| Identification |
|---|
| HMDB Protein ID
| CDBP02139 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sodium- and chloride-dependent taurine transporter |
| Description
| Not Available |
| Synonyms
|
- Solute carrier family 6 member 6
|
| Gene Name
| SLC6A6 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in neurotransmitter:sodium symporter activity |
| Specific Function
| Required for the uptake of taurine. Transports both taurine and beta-alanine which requires sodium ions. Chloride ions are necessary for optimal uptake.
|
| GO Classification
|
| Biological Process |
| amino acid transport |
| cellular amino acid metabolic process |
| taurine transport |
| Cellular Component |
| plasma membrane |
| integral to membrane |
| integral to plasma membrane |
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| integral to plasma membrane |
| membrane |
| Function |
| neurotransmitter transporter activity |
| neurotransmitter:sodium symporter activity |
| taurine:sodium symporter activity |
| transmembrane transporter activity |
| transporter activity |
| Molecular Function |
| neurotransmitter:sodium symporter activity |
| taurine binding |
| taurine:sodium symporter activity |
| Process |
| establishment of localization |
| transport |
| neurotransmitter transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3p25.1 |
| SNPs
| SLC6A6 |
| Gene Sequence
|
>1863 bp
ATGGCCACCAAGGAGAAGCTGCAGTGTCTGAAAGATTTCCACAAGGACATCCTGAAGCCC
TCACCAGGGAAGAGCCCAGGCACGCGGCCTGAGGACGAGGCTGAGGGAAAACCTCCGCAG
AGGGAGAAGTGGTCTAGCAAGATCGACTTTGTGCTCTCTGTGGCTGGCGGCTTCGTGGGC
TTGGGCAACGTCTGGCGCTTCCCGTACCTCTGCTACAAGAATGGTGGAGGTGCGTTTCTC
ATACCGTATTTTATTTTCCTGTTTGGGAGCGGCCTGCCTGTGTTTTTCTTGGAGATCATC
ATAGGCCAGTACACCTCTGAAGGGGGCATCACCTGCTGGGAAAAGATCTGCCCCTTGTTC
TCTGGTATCGGCTATGCCTCCGTTGTAATTGTGTCCCTCCTGAATGTCTACTACATCGTC
ATCCTGGCCTGGGCCACATACTACCTGTTCCAGTCCTTCCAGAAGGAGCTGCCCTGGGCA
CACTGCAACCACAGCTGGAACACACCTCACTGCATGGAGGACACCATGCGCAAGAACAAG
AGTGTCTGGATCACCATCAGCTCCACCAACTTCACCTCCCCTGTCATCGAGTTCTGGGAG
CGCAACGTGCTGAGCTTGTCCCCTGGAATCGACCACCCAGGCTCTCTGAAATGGGACCTC
GCTCTCTGCCTTCTTTTAGTCTGGCTAGTGTGTTTCTTCTGCATCTGGAAGGGCGTCAGG
TCCACTGGGAAGGTCGTCTACTTCACAGCCACTTTTCCATTCGCCATGCTCCTGGTGCTG
CTGGTCCGAGGGCTGACGCTGCCGGGCGCGGGCGCAGGCATCAAGTTCTATCTGTATCCT
GACATCACCCGCCTTGAGGACCCACAGGTGTGGATTGACGCTGGGACTCAGATATTCTTC
TCTTATGCCATCTGCCTGGGGGCTATGACCTCGCTGGGGAGCTACAACAAGTACAAGTAT
AACTCGTACAGGGACTGTATGCTGCTGGGATGCCTGAACAGTGGTACCAGTTTTGTGTCT
GGCTTCGCAATTTTTTCCATCCTGGGCTTCATGGCACAAGAGCAAGGGGTGGACATTGCT
GATGTGGCTGAGTCAGGTCCTGGCCTGGCCTTCATTGCCTACCCAAAAGCTGTGACAATG
ATGCCGCTGCCCACATTTTGGTCCATTCTTTTTTTTATTATGCTTCTCTTGCTTGGACTG
GATAGCCAGTTTGTTGAAGTTGAAGGACAGATCACATCCTTGGTTGATCTTTACCCATCC
TTCCTAAGGAAGGGTTATCGTCGGGAAATCTTCATCGCCTTCGTGTGTAGCATCAGCTAC
CTGCTGGGGCTGACGATGGTGACGGAGGGTGGCATGTATGTGTTTCAGCTCTTTGACTAC
TATGCAGCTAGCGGTGTATGCCTTTTGTGGGTTGCATTCTTTGAATGTTTTGTTATTGCC
TGGATATATGGAGGTGATAACCTTTATGATGGTATTGAGGACATGATTGGCTATCGGCCC
GGGCCCTGGATGAAGTACAGCTGGGCTGTGATCACTCCAGTTCTCTGTGTTGGATGTTTC
ATCTTCTCGCTCGTCAAGTACGTACCCCTGACCTACAACAAAACATACGTGTACCCCAAC
TGGGCCATTGGGCTGGGCTGGAGCCTGGCCCTTTCCTCCATGCTCTGCGTTCCCTTGGTC
ATCGTCATCCGCCTCTGCCAGACTGAGGGGCCGTTCCTTGTGAGAGTCAAGTACCTGCTG
ACCCCAAGGGAACCCAACCGCTGGGCTGTGGAGCGCGAGGGAGCCACACCTTACAACTCT
CGCACCGTCATGAACGGCGCTCTCGTGAAACCGACCCACATCATTGTGGAGACCATGATG
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 620 |
| Molecular Weight
| 69829.405 |
| Theoretical pI
| 7.393 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Sodium- and chloride-dependent taurine transporter
MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVG
LGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLF
SGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNK
SVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVR
STGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFF
SYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIA
DVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPS
FLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIA
WIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPN
WAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREPNRWAVEREGATPYNS
RTVMNGALVKPTHIIVETMM
|
| External Links |
|---|
| GenBank ID Protein
| 197276623 |
| UniProtKB/Swiss-Prot ID
| P31641 |
| UniProtKB/Swiss-Prot Entry Name
| SC6A6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001134367.1 |
| GeneCard ID
| SLC6A6 |
| GenAtlas ID
| SLC6A6 |
| HGNC ID
| HGNC:11052 |
| References |
|---|
| General References
| Not Available |