| Identification |
|---|
| HMDB Protein ID
| CDBP02221 |
| Secondary Accession Numbers
| Not Available |
| Name
| Thioredoxin-dependent peroxide reductase, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- AOP-1
- Antioxidant protein 1
- HBC189
- Peroxiredoxin III
- Peroxiredoxin-3
- Protein MER5 homolog
- Prx-III
|
| Gene Name
| PRDX3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Posttranslational modification, protein turnover, chaperones |
| Specific Function
| Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.
|
| GO Classification
|
| Biological Process |
| maternal placenta development |
| negative regulation of neuron apoptotic process |
| positive regulation of cell proliferation |
| negative regulation of apoptotic process |
| response to lipopolysaccharide |
| regulation of mitochondrial membrane potential |
| mitochondrion organization |
| hydrogen peroxide catabolic process |
| positive regulation of NF-kappaB transcription factor activity |
| negative regulation of kinase activity |
| myeloid cell differentiation |
| Cellular Component |
| mitochondrion |
| early endosome |
| Function |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| oxidoreductase activity |
| peroxiredoxin activity |
| catalytic activity |
| antioxidant activity |
| Molecular Function |
| alkyl hydroperoxide reductase activity |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| peroxiredoxin activity |
| peroxidase activity |
| Process |
| cellular process |
| cellular homeostasis |
| cell redox homeostasis |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10q25-q26 |
| SNPs
| PRDX3 |
| Gene Sequence
|
>771 bp
ATGGCGGCTGCTGTAGGACGGTTGCTCCGAGCGTCGGTTGCCCGACATGTGAGTGCCATT
CCTTGGGGCATTTCTGCCACTGCAGCCCTCAGGCCTGCTGCATGTGGAAGAACGAGCTTG
ACAAATTTATTGTGTTCTGGTTCCAGTCAAGCAAAATTATTCAGCACCAGTTCCTCATGC
CATGCACCTGCTGTCACCCAGCATGCACCCTATTTTAAGGGTACAGCCGTTGTCAATGGA
GAGTTCAAAGACCTAAGCCTTGATGACTTTAAGGGGAAATATTTGGTGCTTTTCTTCTAT
CCTTTGGATTTCACCTTTGTGTGTCCTACAGAAATTGTTGCTTTTAGTGACAAAGCTAAC
GAATTTCACGATGTGAACTGTGAAGTTGTCGCAGTCTCAGTGGATTCCCACTTTAGCCAT
CTTGCCTGGATAAATACACCAAGAAAGAATGGTGGTTTGGGCCACATGAACATCGCACTC
TTGTCAGACTTAACTAAGCAGATTTCCCGAGACTACGGTGTGCTGTTAGAAGGTTCTGGT
CTTGCACTAAGAGGTCTCTTCATAATTGACCCCAATGGAGTCATCAAGCATTTGAGCGTC
AACGATCTCCCAGTGGGCCGAAGCGTGGAAGAAACCCTCCGCTTGGTGAAGGCGTTCCAG
TATGTAGAAACACATGGAGAAGTCTGCCCAGCGAACTGGACACCGGATTCTCCTACGATC
AAGCCAAGTCCAGCTGCTTCCAAAGAGTACTTTCAGAAGGTAAATCAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 256 |
| Molecular Weight
| 27692.375 |
| Theoretical pI
| 7.783 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Thioredoxin-dependent peroxide reductase, mitochondrial
MAAAVGRLLRASVARHVSAIPWGISATAALRPAACGRTSLTNLLCSGSSQAKLFSTSSSC
HAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKAN
EFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGSG
LALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQYVETHGEVCPANWTPDSPTI
KPSPAASKEYFQKVNQ
|
| External Links |
|---|
| GenBank ID Protein
| 189053735 |
| UniProtKB/Swiss-Prot ID
| P30048 |
| UniProtKB/Swiss-Prot Entry Name
| PRDX3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK313169 |
| GeneCard ID
| PRDX3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:9354 |
| References |
|---|
| General References
| Not Available |