Identification |
HMDB Protein ID
| CDBP02102 |
Secondary Accession Numbers
| Not Available |
Name
| Sialin |
Description
| Not Available |
Synonyms
|
- AST
- Membrane glycoprotein HP59
- Sodium/sialic acid cotransporter
- Solute carrier family 17 member 5
|
Gene Name
| SLC17A5 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in transmembrane transport |
Specific Function
| Primary solute translocator for anionic substances; particularly it is a free sialic acid transporter in the lysosomes (Probable) |
GO Classification
|
Process |
establishment of localization |
transport |
transmembrane transport |
|
Cellular Location
|
- Lysosome membrane
- Multi-pass membrane protein
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Amino Sugar Metabolism |    |  | Sialuria or French Type Sialuria |    | Not Available | Salla Disease/Infantile Sialic Acid Storage Disease |    | Not Available | Tay-Sachs Disease |    | Not Available | G(M2)-Gangliosidosis: Variant B, Tay-sachs disease |    | Not Available |
|
Gene Properties |
Chromosome Location
| Chromosome:6 |
Locus
| 6q14-q15 |
SNPs
| SLC17A5 |
Gene Sequence
|
>1488 bp
ATGAGGTCTCCGGTTCGAGACCTGGCCCGGAACGATGGCGAGGAGAGCACGGACCGCACG
CCTCTTCTACCGGGCGCCCCACGGGCCGAAGCCGCTCCAGTGTGCTGCTCTGCTCGTTAC
AACTTAGCAATTTTGGCCTTTTTTGGTTTCTTCATTGTGTATGCATTACGTGTGAATCTG
AGTGTTGCGTTAGTGGATATGGTAGATTCAAATACAACTTTAGAAGATAATAGAACTTCC
AAGGCGTGTCCAGAGCATTCTGCTCCCATAAAAGTTCATCATAATCAAACGGGTAAGAAG
TACCAATGGGATGCAGAAACTCAAGGATGGATTCTCGGTTCCTTTTTTTATGGCTACATC
ATCACACAGATTCCTGGAGGATATGTTGCCAGCAAAATAGGGGGGAAAATGCTGCTAGGA
TTTGGGATCCTTGGCACTGCTGTCCTCACCCTGTTCACTCCCATTGCTGCAGATTTAGGA
GTTGGACCACTCATTGTACTCAGAGCACTAGAAGGACTAGGAGAGGGTGTTACATTTCCA
GCCATGCATGCCATGTGGTCTTCTTGGGCTCCCCCTCTTGAAAGAAGCAAACTTCTTAGC
ATTTCATATGCAGGAGCACAGCTTGGGACAGTAATTTCTCTTCCTCTTTCTGGAATAATT
TGCTACTATATGAATTGGACTTATGTCTTCTACTTTTTTGGTACTATTGGAATATTTTGG
TTTCTTTTGTGGATCTGGTTAGTTAGTGACACACCACAAAAACACAAGAGAATTTCCCAT
TATGAAAAGGAATACATTCTTTCATCATTAAGAAATCAGCTTTCTTCACAGAAGTCAGTG
CCGTGGGTACCCATTTTAAAATCCCTGCCACTTTGGGCTATCGTAGTTGCACACTTTTCT
TACAACTGGACTTTTTATACTTTATTGACATTATTGCCTACTTATATGAAGGAGATCCTA
AGGTTCAATGTTCAAGAGAATGGGTTTTTATCTTCATTGCCTTATTTAGGCTCTTGGTTA
TGTATGATCCTGTCTGGTCAAGCTGCTGACAATTTAAGGGCAAAATGGAATTTTTCAACT
TTATGTGTTCGCAGAATTTTTAGCCTTATAGGAATGATTGGACCTGCAGTATTCCTGGTA
GCTGCTGGCTTCATTGGCTGTGATTATTCTTTGGCCGTTGCTTTCCTAACTATATCAACA
ACACTGGGAGGCTTTTGCTCTTCTGGATTTAGCATCAACCATCTGGATATTGCTCCTTCG
TATGCTGGTATCCTCCTGGGCATCACAAATACATTTGCCACTATTCCAGGAATGGTTGGG
CCCGTCATTGCTAAAAGTCTGACCCCTGATAACACTGTTGGAGAATGGCAAACCGTGTTC
TATATTGCTGCTGCTATTAATGTTTTTGGTGCCATTTTCTTTACACTATTCGCCAAAGGT
GAAGTACAAAACTGGGCTCTCAATGATCACCATGGACACAGACACTGA
|
Protein Properties |
Number of Residues
| 495 |
Molecular Weight
| 54639.0 |
Theoretical pI
| 8.36 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
- ["42-62", "110-130", "137-157", "159-179", "201-221", "228-248", "280-300", "329-349", "366-386", "392-412", "424-444", "458-478"]
|
Protein Sequence
|
>Sialin
MRSPVRDLARNDGEESTDRTPLLPGAPRAEAAPVCCSARYNLAILAFFGFFIVYALRVNL
SVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYI
ITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFP
AMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFW
FLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQKSVPWVPILKSLPLWAIVVAHFS
YNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFST
LCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPS
YAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKG
EVQNWALNDHHGHRH
|
External Links |
GenBank ID Protein
| 6912666 |
UniProtKB/Swiss-Prot ID
| Q9NRA2 |
UniProtKB/Swiss-Prot Entry Name
| S17A5_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_012434.4 |
GeneCard ID
| SLC17A5 |
GenAtlas ID
| SLC17A5 |
HGNC ID
| HGNC:10933 |
References |
General References
| Not Available |