| Identification |
|---|
| HMDB Protein ID
| CDBP02224 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cytochrome b reductase 1 |
| Description
| Not Available |
| Synonyms
|
- Duodenal cytochrome b
- Ferric-chelate reductase 3
|
| Gene Name
| CYBRD1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ferric-chelate reductase activity |
| Specific Function
| Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q31.1 |
| SNPs
| CYBRD1 |
| Gene Sequence
|
>861 bp
ATGGCCATGGAGGGCTACTGGCGCTTCCTGGCGCTGCTGGGGTCGGCACTGCTCGTCGGC
TTCCTGTCGGTGATCTTCGCCCTCGTCTGGGTCCTCCACTACCGAGAGGGGCTTGGCTGG
GATGGGAGCGCACTAGAGTTTAACTGGCACCCAGTGCTCATGGTCACCGGCTTCGTCTTC
ATCCAGGGCATCGCCATCATCGTCTACAGACTGCCGTGGACCTGGAAATGCAGCAAGCTC
CTGATGAAATCCATCCATGCAGGGTTAAATGCAGTTGCTGCCATTCTTGCAATTATCTCT
GTGGTGGCCGTGTTTGAGAACCACAATGTTAACAATATAGCCAATATGTACAGTCTGCAC
AGCTGGGTTGGACTGATAGCTGTCATATGCTATTTGTTACAGCTTCTTTCAGGTTTTTCA
GTCTTTCTGCTTCCATGGGCTCCGCTTTCTCTCCGAGCATTTCTCATGCCCATACATGTT
TATTCTGGAATTGTCATCTTTGGAACAGTGATTGCAACAGCACTTATGGGATTGACAGAG
AAACTGATTTTTTCCCTGAGAGATCCTGCATACAGTACATTCCCGCCAGAAGGTGTTTTC
GTAAATACGCTTGGCCTTCTGATCCTGGTGTTCGGGGCCCTCATTTTTTGGATAGTCACC
AGACCGCAATGGAAACGTCCTAAGGAGCCAAATTCTACCATTCTTCATCCAAATGGAGGC
ACTGAACAGGGAGCAAGAGGTTCCATGCCAGCCTACTCTGGCAACAACATGGACAAATCA
GATTCAGAGTTAAACAGTGAAGTAGCAGCAAGGAAAAGAAACTTAGCTCTGGATGAGGCT
GGGCAGAGATCTACCATGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 286 |
| Molecular Weight
| 31641.0 |
| Theoretical pI
| 9.02 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["12-32", "49-69", "85-105", "123-143", "158-178", "199-219"]
|
| Protein Sequence
|
>Cytochrome b reductase 1
MAMEGYWRFLALLGSALLVGFLSVIFALVWVLHYREGLGWDGSALEFNWHPVLMVTGFVF
IQGIAIIVYRLPWTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIANMYSLH
SWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGLTE
KLIFSLRDPAYSTFPPEGVFVNTLGLLILVFGALIFWIVTRPQWKRPKEPNSTILHPNGG
TEQGARGSMPAYSGNNMDKSDSELNSEVAARKRNLALDEAGQRSTM
|
| External Links |
|---|
| GenBank ID Protein
| 62822181 |
| UniProtKB/Swiss-Prot ID
| Q53TN4 |
| UniProtKB/Swiss-Prot Entry Name
| CYBR1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AC007969 |
| GeneCard ID
| CYBRD1 |
| GenAtlas ID
| CYBRD1 |
| HGNC ID
| HGNC:20797 |
| References |
|---|
| General References
| Not Available |