| Identification |
|---|
| HMDB Protein ID
| CDBP02230 |
| Secondary Accession Numbers
| Not Available |
| Name
| Carbonic anhydrase 12 |
| Description
| Not Available |
| Synonyms
|
- CA-XII
- Carbonate dehydratase XII
- Carbonic anhydrase XII
- Tumor antigen HOM-RCC-3.1.3
|
| Gene Name
| CA12 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in carbonate dehydratase activity |
| Specific Function
| Reversible hydration of carbon dioxide.
|
| GO Classification
|
| Biological Process |
| one-carbon metabolic process |
| small molecule metabolic process |
| bicarbonate transport |
| Cellular Component |
| plasma membrane |
| integral to membrane |
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| carbon-oxygen lyase activity |
| hydro-lyase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| carbonate dehydratase activity |
| transition metal ion binding |
| zinc ion binding |
| lyase activity |
| Molecular Function |
| metal ion binding |
| zinc ion binding |
| carbonate dehydratase activity |
| Process |
| metabolic process |
| cellular metabolic process |
| one-carbon metabolic process |
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| 15q22 |
| SNPs
| CA12 |
| Gene Sequence
|
>1065 bp
ATGCCCCGGCGCAGCCTGCACGCGGCGGCCGTGCTCCTGCTGGTGATCTTAAAGGAACAG
CCTTCCAGCCCGGCCCCAGTGAACGGTTCCAAGTGGACTTATTTTGGTCCTGATGGGGAG
AATAGCTGGTCCAAGAAGTACCCGTCGTGTGGGGGCCTGCTGCAGTCCCCCATAGACCTG
CACAGTGACATCCTCCAGTATGACGCCAGCCTCACGCCCCTCGAGTTCCAAGGCTACAAT
CTGTCTGCCAACAAGCAGTTTCTCCTGACCAACAATGGCCATTCAGTGAAGCTGAACCTG
CCCTCGGACATGCACATCCAGGGCCTCCAGTCTCGCTACAGTGCCACGCAGCTGCACCTG
CACTGGGGGAACCCGAATGACCCGCACGGCTCTGAGCACACCGTCAGCGGACAGCACTTC
GCCGCCGAGCTGCACATTGTCCATTATAACTCAGACCTTTATCCTGACGCCAGCACTGCC
AGCAACAAGTCAGAAGGCCTCGCTGTCCTGGCTGTTCTCATTGAGATGGGCTCCTTCAAT
CCGTCCTATGACAAGATCTTCAGTCACCTTCAACATGTAAAGTACAAAGGCCAGGAAGCA
TTCGTCCCGGGATTCAACATTGAAGAGCTGCTTCCGGAGAGGACCGCTGAATATTACCGC
TACCGGGGGTCCCTGACCACACCCCCTTGCAACCCCACTGTGCTCTGGACAGTTTTCCGA
AACCCCGTGCAAATTTCCCAGGAGCAGCTGCTGGCTTTGGAGACAGCCCTGTACTGCACA
CACATGGACGACCCTTCCCCCAGAGAAATGATCAACAACTTCCGGCAGGTCCAGAAGTTC
GATGAGAGGCTGGTATACACCTCCTTCTCCCAAGTGCAAGTCTGTACTGCGGCAGGACTG
AGTCTGGGCATCATCCTCTCACTGGCCCTGGCTGGCATTCTTGGCATCTGTATTGTGGTG
GTGGTGTCCATTTGGCTTTTCAGAAGGAAGAGTATCAAAAAAGGTGATAACAAGGGAGTC
ATTTACAAGCCAGCCACCAAGATGGAGACTGAGGCCCACGCTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 354 |
| Molecular Weight
| 39450.615 |
| Theoretical pI
| 7.22 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Carbonic anhydrase 12
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O43570 |
| UniProtKB/Swiss-Prot Entry Name
| CAH12_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF051882 |
| GeneCard ID
| CA12 |
| GenAtlas ID
| CA12 |
| HGNC ID
| HGNC:1371 |
| References |
|---|
| General References
| Not Available |