| Identification |
|---|
| HMDB Protein ID
| CDBP02180 |
| Secondary Accession Numbers
| Not Available |
| Name
| Signal peptidase complex subunit 1 |
| Description
| Not Available |
| Synonyms
|
- Microsomal signal peptidase 12 kDa subunit
- SPase 12 kDa subunit
|
| Gene Name
| SPCS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in peptidase activity |
| Specific Function
| Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum |
| GO Classification
|
| Component |
| integral to membrane |
| signal peptidase complex |
| cell part |
| membrane part |
| macromolecular complex |
| intrinsic to membrane |
| protein complex |
| Function |
| catalytic activity |
| hydrolase activity |
| peptidase activity |
| Process |
| metabolic process |
| cellular metabolic process |
| signal peptide processing |
| peptide metabolic process |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
- Microsome membrane
- Multi- pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Biotin Metabolism |    |  | | Biotinidase Deficiency |    | Not Available | | Multiple carboxylase deficiency, neonatal or early onset form |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3p21.1 |
| SNPs
| SPCS1 |
| Gene Sequence
|
>309 bp
ATGCTGGAGCATCTGAGCTCGCTGCCCACGCAGATGGATTACAAGGGCCAGAAGCTAGCT
GAACAGATGTTTCAGGGAATTATTCTTTTTTCTGCAATAGTTGGATTTATCTACGGGTAC
GTGGCTGAACAGTTCGGGTGGACTGTCTATATAGTTATGGCCGGATTTGCTTTTTCATGT
TTGCTGACACTTCCTCCATGGCCCATCTATCGCCGGCATCCTCTCAAGTGGTTACCTGTT
CAAGAATCAAGCACAGACGACAAGAAACCAGGGGAAAGAAAAATTAAGAGGCATGCTAAA
AATAATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 102 |
| Molecular Weight
| 11804.7 |
| Theoretical pI
| 9.73 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Signal peptidase complex subunit 1
MLEHLSSLPTQMDYKGQKLAEQMFQGIILFSAIVGFIYGYVAEQFGWTVYIVMAGFAFSC
LLTLPPWPIYRRHPLKWLPVQESSTDDKKPGERKIKRHAKNN
|
| External Links |
|---|
| GenBank ID Protein
| 193786537 |
| UniProtKB/Swiss-Prot ID
| Q9Y6A9 |
| UniProtKB/Swiss-Prot Entry Name
| SPCS1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK027426 |
| GeneCard ID
| SPCS1 |
| GenAtlas ID
| SPCS1 |
| HGNC ID
| HGNC:23401 |
| References |
|---|
| General References
| Not Available |