Showing Protein Sodium/hydrogen exchanger 5 (CDBP02208)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP02208
Secondary Accession Numbers Not Available
Name Sodium/hydrogen exchanger 5
Description Not Available
Synonyms
  1. NHE-5
  2. Na(+)/H(+) exchanger 5
  3. Solute carrier family 9 member 5
Gene Name SLC9A5
Protein Type Transporter
Biological Properties
General Function Inorganic ion transport and metabolism
Specific Function Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
inorganic cation transmembrane transporter activity
monovalent inorganic cation transmembrane transporter activity
hydrogen ion transmembrane transporter activity
transporter activity
monovalent cation:hydrogen antiporter activity
sodium:hydrogen antiporter activity
solute:cation antiporter activity
solute:hydrogen antiporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
Process
homeostatic process
chemical homeostasis
ion homeostasis
cation homeostasis
monovalent inorganic cation homeostasis
regulation of ph
sodium ion transport
establishment of localization
transport
biological regulation
transmembrane transport
monovalent inorganic cation transport
ion transport
cation transport
regulation of biological quality
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 16q22.1
SNPs SLC9A5
Gene Sequence 
>2691 bp
ATGCTGCGCGCCGCCCTGTCCCTGCTCGCGCTGCCCCTGGCGGGGGCGGCCGAAGAGCCC
ACCCAGAAGCCAGAGTCCCCGGGCGAGCCTCCCCCAGGCTTAGAGCTCTTCCGCTGGCAG
TGGCACGAGGTGGAGGCGCCCTACCTGGTGGCCCTGTGGATCCTGGTGGCCAGTCTGGCC
AAAATCGTGTTTCACCTGTCTCGGAAAGTAACATCTCTGGTCCCTGAGAGCTGCCTGCTG
ATTTTGCTGGGCCTGGTGCTAGGGGGAATTGTTTTGGCTGTGGCCAAGAAAGCTGAGTAC
CAGCTGGAGCCAGGCACCTTCTTCCTCTTCCTGCTGCCTCCTATTGTGTTGGACTCAGGC
TATTTCATGCCTAGCAGGCTGTTCTTTGACAACTTGGGTGCCATCCTCACCTATGCCGTG
GTAGGCACACTCTGGAATGCCTTCACAACAGGCGCTGCCCTCTGGGGCTTGCAGCAGGCT
GGACTTGTAGCCCCTAGGGTGCAGGCTGGCTTACTGGACTTCCTGCTGTTTGGGAGCCTC
ATCTCGGCGGTGGACCCCGTGGCCGTGCTAGCTGTCTTTGAGGAGGTGCACGTCAATGAG
ACTCTCTTTATCATCGTCTTTGGCGAGTCCCTGCTCAACGATGCTGTCACCGTGGTGCTG
TACAAGGTCTGCAACTCCTTTGTGGAGATGGGCTCTGCCAATGTGCAGGCCACTGACTAC
CTGAAGGGAGTCGCCTCCCTGTTTGTGGTCAGTCTGGGCGGGGCAGCCGTGGGCTTAGTC
TTTGCCTTCCTCCTGGCCCTGACCACACGCTTCACCAAGCGGGTCCGCATCATCGAGCCG
CTGCTGGTCTTCCTCCTCGCCTACGCAGCCTACCTCACTGCTGAAATGGCCTCGCTCTCC
GCCATTCTTGCGGTGACCATGTGTGGCCTGGGCTGTAAGAAGTACGTGGAGGCCAACATC
TCCCATAAGTCACGCACAACTGTCAAATATACAATGAAGACTCTAGCCAGCTGTGCTGAG
ACCGTGATCTTCATGCTGCTTGGCATCTCAGCCGTGGACTCTTCTAAGTGGGCCTGGGAT
TCTGGGCTGGTGCTGGGCACCCTCATCTTCATCCTGTTCTTCCGAGCCCTCGGCGTAGTC
CTGCAGACCTGGGTGCTGAATCAGTTCCGGCTAGTCCCTCTGGACAAGATTGACCAAGTG
GTGATGTCCTATGGGGGCCTGCGGGGGGCTGTGGCCTTTGCTCTCGTCATCCTACTGGAT
AGGACCAAGGTCCCTGCCAAGGACTACTTTGTAGCCACCACTATTGTAGTGGTCTTCTTC
ACAGTCATCGTGCAGGGCTTGACCATCAAGCCACTGGTCAAATGGCTGAAGGTGAAGAGG
AGTGAGCATCACAAACCCACCCTGAACCAGGAGCTGCATGAACACACTTTTGACCACATT
