| Identification |
|---|
| HMDB Protein ID
| CDBP02024 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cortistatin |
| Description
| Not Available |
| Synonyms
|
- Cortistatin-17
- Cortistatin-29
|
| Gene Name
| CORT |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in hormone activity |
| Specific Function
| Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs |
| GO Classification
|
| Component |
| extracellular region |
| Function |
| hormone activity |
| binding |
| protein binding |
| receptor binding |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p36|1p36.22 |
| SNPs
| CORT |
| Gene Sequence
|
>318 bp
ATGCCATTGTCCCCCGGCCTCCTGCTGCTGCTGCTCTCCGGGGCCACGGCCACCGCTGCC
CTGCCCCTGGAGGGTGGCCCCACCGGCCGAGACAGCGAGCATATGCAGGAAGCGGCAGGA
ATAAGGAAAAGCAGCCTCCTGACTTTCCTCGCTTGGTGGTTTGAGTGGACCTCCCAGGCC
AGTGCCGGGCCCCTCATAGGAGAGGAAGCTCGGGAGGTGGCCAGGCGGCAGGAAGGCGCA
CCCCCCCAGCAATCCGCGCGCCGGGACAGAATGCCCTGCAGGAACTTCTTCTGGAAGACC
TTCTCCTCCTGCAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 105 |
| Molecular Weight
| 11532.0 |
| Theoretical pI
| 8.82 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cortistatin
MPLSPGLLLLLLSGATATAALPLEGGPTGRDSEHMQEAAGIRKSSLLTFLAWWFEWTSQA
SAGPLIGEEAREVARRQEGAPPQQSARRDRMPCRNFFWKTFSSCK
|
| External Links |
|---|
| GenBank ID Protein
| 2055232 |
| UniProtKB/Swiss-Prot ID
| O00230 |
| UniProtKB/Swiss-Prot Entry Name
| CORT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB000263 |
| GeneCard ID
| CORT |
| GenAtlas ID
| CORT |
| HGNC ID
| HGNC:2257 |
| References |
|---|
| General References
| Not Available |