Cannabis Compound Database: Showing Protein 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (CDBP02188)

Identification Biological properties Gene properties Protein properties External links References XML Show 8 compounds

Identification

HMDB Protein ID

CDBP02188

Secondary Accession Numbers

Not Available

Name

1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

Description

Not Available

Synonyms

1-AGP acyltransferase 5
1-AGPAT 5
1-acylglycerol-3-phosphate O-acyltransferase 5
LPAAT-epsilon
Lysophosphatidic acid acyltransferase epsilon

Gene Name

AGPAT5

Protein Type

Enzyme

Biological Properties

General Function

Involved in acyltransferase activity

Specific Function

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable.

GO Classification

Biological Process
small molecule metabolic process
CDP-diacylglycerol biosynthetic process
phosphatidic acid biosynthetic process
triglyceride biosynthetic process
Cellular Component
endoplasmic reticulum membrane
mitochondrial outer membrane
integral to membrane
Function
catalytic activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
acyltransferase activity
Molecular Function
1-acylglycerol-3-phosphate O-acyltransferase activity
Process
metabolic process

Cellular Location

Membrane
Multi-pass membrane protein (Potential)

Pathways

Name	SMPDB/Pathwhiz	KEGG
CDP-diacylglycerol biosynthesis	Not Available	Not Available
Cardiolipin Biosynthesis CL(i-13:0/i-16:0/i-13:0/i-17:0)		Not Available
Cardiolipin Biosynthesis CL(i-14:0/i-15:0/i-20:0/i-18:0)		Not Available
Cardiolipin Biosynthesis CL(a-13:0/i-12:0/a-15:0/i-12:0)		Not Available
Cardiolipin Biosynthesis		Not Available

Gene Properties

Chromosome Location

Locus

8p23.1

SNPs

AGPAT5

Gene Sequence

>1095 bp
ATGCTGCTGTCCCTGGTGCTCCACACGTACTCCATGCGCTACCTGCTGCCCAGCGTCGTG
CTCCTGGGCACGGCGCCCACCTACGTGTTGGCCTGGGGGGTCTGGCGGCTGCTCTCCGCC
TTCCTGCCCGCCCGCTTCTACCAAGCGCTGGACGACCGGCTCTACTGCGTCTACCAGAGC
ATGGTGCTCTTCTTCTTCGAGAATTACACCGGGGTCCAGATATTGCTATATGGAGATTTG
CCAAAAAATAAAGAAAATATAATATATTTAGCAAATCATCAAAGCACAGTTGACTGGATT
GTTGCTGACATCTTGGCCATCAGGCAGAATGCGCTAGGACATGTGCGCTACGTGCTGAAA
GAAGGGTTAAAATGGCTGCCATTGTATGGGTGTTACTTTGCTCAGCATGGAGGAATCTAT
GTAAAGCGCAGTGCCAAATTTAACGAGAAAGAGATGCGAAACAAGTTGCAGAGCTACGTG
GACGCAGGAACTCCAATGTATCTTGTGATTTTTCCAGAAGGTACAAGGTATAATCCAGAG
CAAACAAAAGTCCTTTCAGCTAGTCAGGCATTTGCTGCCCAACGTGGCCTTGCAGTATTA
AAACATGTGCTAACACCACGAATAAAGGCAACTCACGTTGCTTTTGATTGCATGAAGAAT
TATTTAGATGCAATTTATGATGTTACGGTGGTTTATGAAGGGAAAGACGATGGAGGGCAG
CGAAGAGAGTCACCGACCATGACGGAATTTCTCTGCAAAGAATGTCCAAAAATTCATATT
CACATTGATCGTATCGACAAAAAAGATGTCCCAGAAGAACAAGAACATATGAGAAGATGG
CTGCATGAACGTTTCGAAATCAAAGATAAGATGCTTATAGAATTTTATGAGTCACCAGAT
CCAGAAAGAAGAAAAAGATTTCCTGGGAAAAGTGTTAATTCCAAATTAAGTATCAAGAAG
ACTTTACCATCAATGTTGATCTTAAGTGGTTTGACTGCAGGCATGCTTATGACCGATGCT
GGAAGGAAGCTGTATGTGAACACCTGGATATATGGAACCCTACTTGGCTGCCTGTGGGTT
ACTATTAAAGCATAG

Protein Properties

Number of Residues

364

Molecular Weight

42071.835

Theoretical pI

9.093

Pfam Domain Function

Acyltransferase (PF01553 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
MLLSLVLHTYSMRYLLPSVVLLGTAPTYVLAWGVWRLLSAFLPARFYQALDDRLYCVYQS
MVLFFFENYTGVQILLYGDLPKNKENIIYLANHQSTVDWIVADILAIRQNALGHVRYVLK
EGLKWLPLYGCYFAQHGGIYVKRSAKFNEKEMRNKLQSYVDAGTPMYLVIFPEGTRYNPE
QTKVLSASQAFAAQRGLAVLKHVLTPRIKATHVAFDCMKNYLDAIYDVTVVYEGKDDGGQ
RRESPTMTEFLCKECPKIHIHIDRIDKKDVPEEQEHMRRWLHERFEIKDKMLIEFYESPD
PERRKRFPGKSVNSKLSIKKTLPSMLILSGLTAGMLMTDAGRKLYVNTWIYGTLLGCLWV
TIKA

External Links

GenBank ID Protein

14161585

UniProtKB/Swiss-Prot ID

Q9NUQ2

UniProtKB/Swiss-Prot Entry Name

PLCE_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF375789

GeneCard ID