| Identification |
|---|
| HMDB Protein ID
| CDBP02191 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phosphopantothenate--cysteine ligase |
| Description
| Not Available |
| Synonyms
|
- PPC synthetase
- Phosphopantothenoylcysteine synthetase
|
| Gene Name
| PPCS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine.
|
| GO Classification
|
| Biological Process |
| coenzyme biosynthetic process |
| pantothenate metabolic process |
| coenzyme A biosynthetic process |
| Cellular Component |
| cytosol |
| Molecular Function |
| phosphopantothenate--cysteine ligase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Pantothenate and CoA Biosynthesis |    |  | | coenzyme A biosynthesis | Not Available | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p34.2 |
| SNPs
| PPCS |
| Gene Sequence
|
>417 bp
ATGTTTTACCTGGCTGCGGCTGTGTCAGATTTCTATGTTCCTGTCTCTGAAATGCCTGAA
CACAAGATCCAGTCATCTGGGGGCCCACTGCAGATAACAATGAAGATGGTGCCAAAACTG
CTTTCTCCTTTGGTTAAAGATTGGGCTCCCAAAGCATTTATAATTTCCTTTAAGTTGGAG
ACTGACCCCGCCATTGTAATTAATCGAGCTCGGAAGGCTTTGGAAATTTATCAGCATCAA
GTGGTGGTGGCTAATATCCTTGAGTCACGACAGTCCTTTGTGTTTATTGTAACCAAAGAC
TCGGAAACCAAGTTATTGCTATCAGAGGAAGAAATAGAAAAAGGCGTAGAGATAGAAGAG
AAGATAGTGGATAATCTTCAGTCTCGACACACAGCTTTTATAGGTGACAGAAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 138 |
| Molecular Weight
| 15645.035 |
| Theoretical pI
| 5.889 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phosphopantothenoylcysteine synthetase
MFYLAAAVSDFYVPVSEMPEHKIQSSGGPLQITMKMVPKLLSPLVKDWAPKAFIISFKLE
TDPAIVINRARKALEIYQHQVVVANILESRQSFVFIVTKDSETKLLLSEEEIEKGVEIEE
KIVDNLQSRHTAFIGDRN
|
| External Links |
|---|
| GenBank ID Protein
| 55665120 |
| UniProtKB/Swiss-Prot ID
| Q9HAB8 |
| UniProtKB/Swiss-Prot Entry Name
| Q5VVM0_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AL445669 |
| GeneCard ID
| PPCS |
| GenAtlas ID
| PPCS |
| HGNC ID
| HGNC:25686 |
| References |
|---|
| General References
| Not Available |