| Identification |
|---|
| HMDB Protein ID
| CDBP02165 |
| Secondary Accession Numbers
| Not Available |
| Name
| Lymphotoxin-beta |
| Description
| Not Available |
| Synonyms
|
- LT-beta
- TNF-C
- Tumor necrosis factor C
- Tumor necrosis factor ligand superfamily member 3
|
| Gene Name
| LTB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in tumor necrosis factor receptor binding |
| Specific Function
| Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| tumor necrosis factor receptor superfamily binding |
| tumor necrosis factor receptor binding |
| protein binding |
| receptor binding |
| binding |
| cytokine receptor binding |
| Process |
| immune system process |
| immune response |
|
| Cellular Location
|
- Membrane
- Single-pass type II membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6p21.3 |
| SNPs
| LTB |
| Gene Sequence
|
>735 bp
ATGGGGGCACTGGGGCTGGAGGGCAGGGGTGGGAGGCTCCAGGGGAGGGGTTCCCTCCTG
CTAGCTGTGGCAGGAGCCACTTCTCTGGTGACCTTGTTGCTGGCGGTGCCTATCACTGTC
CTGGCTGTGCTGGCCTTAGTGCCCCAGGATCAGGGAGGACTGGTAACGGAGACGGCCGAC
CCCGGGGCACAGGCCCAGCAAGGACTGGGGTTTCAGAAGCTGCCAGAGGAGGAGCCAGAA
ACAGATCTCAGCCCCGGGCTCCCAGCTGCCCACCTCATAGGCGCTCCGCTGAAGGGGCAG
GGGCTAGGCTGGGAGACGACGAAGGAACAGGCGTTTCTGACGAGCGGGACGCAGTTCTCG
GACGCCGAGGGGCTGGCGCTCCCGCAGGACGGCCTCTATTACCTCTACTGTCTCGTCGGC
TACCGGGGCCGGGCGCCCCCTGGCGGCGGGGACCCCCAGGGCCGCTCGGTCACGCTGCGC
AGCTCTCTGTACCGGGCGGGGGGCGCCTACGGGCCGGGCACTCCCGAGCTGCTGCTCGAG
GGCGCCGAGACGGTGACTCCAGTGCTGGACCCGGCCAGGAGACAAGGGTACGGGCCTCTC
TGGTACACGAGCGTGGGGTTCGGCGGCCTGGTGCAGCTCCGGAGGGGCGAGAGGGTGTAC
GTCAACATCAGTCACCCCGATATGGTGGACTTCGCGAGAGGGAAGACCTTCTTTGGGGCC
GTGATGGTGGGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 244 |
| Molecular Weight
| 25389.8 |
| Theoretical pI
| 5.02 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Lymphotoxin-beta
MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD
PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS
DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE
GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA
VMVG
|
| External Links |
|---|
| GenBank ID Protein
| 4337113 |
| UniProtKB/Swiss-Prot ID
| Q06643 |
| UniProtKB/Swiss-Prot Entry Name
| TNFC_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF129756 |
| GeneCard ID
| LTB |
| GenAtlas ID
| LTB |
| HGNC ID
| HGNC:6711 |
| References |
|---|
| General References
| Not Available |