGCCAGTGGCTGTCAGCAGC
AATGGCCTTTTCTGTGCCATCGTCCTTCTCTTCATCATGCTGCTCTTCGTCATCCTCTCT
ATCGCCCTCTGCAAGTGGCGAATGAACAAAATCCTGGGCTTCATCATGTTTGGCCTCTAC
TTTGTGTTCCTGGTGGTGAGCGTTCTCCTAGAAGACAGAATTCTTACATGCCCCGTCTCC
ATCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 661 |
| Molecular Weight
| 73663.1 |
| Theoretical pI
| 5.94 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["133-153", "179-199", "205-225", "244-264", "266-286", "470-490", "498-518", "534-554", "570-590", "603-623", "631-651"]
|
| Protein Sequence
|
>Sodium/potassium/calcium exchanger 2
MDLQQSTTITSLEKWCLDESLSGCRRHYSVKKKLKLIRVLGLFMGLVAISTVSFSISAFS
ETDTQSTGEASVVSGPRVAQGYHQRTLLDLNDKILDYTPQPPLSKEGESENSTDHAQGDY
PKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFM
AAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFR
DVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEKWVKQMINRNKVV
KVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEE
LGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELPNSTST
DVEMTPSSDASEPVQNGNLSHNIEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIV
FPLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTIL
AAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSS
NGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSVLLEDRILTCPVS
I
|
| External Links |
|---|
| GenBank ID Protein
| 6650379 |
| UniProtKB/Swiss-Prot ID
| Q9UI40 |
| UniProtKB/Swiss-Prot Entry Name
| NCKX2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF097366 |
| GeneCard ID
| SLC24A2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |