| Identification |
|---|
| HMDB Protein ID
| CDBP02164 |
| Secondary Accession Numbers
| Not Available |
| Name
| P2Y purinoceptor 1 |
| Description
| Not Available |
| Synonyms
|
- ATP receptor
- P2Y1
- Purinergic receptor
|
| Gene Name
| P2RY1 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in activation of phospholipase C activity by G |
| Specific Function
| Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation |
| GO Classification
|
| Component |
| integral to membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| Function |
| nucleotide receptor activity, g-protein coupled |
| purinergic nucleotide receptor activity, g-protein coupled |
| receptor activity |
| transmembrane receptor activity |
| molecular transducer activity |
| signal transducer activity |
| g-protein coupled receptor activity |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q25.2 |
| SNPs
| P2RY1 |
| Gene Sequence
|
>1122 bp
ATGACCGAGGTGCTGTGGCCGGCTGTCCCCAACGGGACGGACGCTGCCTTCCTGGCCGGT
CCGGGTTCGTCCTGGGGGAACAGCACGGTCGCCTCCACTGCCGCCGTCTCCTCGTCGTTC
AAATGCGCCTTGACCAAGACGGGCTTCCAGTTTTACTACCTGCCGGCTGTCTACATCTTG
GTATTCATCATCGGCTTCCTGGGCAACAGCGTGGCCATCTGGATGTTCGTCTTCCACATG
AAGCCCTGGAGCGGCATCTCCGTGTACATGTTCAATTTGGCTCTGGCCGACTTCTTGTAC
GTGCTGACTCTGCCAGCCCTGATCTTCTACTACTTCAATAAAACAGACTGGATCTTCGGG
GATGCCATGTGTAAACTGCAGAGGTTCATCTTTCATGTGAACCTCTATGGCAGCATCTTG
TTTCTGACATGCATCAGTGCCCACCGGTACAGCGGTGTGGTGTACCCCCTCAAGTCCCTG
GGCCGGCTCAAAAAGAAGAATGCGATCTGTATCAGCGTGCTGGTGTGGCTCATTGTGGTG
GTGGCGATCTCCCCCATCCTCTTCTACTCAGGTACCGGGGTCCGCAAAAACAAAACCATC
ACCTGTTACGACACCACCTCAGACGAGTACCTGCGAAGTTATTTCATCTACAGCATGTGC
ACGACCGTGGCCATGTTCTGTGTCCCCTTGGTGCTGATTCTGGGCTGTTACGGATTAATT
GTGAGAGCTTTGATTTACAAAGATCTGGACAACTCTCCTCTGAGGAGAAAATCGATTTAC
CTGGTAATCATTGTACTGACTGTTTTTGCTGTGTCTTACATCCCTTTCCATGTGATGAAA
ACGATGAACTTGAGGGCCCGGCTTGATTTTCAGACCCCAGCAATGTGTGCTTTCAATGAC
AGGGTTTATGCCACGTATCAGGTGACAAGAGGTCTAGCAAGTCTCAACAGTTGTGTGGAC
CCCATTCTCTATTTCTTGGCGGGAGATACTTTCAGAAGGAGACTCTCCCGAGCCACAAGG
AAAGCTTCTAGAAGAAGTGAGGCAAATTTGCAATCCAAGAGTGAAGACATGACCCTCAAT
ATTTTACCTGAGTTCAAGCAGAATGGAGATACAAGCCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 373 |
| Molecular Weight
| 42071.1 |
| Theoretical pI
| 9.64 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["53-74", "88-109", "127-147", "167-188", "219-238", "266-285", "304-328"]
|
| Protein Sequence
|
>P2Y purinoceptor 1
MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYIL
VFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFG
DAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVV
VAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLI
VRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFND
RVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLN
ILPEFKQNGDTSL
|
| External Links |
|---|
| GenBank ID Protein
| 4505557 |
| UniProtKB/Swiss-Prot ID
| P47900 |
| UniProtKB/Swiss-Prot Entry Name
| P2RY1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_002563.2 |
| GeneCard ID
| P2RY1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |