| Identification |
|---|
| HMDB Protein ID
| CDBP02162 |
| Secondary Accession Numbers
| Not Available |
| Name
| 7,8-dihydro-8-oxoguanine triphosphatase |
| Description
| Not Available |
| Synonyms
|
- 8-oxo-dGTPase
- Nucleoside diphosphate-linked moiety X motif 1
- Nudix motif 1
- 2-hydroxy-dATP diphosphatase
|
| Gene Name
| NUDT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| Specific Function
| Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.
|
| GO Classification
|
| Biological Process |
| ATP catabolic process |
| dGTP catabolic process |
| DNA protection |
| DNA repair |
| response to oxidative stress |
| Cellular Component |
| mitochondrial matrix |
| nucleus |
| Function |
| catalytic activity |
| hydrolase activity |
| 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| nucleoside-triphosphate diphosphatase activity |
| hydrolase activity, acting on acid anhydrides |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| pyrophosphatase activity |
| Molecular Function |
| metal ion binding |
| 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity |
| 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| ATP diphosphatase activity |
| GTPase activity |
| snoRNA binding |
| Process |
| dna metabolic process |
| dna repair |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7p22 |
| SNPs
| NUDT1 |
| Gene Sequence
|
>594 bp
ATGTACTGGAGCAATCAGATCACACGGCGGCTTGGAGAGCGAGTGCAAGGTTTTATGAGT
GGAATTAGCCCTCAGCAGATGGGGGAGCCAGAAGGCAGTTGGAGTGGGAAGAACCCAGGG
ACCATGGGCGCCTCCAGGCTCTATACCCTGGTGCTGGTCCTGCAGCCTCAGCGAGTTCTC
CTGGGCATGAAAAAGCGAGGCTTCGGGGCCGGCCGGTGGAATGGCTTTGGGGGCAAAGTG
CAAGAAGGAGAGACCATCGAGGATGGGGCTAGGAGGGAGCTGCAGGAGGAGAGCGGTCTG
ACAGTGGACGCCCTGCACAAGGTGGGCCAGATCGTGTTTGAGTTCGTGGGCGAGCCTGAG
CTCATGGACATGCATGTCTTCTGCACAGACAGCATCCAGGGGACCCCCGTGGAGAGCGAC
GAAATGCGCCCATGCTGGTTCCAGCTGGATCAGATCCCCTTCAAGGACATGTGGCCCGAC
GACAGCTACTGGTTTCCACTCCTGCTTCAGAAGAAGAAATTCCACGGGTACTTCAAGTTC
CAGGGTCAGGACACCATCCTGGACTACACACTCCGCGAGGTGGACACGGTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 197 |
| Molecular Weight
| 17951.435 |
| Theoretical pI
| 5.086 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>7,8-dihydro-8-oxoguanine triphosphatase
MYWSNQITRRLGERVQGFMSGISPQQMGEPEGSWSGKNPGTMGASRLYTLVLVLQPQRVL
LGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPE
LMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQKKKFHGYFKF
QGQDTILDYTLREVDTV
|
| External Links |
|---|
| GenBank ID Protein
| 5821385 |
| UniProtKB/Swiss-Prot ID
| P36639 |
| UniProtKB/Swiss-Prot Entry Name
| 8ODP_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB025240 |
| GeneCard ID
| NUDT1 |
| GenAtlas ID
| NUDT1 |
| HGNC ID
| HGNC:8048 |
| References |
|---|
| General References
| Not Available |