| Identification |
|---|
| HMDB Protein ID
| CDBP02067 |
| Secondary Accession Numbers
| Not Available |
| Name
| Translocator protein |
| Description
| Not Available |
| Synonyms
|
- Mitochondrial benzodiazepine receptor
- PBR
- PKBS
- Peripheral-type benzodiazepine receptor
|
| Gene Name
| TSPO |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells |
| GO Classification
|
| Component |
| intrinsic to membrane |
| integral to membrane |
| cell part |
| membrane part |
|
| Cellular Location
|
- Mitochondrion membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 22q13.31 |
| SNPs
| TSPO |
| Gene Sequence
|
>510 bp
ATGGCCCCGCCCTGGGTGCCCGCCATGGGCTTCACGCTGGCGCCCAGCCTGGGGTGCTTC
GTGGGCTCCCGCTTTGTCCACGGCGAGGGTCTCCGCTGGTACGCCGGCCTGCAGAAGCCC
TCGTGGCACCCGCCCCACTGGGTGCTGGGCCCTGTCTGGGGCACGCTCTACTCAGCCATG
GGGTACGGCTCCTACCTGGTCTGGAAAGAGCTGGGAGGCTTCACAGAGAAGGCTGTGGTT
CCCCTGGGCCTCTACACTGGGCAGCTGGCCCTGAACTGGGCATGGCCCCCCATCTTCTTT
GGTGCCCGACAAATGGGCTGGGCCTTGGTGGATCTCCTGCTGGTCAGTGGGGCGGCGGCN
GCCACTACCGTGGCCTGGTACCAGGTGAGCCCGCTGGCCGCCCGCCTGCTCTACCCCTAC
CTGGCCTGGCTGGCCTTCGCGACCACACTCAACTACTGCGTATGGCGGGACAACCATGGC
TGGCATGGGGGACGGCGGCTGCCAGAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 169 |
| Molecular Weight
| 18778.7 |
| Theoretical pI
| 9.33 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["6-26", "47-67", "80-100", "106-126", "135-155"]
|
| Protein Sequence
|
>Translocator protein
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAM
GYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAA
ATTVAWYQVSPLAARLLYPYLAWLAFATTLNYCVWRDNHGWHGGRRLPE
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P30536 |
| UniProtKB/Swiss-Prot Entry Name
| TSPOA_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M36035 |
| GeneCard ID
| TSPO |
| GenAtlas ID
| TSPO |
| HGNC ID
| HGNC:1158 |
| References |
|---|
| General References
| Not Available |