CTGGCTGCAGTGGAGGACGTTGTGGGGCACCATGGCTACCACTACTGGAGGGACAGGTGG
GAGCAGTTTGACAAGAAATACCTGAGTCAGCTGCTGATGCGACGATCAGCCTACCGCATC
CGGGACCAGATCTGGGATGTGTACTACAGGCTTAACATCCGGGATGCCATCAGCTTTGTG
GACCAGGGAGGCCACGTCTTGTCTTCCACAGGTCTCACTCTGCCTTCTATGCCCAGCCGC
AATTCTGTGGCAGAAACTTCTGTCACCAACCTGCTGAGGGAGAGTGGCAGTGGAGCGTGT
CTGGATCTGCAGGTGATTGACACAGTACGCAGCGGCCGGGATCGTGAGGATGCTGTGATG
CATCATCTGCTCTGCGGAGGCCTCTACAAGCCGCGCCGTAGGTACAAAGCCAGCTGCAGT
CGCCACTTCATCTCAGAGGATGCGCAGGAGCGGCAGGACAAGGAGGTCTTCCAGCAGAAC
ATGAAGCGGCGGCTGGAGTCCTTTAAGTCCACCAAGCACAACATCTGCTTCACCAAGAGC
AAGCCACGACCCCGCAAGACTGGCCGCAGGAAGAAGGATGGTGTGGCGAATGCTGAGGCT
ACAAATGGGAAACATCGAGGCCTGGGCTTTCAGGACACAGCTGCTGTGATATTAACCGTG
GAGTCTGAGGAGGAGGAGGAGGAGAGCGACAGTTCAGAGACAGAGAAGGAGGACGATGAG
GGGATCATCTTTGTGGCTCGTGCCACCAGTGAGGTTCTCCAAGAGGGCAAGGTCTCAGGA
AGCCTTGAGGTGTGCCCAAGCCCACGAATCATTCCCCCCTCCCCAACCTGTGCAGAAAAG
GAGCTCCCCTGGAAGAGTGGGCAGGGGGACCTGGCAGTGTACGTGTCCTCGGAAACCACC
AAGATTGTGCCTGTGGACATGCAGACGGGTTGGAACCAGAGCATCTCATCCCTGGAGAGC
CTAGCGTCCCCTCCCTGTAACCAGGCCCCAATTCTGACCTGCCTGCCTCCCCATCCACGG
GGCACTGAAGAGCCCCAGGTCCCTCTCCACCTACCTTCTGATCCACGCTCTAGCTTCGCC
TTCCCACCGAGCCTGGCCAAGGCTGGCCGCTCTCGCAGTGAGAGCAGCGCTGACCTCCCC
CAGCAGCAGGAGCTGCAGCCCCTCATGGGCCACAAGGACCACACCCATCTCAGCCCAGGC
ACCGCTACCTCCCACTGGTGCATCCAGTTCAACAGAGGCAGCCGGCTGTAG
Protein Properties
Number of Residues 896
Molecular Weight 99010.5
Theoretical pI 7.61
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["46-66", "74-94", "104-124", "135-155", "174-194", "201-221", "247-267", "277-297", "332-352", "361-381", "399-419", "429-449"]
Protein Sequence 
>Sodium/hydrogen exchanger 5
MLRAALSLLALPLAGAAEEPTQKPESPGEPPPGLELFRWQWHEVEAPYLVALWILVASLA
KIVFHLSRKVTSLVPESCLLILLGLVLGGIVLAVAKKAEYQLEPGTFFLFLLPPIVLDSG
YFMPSRLFFDNLGAILTYAVVGTLWNAFTTGAALWGLQQAGLVAPRVQAGLLDFLLFGSL
ISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVVLYKVCNSFVEMGSANVQATDY
LKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVRIIEPLLVFLLAYAAYLTAEMASLS
AILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGISAVDSSKWAWD
SGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLD
RTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVKRSEHHKPTLNQELHEHTFDHI
LAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLMRRSAYRIRDQIWDVYYRLNIRDAISFV
DQGGHVLSSTGLTLPSMPSRNSVAETSVTNLLRESGSGACLDLQVIDTVRSGRDREDAVM
HHLLCGGLYKPRRRYKASCSRHFISEDAQERQDKEVFQQNMKRRLESFKSTKHNICFTKS
KPRPRKTGRRKKDGVANAEATNGKHRGLGFQDTAAVILTVESEEEEEESDSSETEKEDDE
GIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKELPWKSGQGDLAVYVSSETT
KIVPVDMQTGWNQSISSLESLASPPCNQAPILTCLPPHPRGTEEPQVPLHLPSDPRSSFA
FPPSLAKAGRSRSESSADLPQQQELQPLMGHKDHTHLSPGTATSHWCIQFNRGSRL
GenBank ID Protein 4071359
UniProtKB/Swiss-Prot ID Q14940
UniProtKB/Swiss-Prot Entry Name SL9A5_HUMAN
PDB IDs Not Available
GenBank Gene ID AF111173
GeneCard ID SLC9A5
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available