Cannabis Compound Database: Showing Protein Dual specificity protein phosphatase 2 (CDBP02113)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP02113

Secondary Accession Numbers

Not Available

Name

Dual specificity protein phosphatase 2

Description

Not Available

Synonyms

Dual specificity protein phosphatase PAC-1

Gene Name

DUSP2

Protein Type

Enzyme

Biological Properties

General Function

Involved in phosphatase activity

Specific Function

Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.

GO Classification

Biological Process
regulation of apoptotic process
endoderm formation
Cellular Component
nucleoplasm
Function
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
map kinase tyrosine/serine/threonine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
Molecular Function
MAP kinase tyrosine/serine/threonine phosphatase activity
protein tyrosine/threonine phosphatase activity
protein tyrosine phosphatase activity
Process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
phosphorus metabolic process

Cellular Location

Nucleus

Pathways

Name	SMPDB/Pathwhiz	KEGG
MAPK signaling pathway	Not Available

Gene Properties

Chromosome Location

Locus

2q11

SNPs

DUSP2

Gene Sequence

>945 bp
ATGGGGCTGGAGGCGGCGCGCGAGCTGGAGTGCGCGGCGCTGGGCACGCTGCTGCGGGAT
CCGCGGGAGGCGGAACGCACGCTGCTGCTGGACTGCCGCCCCTTCCTGGCCTTCTGCCGG
CGCCACGTGCGCGCCGCGCGGCCAGTGCCTTGGAACGCGCTGCTGCGGCGCCGCGCGCGC
GGCCCTCCTGCCGCCGTTCTCGCCTGCCTGCTGCCCGACCGCGCGCTGCGGACGCGCCTG
GTCCGCGGGGAGCTGGCGCGGGCCGTGGTGCTGGACGAGGGCAGTGCCTCGGTGGCGGAG
CTCCGGCCCGACAGCCCGGCTCATGTGCTGCTGGCCGCGCTGCTGCACGAGACCCGCGCG
GGGCCCACTGCCGTGTACTTCCTGCGAGGAGGCTTCGACGGCTTCCAGGGCTGCTGTCCC
GATCTGTGCTCTGAGGCCCCCGCCCCTGCGCTGCCGCCAACAGGGGACAAAACCAGCCGC
TCCGACTCCAGGGCTCCTGTCTACGACCAGGGTGGCCCTGTGGAGATCTTGCCCTACCTG
TTCCTGGGCAGCTGCAGTCACTCGTCAGACCTGCAGGGGCTGCAGGCCTGTGGCATCACA
GCCGTCCTCAACGTGTCCGCCAGCTGCCCCAACCACTTTGAGGGCCTTTTCCGCTACAAG
AGTATCCCTGTGGAGGACAACCAGATGGTGGAGATCAGTGCCTGGTTCCAGGAGGCCATA
GGCTTCATTGACTGGGTGAAGAACAGCGGAGGCCGGGTGCTGGTGCACTGCCAGGCGGGT
ATCTCGCGCTCTGCCACCATCTGTCTGGCATACCTCATGCAGAGTCGCCGTGTGCGGCTG
GACGAGGCCTTTGACTTCGTTAAGCAGCGCCGGGGGGTCATCTCCCCCAACTTCAGTTTC
ATGGGGCAGCTGCTGCAGTTTGAGACCCAGGTGCTGTGTCACTGA

Protein Properties

Number of Residues

314

Molecular Weight

34399.195

Theoretical pI

7.924

Pfam Domain Function

Rhodanese (PF00581 )
DSPc (PF00782 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Dual specificity protein phosphatase 2
MGLEAARELECAALGTLLRDPREAERTLLLDCRPFLAFCRRHVRAARPVPWNALLRRRAR
GPPAAVLACLLPDRALRTRLVRGELARAVVLDEGSASVAELRPDSPAHVLLAALLHETRA
GPTAVYFLRGGFDGFQGCCPDLCSEAPAPALPPTGDKTSRSDSRAPVYDQGGPVEILPYL
FLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAI
GFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSF
MGQLLQFETQVLCH

External Links

GenBank ID Protein

62988835

UniProtKB/Swiss-Prot ID

Q05923

UniProtKB/Swiss-Prot Entry Name

DUS2_HUMAN

PDB IDs