| Identification |
|---|
| HMDB Protein ID
| CDBP02102 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sialin |
| Description
| Not Available |
| Synonyms
|
- AST
- Membrane glycoprotein HP59
- Sodium/sialic acid cotransporter
- Solute carrier family 17 member 5
|
| Gene Name
| SLC17A5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transmembrane transport |
| Specific Function
| Primary solute translocator for anionic substances; particularly it is a free sialic acid transporter in the lysosomes (Probable) |
| GO Classification
|
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Lysosome membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Amino Sugar Metabolism |    |  | | Sialuria or French Type Sialuria |    | Not Available | | Salla Disease/Infantile Sialic Acid Storage Disease |    | Not Available | | Tay-Sachs Disease |    | Not Available | | G(M2)-Gangliosidosis: Variant B, Tay-sachs disease |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6q14-q15 |
| SNPs
| SLC17A5 |
| Gene Sequence
|
>1488 bp
ATGAGGTCTCCGGTTCGAGACCTGGCCCGGAACGATGGCGAGGAGAGCACGGACCGCACG
CCTCTTCTACCGGGCGCCCCACGGGCCGAAGCCGCTCCAGTGTGCTGCTCTGCTCGTTAC
AACTTAGCAATTTTGGCCTTTTTTGGTTTCTTCATTGTGTATGCATTACGTGTGAATCTG
AGTGTTGCGTTAGTGGATATGGTAGATTCAAATACAACTTTAGAAGATAATAGAACTTCC
AAGGCGTGTCCAGAGCATTCTGCTCCCATAAAAGTTCATCATAATCAAACGGGTAAGAAG
TACCAATGGGATGCAGAAACTCAAGGATGGATTCTCGGTTCCTTTTTTTATGGCTACATC
ATCACACAGATTCCTGGAGGATATGTTGCCAGCAAAATAGGGGGGAAAATGCTGCTAGGA
TTTGGGATCCTTGGCACTGCTGTCCTCACCCTGTTCACTCCCATTGCTGCAGATTTAGGA
GTTGGACCACTCATTGTACTCAGAGCACTAGAAGGACTAGGAGAGGGTGTTACATTTCCA
GCCATGCATGCCATGTGGTCTTCTTGGGCTCCCCCTCTTGAAAGAAGCAAACTTCTTAGC
ATTTCATATGCAGGAGCACAGCTTGGGACAGTAATTTCTCTTCCTCTTTCTGGAATAATT
TGCTACTATATGAATTGGACTTATGTCTTCTACTTTTTTGGTACTATTGGAATATTTTGG
TTTCTTTTGTGGATCTGGTTAGTTAGTGACACACCACAAAAACACAAGAGAATTTCCCAT
TATGAAAAGGAATACATTCTTTCATCATTAAGAAATCAGCTTTCTTCACAGAAGTCAGTG
CCGTGGGTACCCATTTTAAAATCCCTGCCACTTTGGGCTATCGTAGTTGCACACTTTTCT
TACAACTGGACTTTTTATACTTTATTGACATTATTGCCTACTTATATGAAGGAGATCCTA
AGGTTCAATGTTCAAGAGAATGGGTTTTTATCTTCATTGCCTTATTTAGGCTCTTGGTTA
TGTATGATCCTGTCTGGTCAAGCTGCTGACAATTTAAGGGCAAAATGGAATTTTTCAACT
TTATGTGTTCGCAGAATTTTTAGCCTTATAGGAATGATTGGACCTGCAGTATTCCTGGTA
GCTGCTGGCTTCATTGGCTGTGATTATTCTTTGGCCGTTGCTTTCCTAACTATATCAACA
ACACTGGGAGGCTTTTGCTCTTCTGGATTTAGCATCAACCATCTGGATATTGCTCCTTCG
TATGCTGGTATCCTCCTGGGCATCACAAATACATTTGCCACTATTCCAGGAATGGTTGGG
CCCGTCATTGCTAAAAGTCTGACCCCTGATAACACTGTTGGAGAATGGCAAACCGTGTTC
TATATTGCTGCTGCTATTAATGTTTTTGGTGCCATTTTCTTTACACTATTCGCCAAAGGT
GAAGTACAAAACTGGGCTCTCAATGATCACCATGGACACAGACACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 495 |
| Molecular Weight
| 54639.0 |
| Theoretical pI
| 8.36 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["42-62", "110-130", "137-157", "159-179", "201-221", "228-248", "280-300", "329-349", "366-386", "392-412", "424-444", "458-478"]
|
| Protein Sequence
|
>Sialin
MRSPVRDLARNDGEESTDRTPLLPGAPRAEAAPVCCSARYNLAILAFFGFFIVYALRVNL
SVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYI
ITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFP
AMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFW
FLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQKSVPWVPILKSLPLWAIVVAHFS
YNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFST
LCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPS
YAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKG
EVQNWALNDHHGHRH
|
| External Links |
|---|
| GenBank ID Protein
| 6912666 |
| UniProtKB/Swiss-Prot ID
| Q9NRA2 |
| UniProtKB/Swiss-Prot Entry Name
| S17A5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_012434.4 |
| GeneCard ID
| SLC17A5 |
| GenAtlas ID
| SLC17A5 |
| HGNC ID
| HGNC:10933 |
| References |
|---|
| General References
| Not Available |