| Identification |
|---|
| HMDB Protein ID
| CDBP02136 |
| Secondary Accession Numbers
| Not Available |
| Name
| Aquaporin-2 |
| Description
| Not Available |
| Synonyms
|
- ADH water channel
- AQP-2
- AQP-CD
- Aquaporin-CD
- Collecting duct water channel protein
- WCH-CD
- Water channel protein for renal collecting duct
|
| Gene Name
| AQP2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transporter activity |
| Specific Function
| Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient |
| GO Classification
|
| Component |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| transporter activity |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Multi-pass membrane protein
- Multi-pass membrane protein
- Apical cell membrane
- Cytoplasmic vesicle membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Kidney Function |    | Not Available | | Glucose Transporter Defect (SGLT2) |    | Not Available | | Hartnup Disorder |    | Not Available | | Iminoglycinuria |    | Not Available | | Lysinuric Protein Intolerance |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q12-q13 |
| SNPs
| AQP2 |
| Gene Sequence
|
>816 bp
ATGTGGGAGCTCCGCTCCATAGCCTTCTCCAGGGCTGTGTTCGCAGAGTTCCTGGCCACA
CTCCTCTTCGTCTTCTTTGGCCTCGGCTCTGCCCTCAACTGGCCACAGGCCCTGCCCTCT
GTGCTACAGATTGCCATGGCGTTTGGCTTGGGTATTGGCACCCTGGTACAGGCTCTGGGC
CACATAAGCGGGGCCCACATCAACCCTGCCGTGACTGTGGCCTGCCTGGTGGGCTGCCAC
GTCTCCGTTCTCCGAGCCGCCTTCTACGTGGCTGCCCAGCTGCTGGGGGCTGTGGCCGGA
GCCGCTCTGCTCCATGAGATCACGCCAGCAGACATCCGCGGGGACCTGGCTGTCAATGCT
CTCAGCAACAGCACGACGGCTGGCCAGGCGGTGACTGTGGAGCTCTTCCTGACACTGCAG
CTGGTGCTCTGCATCTTCGCCTCCACCGATGAGCGCCGCGGAGAGAACCCGGGCACCCCT
GCTCTCTCCATAGGCTTCTCCGTGGCCCTGGGCCACCTCCTTGGGATCCATTACACCGGC
TGCTCTATGAATCCTGCCTGCTCCCTGGCTCCAGCTGTCGTCACTGGCAAATTTGATGAC
CACTGGGTCTTCTGGATCGGACCCCTGGTGGGCGCCATCCTGGGCTCCCTCCTCTACAAC
TACGTGCTGTTTCCGCCAGCCAAGAGCCTGTCGGAGCGCCTGGCAGTGCTGAAGGGCCTG
GAGCCGGACACCGATTGGGAGGAGCGCGAGGTGCGACGGCGGCAGTCGGTGGAGCTGCAC
TCGCCGCAGAGCCTGCCACGGGGTACCAAGGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 271 |
| Molecular Weight
| 28837.2 |
| Theoretical pI
| 6.95 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["17-34", "41-59", "86-107", "128-148", "157-176", "203-224"]
|
| Protein Sequence
|
>Aquaporin-2
MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALG
HISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNA
LSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTG
CSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGL
EPDTDWEEREVRRRQSVELHSPQSLPRGTKA
|
| External Links |
|---|
| GenBank ID Protein
| 685001 |
| UniProtKB/Swiss-Prot ID
| P41181 |
| UniProtKB/Swiss-Prot Entry Name
| AQP2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| S73196 |
| GeneCard ID
| AQP2 |
| GenAtlas ID
| AQP2 |
| HGNC ID
| HGNC:634 |
| References |
|---|
| General References
| Not Available |