Identification |
HMDB Protein ID
| CDBP02227 |
Secondary Accession Numbers
| Not Available |
Name
| Sodium/hydrogen exchanger 2 |
Description
| Not Available |
Synonyms
|
- NHE-2
- Na(+)/H(+) exchanger 2
- Solute carrier family 9 member 2
|
Gene Name
| SLC9A2 |
Protein Type
| Transporter |
Biological Properties |
General Function
| Involved in solute:hydrogen antiporter activity |
Specific Function
| Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption |
GO Classification
|
Component |
cell part |
membrane part |
intrinsic to membrane |
integral to membrane |
Function |
monovalent inorganic cation transmembrane transporter activity |
hydrogen ion transmembrane transporter activity |
transporter activity |
monovalent cation:hydrogen antiporter activity |
sodium:hydrogen antiporter activity |
solute:cation antiporter activity |
solute:hydrogen antiporter activity |
transmembrane transporter activity |
substrate-specific transmembrane transporter activity |
ion transmembrane transporter activity |
cation transmembrane transporter activity |
inorganic cation transmembrane transporter activity |
Process |
chemical homeostasis |
ion homeostasis |
cation homeostasis |
monovalent inorganic cation homeostasis |
regulation of ph |
sodium ion transport |
establishment of localization |
transport |
biological regulation |
transmembrane transport |
monovalent inorganic cation transport |
ion transport |
cation transport |
regulation of biological quality |
homeostatic process |
|
Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:2 |
Locus
| 2q11.2 |
SNPs
| SLC9A2 |
Gene Sequence
|
>2439 bp
ATGGAACCACTGGGCAACTGGAGGAGCCTGCGGGCGCCACTGCCTCCGATGCTGTTGCTG
CTGCTCCTGCAGGTGGCGGGGCCCGTGGGCGCCCTGGCGGAGACCTTGCTGAACGCGCCG
AGGGCCATGGGCACCAGTTCCAGCCCGCCTAGCCCTGCGAGCGTGGTGGCTCCCGGAACG
ACGCTGTTCGAGGAGAGCCGGCTGCCTGTGTTTACGCTGGATTACCCCCACGTGCAGATC
CCCTTCGAGATCACCCTTTGGATCCTGCTGGCCTCCCTGGCCAAGATTGGCTTCCATCTG
TATCACAAGTTGCCCACAATAGTGCCTGAGAGCTGCCTTCTTATAATGGTTGGACTTCTA
CTAGGTGGGATTATTTTTGGTGTTGATGAGAAGTCTCCCCCTGCAATGAAGACTGATGTA
TTTTTCTTGTACCTCCTCCCACCCATCGTGCTGGATGCCGGCTATTTCATGCCCACTCGC
CCATTCTTTGAGAACATTGGCACGATTTTCTGGTATGCTGTGGTAGGGACACTTTGGAAT
TCCATTGGCATTGGGGTGTCTTTGTTTGGTATCTGCCAGATCGAAGCATTCGGCCTCAGC
GACATCACTTTGCTCCAGAACCTGCTCTTTGGCAGCTTAATCTCAGCTGTCGATCCTGTG
GCTGTGCTTGCTGTCTTTGAGAACATTCACGTCAATGAGCAGCTCTACATCCTGGTCTTT
GGAGAGTCCCTGCTGAATGATGCAGTAACAGTGGTCCTGTACAACTTGTTCAAGTCGTTT
TGCCAGATGAAAACCATTGAGACCATTGATGTGTTTGCAGGAATCGCCAACTTCTTTGTT
GTGGGAATCGGTGGGGTGCTGATTGGCATCTTCTTGGGCTTTATAGCGGCATTTACTACT
CGATTCACCCATAATATCCGAGTGATCGAGCCACTGTTTGTTTTCCTGTACAGTTATTTG
TCCTACATCACAGCTGAAATGTTTCACCTCTCAGGCATCATGGCAATCACTGCTTGTGCA
ATGACTATGAATAAGTACGTAGAAGAAAATGTATCTCAGAAATCCTACACGACCATCAAG
TACTTCATGAAGATGCTGAGCAGTGTCAGCGAAACCTTGATCTTCATCTTCATGGGTGTG
