Cannabis Compound Database: Showing Protein Sodium/hydrogen exchanger 8 (CDBP02223)

Identification Biological properties Gene properties Protein properties External links References XML Show 0 compounds

Identification

HMDB Protein ID

CDBP02223

Secondary Accession Numbers

Not Available

Name

Sodium/hydrogen exchanger 8

Description

Not Available

Synonyms

NHE-8
Na(+)/H(+) exchanger 8
Solute carrier family 9 member 8

Gene Name

SLC9A8

Protein Type

Transporter

Biological Properties

General Function

Involved in solute:hydrogen antiporter activity

Specific Function

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction

GO Classification

Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
solute:hydrogen antiporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
hydrogen ion transmembrane transporter activity
transporter activity
monovalent cation:hydrogen antiporter activity
sodium:hydrogen antiporter activity
solute:cation antiporter activity
Process
transmembrane transport
monovalent inorganic cation transport
ion transport
cation transport
regulation of biological quality
homeostatic process
chemical homeostasis
ion homeostasis
cation homeostasis
monovalent inorganic cation homeostasis
regulation of ph
sodium ion transport
establishment of localization
transport
biological regulation

Cellular Location

Golgi apparatus membrane
Multi-pass membrane protein

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:2

Locus

20q13.13

SNPs

SLC9A8

Gene Sequence

>1746 bp
ATGGGGGAGAAGATGGCGGAAGAGGAGAGGTTCCCCAATACAACTCATGAGGGTTTCAAT
GTCACCCTCCACACCACCCTGGTTGTCACGACGAAACTGGTGCTCCCGACCCCTGGCAAG
CCCATCCTCCCCGTGCAGACAGGGGAGCAGGCCCAGCAAGAGGAGCAGTCCAGCGGCATG
ACCATTTTCTTCAGCCTCCTTGTCCTAGCTATCTGCATCATATTGGTGCATTTACTGATC
CGATACAGATTACATTTCTTGCCAGAGAGTGTTGCTGTTGTTTCTTTAGGTATTCTCATG
GGAGCAGTTATAAAAATTATAGAGTTTAAAAAACTGGCGAATTGGAAGGAAGAAGAAATG
TTTCGTCCAAACATGTTTTTCCTCCTCCTGCTTCCCCCTATTATCTTTGAGTCTGGATAT
TCATTACACAAGGGTAACTTCTTTCAAAATATTGGTTCCATCACCCTGTTTGCTGTTTTT
GGGACGGCAATCTCCGCTTTTGTAGTAGGTGGAGGAATTTATTTTCTGGGTCAGGCTGAT
GTAATCTCTAAACTCAACATGACAGACAGTTTTGCGTTTGGCTCCCTAATATCTGCTGTC
GATCCAGTGGCCACTATTGCCATTTTCAATGCACTTCATGTGGACCCCGTGCTCAACATG
CTGGTCTTTGGAGAAAGTATTCTCAACGATGCAGTCTCCATTGTTCTGACCAACACAGCT
GAAGGTTTAACAAGAAAAAATATGTCAGATGTCAGTGGGTGGCAAACATTTTTACAAGCC
CTTGACTACTTCCTCAAAATGTTCTTTGGCTCTGCAGCGCTCGGCACTCTCACTGGCTTA
ATTTCTGCATTAGTGCTGAAGCATATTGACTTGAGGAAAACGCCTTCCTTGGAGTTTGGC
ATGATGATCATTTTTGCTTATCTGCCTTATGGGCTTGCAGAAGGAATCTCACTCTCAGGC
ATCATGGCCATCCTTTTCTCAGGCATCGTGATGTCCCACTACACGCACCATAACCTCTCC
CCAGTCACCCAGATCCTCATGCAGCAGACCCTCCGCACCGTGGCCTTCTTATGTGAAACA
TGTGTGTTTGCATTTCTTGGCCTGTCCATTTTTAGTTTTCCTCACAAGTTTGAAATTTCC
TTTGTCATCTGGTGCATAGTGCTTGTACTATTTGGCAGAGCGGTAAACATTTTCCCTCTT
TCCTACCTCCTGAATTTCTTCCGGGATCATAAAATCACACCGAAGATGATGTTCATCATG
TGGTTTAGTGGCCTGCGGGGAGCCATCCCCTATGCCCTGAGCCTACACCTGGACCTGGAG
CCCATGGAGAAGCGGCAGCTCATCGGCACCACCACCATCGTCATCGTGCTCTTCACCATC
CTGCTGCTGGGCGGCAGCACCATGCCCCTCATTCGCCTCATGGACATCGAGGACGCCAAG
GCACACCGCAGGAACAAGAAGGACGTCAACCTCAGCAAGACTGAGAAGATGGGCAACACT
GTGGAGTCGGAGCACCTGTCGGAGCTCACGGAGGAGGAGTACGAGGCCCACTACATCAGG
CGGCAGGACCTTAAGGGCTTCGTGTGGCTGGACGCCAAGTACCTGAACCCCTTCTTCACT
CGGAGGCTGACGCAGGAGGACCTGCACCACGGGCGCATCCAGATGAAAACTCTCACCAAC
AAGTGGTACGAGGAGGTACGCCAGGGCCCCTCCGGCTCCGAGGACGACGAGCAGGAGCTG
CTCTGA

Protein Properties

Number of Residues

581

Molecular Weight

65421.2

Theoretical pI

6.51

Pfam Domain Function

Na_H_Exchanger (PF00999 )

Signals

["None"]

Transmembrane Regions

["60-80", "84-104", "123-143", "156-176", "191-211", "264-284", "311-331", "354-374", "379-399", "417-437", "451-471"]

Protein Sequence

>Sodium/hydrogen exchanger 8
MGEKMAEEERFPNTTHEGFNVTLHTTLVVTTKLVLPTPGKPILPVQTGEQAQQEEQSSGM
TIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEM
FRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQAD
VISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTA
EGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFG
MMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCET
CVFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIM
WFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAK
AHRRNKKDVNLSKTEKMGNTVESEHLSELTEEEYEAHYIRRQDLKGFVWLDAKYLNPFFT
RRLTQEDLHHGRIQMKTLTNKWYEEVRQGPSGSEDDEQELL

External Links

GenBank ID Protein

41872703

UniProtKB/Swiss-Prot ID

Q9Y2E8

UniProtKB/Swiss-Prot Entry Name

SL9A8_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_015266.1

GeneCard ID