| Identification |
|---|
| HMDB Protein ID
| CDBP02131 |
| Secondary Accession Numbers
| Not Available |
| Name
| 17-beta-hydroxysteroid dehydrogenase type 6 |
| Description
| Not Available |
| Synonyms
|
- 17-beta-HSD 6
- 17-beta-HSD6
- 3-alpha->beta-HSE
- 3-alpha->beta-hydroxysteroid epimerase
- Oxidative 3-alpha hydroxysteroid dehydrogenase
|
| Gene Name
| HSD17B6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.
|
| GO Classification
|
| Biological Process |
| androgen catabolic process |
| androgen biosynthetic process |
| Cellular Component |
| intracellular |
| endoplasmic reticulum |
| early endosome membrane |
| Function |
| binding |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| testosterone dehydrogenase (NAD+) activity |
| estradiol 17-beta-dehydrogenase activity |
| nucleotide binding |
| electron carrier activity |
| retinol dehydrogenase activity |
| oxidoreductase activity |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Peripheral membrane protein
- Peripheral membrane protein
- Lumenal side
- Microsome membrane
- Early endosome membrane
- Lumenal side (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Steroid hormone biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q13 |
| SNPs
| HSD17B6 |
| Gene Sequence
|
>954 bp
ATGTGGCTCTACCTGGCAGCCTTCGTGGGCCTGTACTACCTTCTGCACTGGTACCGGGAG
AGGCAGGTGGTGAGCCACCTCCAAGACAAGTATGTCTTTATCACGGGCTGTGACTCGGGC
TTTGGGAACCTACTGGCCAGACAGCTGGATGCACGAGGCTTGAGAGTGCTGGCTGCGTGT
CTGACGGAGAAGGGGGCCGAGCAGCTGAGGGGCCAGACGTCTGACAGGCTGGAGACGGTG
ACCCTGGATGTTACCAAGATGGAGAGCATCGCTGCAGCTACTCAGTGGGTGAAGGAGCAT
GTGGGGGACAGAGGACTCTGGGGACTGGTGAACAATGCAGGCATTCTTACACCAATTACC
TTATGTGAGTGGCTGAACACTGAGGACTCTATGAATATGCTCAAAGTGAACCTCATTGGT
GTGATCCAGGTGACCTTGAGCATGCTTCCTTTGGTGAGGAGAGCACGGGGAAGAATTGTC
AATGTCTCCAGCATTCTGGGAAGAGTTGCTTTCTTTGTAGGAGGCTACTGTGTCTCCAAG
TATGGAGTGGAAGCCTTTTCAGATATTCTGAGGCGTGAGATTCAACATTTTGGGGTGAAA
ATCAGCATAGTTGAACCTGGCTACTTCAGAACGGGAATGACAAACATGACACAGTCCTTA
GAGCGAATGAAGCAAAGTTGGAAAGAAGCCCCCAAGCATATTAAGGAGACCTATGGACAG
CAGTATTTTGATGCCCTTTACAATATCATGAAGGAAGGGCTGTTGAATTGTAGCACAAAC
CTGAACCTGGTCACTGACTGCATGGAACATGCTCTGACATCGGTGCATCCGCGAACTCGA
TATTCAGCTGGCTGGGATGCTAAATTTTTCTTCATCCCTCTATCTTATTTACCTACATCA
CTGGCAGACTACATTTTGACTAGATCTTGGCCCAAACCAGCCCAGGCAGTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 317 |
| Molecular Weight
| 35965.41 |
| Theoretical pI
| 8.728 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>17-beta-hydroxysteroid dehydrogenase type 6
MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC
LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT
LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK
YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ
QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS
LADYILTRSWPKPAQAV
|
| External Links |
|---|
| GenBank ID Protein
| 2338748 |
| UniProtKB/Swiss-Prot ID
| O14756 |
| UniProtKB/Swiss-Prot Entry Name
| H17B6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF016509 |
| GeneCard ID
| HSD17B6 |
| GenAtlas ID
| HSD17B6 |
| HGNC ID
| HGNC:23316 |
| References |
|---|
| General References
| Not Available |