TCTACCGTGGGCAAGAACCACGAGTGGAACTGGGCCTTCGTCTGCTTCACCCTGGCCTTC
TGCCTCATGTGGCGAGCCCTGGGTGTTTTTGTCCTGACTCAGGTCATTAATAGGTTCCGG
ACCATTCCCCTGACCTTTAAGGACCAGTTCATCATTGCCTATGGAGGACTTCGAGGTGCC
ATCTGTTTTGCGTTAGTGTTTCTCCTTCCTGCTGCTGTGTTTCCTCGGAAAAAATTGTTT
ATTACGGCTGCCATTGTTGTCATATTCTTTACTGTCTTCATTCTGGGAATAACTATTCGA
CCACTGGTGGAGTTTCTTGATGTCAAGAGGTCCAATAAGAAACAACAAGCTGTCAGTGAA
GAAATCTATTGTCGGTTGTTTGATCATGTGAAGACTGGAATTGAAGATGTTTGTGGACAT
TGGGGTCACAACTTTTGGAGAGACAAGTTTAAGAAGTTTGATGATAAATATCTGCGGAAG
CTTTTGATTCGGGAAAACCAACCAAAGTCAAGTATTGTATCTTTATATAAAAAGCTTGAA
ATAAAACATGCCATTGAGATGGCAGAGACTGGGATGATAAGTACTGTCCCTACATTTGCA
TCTCTAAATGATTGTCGTGAAGAAAAAATAAGGAAGGTCACGTCCAGTGAAACTGATGAA
ATTCGAGAACTCTTATCAAGAAATCTCTATCAAATCCGTCAGCGAACTTTATCCTACAAC
AGACACAGTCTGACAGCCGACACAAGTGAGAGACAAGCCAAGGAGATTCTGATTCGCCGG
CGACACAGTTTGCGAGAAAGCATTAGGAAGGACAGCAGCTTGAATCGAGAACACAGGGCT
TCCACTTCAACCTCCCGATATTTATCCTTACCTAAAAATACGAAGCTTCCAGAAAAGCTA
CAAAAGAGGAGGACTATTTCTATTGCAGATGGCAATAGCAGCGACTCAGACGCAGATGCC
GGGACCACCGTGCTCAATTTGCAGCCCAGAGCCAGGCGCTTCTTGCCAGAACAGTTCTCC
AAGAAATCCCCCCAGTCCTATAAAATGGAATGGAAGAATGAGGTAGATGTTGATTCTGGC
CGAGATATGCCCAGCACCCCCCCAACACCCCACAGCAGAGAAAAGGGCACCCAGACGTCA
GGCTTACTACAGCAGCCCCTTCTCTCTAAAGACCAGTCTGGCTCAGAGAGGGAAGACAGT
TTGACTGAAGGCATCCCGCCCAAGCCGCCACCACGGCTGGTCTGGAGGGCATCGGAACCT
GGAAGCCGGAAAGCCCGATTTGGGAGTGAGAAGCCTTAA
|
Protein Properties |
Number of Residues
| 812 |
Molecular Weight
| 91518.8 |
Theoretical pI
| 9.48 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
- ["107-127", "139-159", "169-189", "209-229", "237-257", "278-298", "308-328", "361-381", "392-412", "459-479"]
|
Protein Sequence
|
>Sodium/hydrogen exchanger 2
MEPLGNWRSLRAPLPPMLLLLLLQVAGPVGALAETLLNAPRAMGTSSSPPSPASVVAPGT
TLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLL
LGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWN
SIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVF
GESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTT
RFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIK
YFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFR
TIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIR
PLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRK
LLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDE
IRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRA
STSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFS
KKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDS
LTEGIPPKPPPRLVWRASEPGSRKARFGSEKP
|
External Links |
GenBank ID Protein
| 6624113 |
UniProtKB/Swiss-Prot ID
| Q9UBY0 |
UniProtKB/Swiss-Prot Entry Name
| SL9A2_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| AC007239 |
GeneCard ID
| SLC9A2 |
GenAtlas ID
| SLC9A2 |
HGNC ID
| HGNC:11072 |
References |
General References
| Not Available |