| Identification |
|---|
| HMDB Protein ID
| CDBP02020 |
| Secondary Accession Numbers
| Not Available |
| Name
| Solute carrier family 52, riboflavin transporter, member 1 |
| Description
| Not Available |
| Synonyms
|
- PERV-A receptor 2
- Porcine endogenous retrovirus A receptor 2
- Protein GPR172B
- hRFT1
- Riboflavin transporter 1
|
| Gene Name
| SLC52A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in receptor activity |
| Specific Function
| Riboflavin transporter. Riboflavin transport is Na(+)-independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).
|
| GO Classification
|
| Cellular Component |
| integral to plasma membrane |
| Molecular Function |
| riboflavin transporter activity |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17p13.2 |
| SNPs
| GPR172B |
| Gene Sequence
|
>1347 bp
ATGGCAGCACCCACGCTGGGCCGTCTGGTGCTGACCCACCTGCTGGTGGCCCTTTTTGGC
ATGGGCTCCTGGGCTGCTGTGAACGGGATCTGGGTGGAGCTGCCTGTGGTGGTAAAAGAC
CTTCCAGAGGGTTGGAGCCTCCCCTCATACCTCTCTGTGGTTGTGGCGCTGGGAAACCTG
GGTCTGCTGGTGGTGACCCTGTGGAGGCGGCTGGCCCCGGGCAAGGGCGAGCAGGTCCCC
ATCCAGGTGGTACAGGTGCTGAGTGTAGTGGGCACAGCCCTGCTGGCCCCTCTGTGGCAC
CACGTGGCCCCAGTGGCAGGGCAGCTCCACTCTGTGGCCTTCCTAACTCTGGCCTTGGTG
TTGGCAATGGCCTGTTGTACCTCTAATGTCACTTTCCTGCCCTTCCTGAGCCACCTGCCA
CCTCCTTTCTTACGGTCTTTCTTCCTGGGTCAGGGTCTCAGTGCCCTACTCCCCTGTGTG
CTGGCCCTAGTGCAAGGTGTGGGCCGCCTCGAGTGCCCACCAGCGCCCACCAATGGCACC
TCTGGGCCTCCCCTCGACTTCCCTGAGCGTTTTCCTGCCAGCACCTTCTTCTGGGCACTG
ACTGCCCTTCTGGTCACTTCAGCTGCCGCCTTCCGGGGTCTCCTGTTGCTGTTGCCATCA
CTACCCTCTGTAACCACAGGGGGCTCAGGGCCTGAACTTCAACTGGGATCCCCAGGAGCA
GAGGAGGAAGAGAAGGAGGAAGAAGAGGCTTTGCCATTGCAGGAGCCACCGAGCCAGGCA
GCAGGCACCATCCCTGGCCCAGACCCTGAGGTCCATCAGCTGTTCTCAGCCCATGGTGCC
TTCCTGCTGGGCCTGATGGCCTTCACCAGTGCCGTGACCAATGGCGTGCTGCCTTCTGTG
CAGAGCTTTTCCTGTTTGCCCTATGGGCGCCTGGCCTACCACCTGGCTGTGGTGCTGGGC
AGTGCCGCCAACCCCCTTGCCTGCTTCCTGGCCATGGGCGTGCTGTGCAGGTCCCTGGCA
GGGCTGGTTGGTCTTTCTCTGCTGGGCATGCTCTTTGGGGCCTACCTGATGGCACTGGCA
ATCCTGAGCCCCTGCCCACCCCTGGTGGGCACCACTGCAGGGGTGGTCCTTGTGGTGCTG
TCGTGGGTGCTGTGTCTGTGTGTGTTCTCATATGTGAAGGTGGCTGCAAGCTCCCTGCTG
CATGGTGGGGGTCGGCCGGCATTGCTGGCAGCTGGTGTGGCCATCCAAGTGGGCTCCCTG
CTTGGTGCCGGTGCCATGTTCCCTCCCACCAGCATCTACCACGTGTTTCAAAGCAGAAAG
GACTGTGTAGACCCCTGTGGCCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 448 |
| Molecular Weight
| 46316.245 |
| Theoretical pI
| 6.347 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Riboflavin transporter 1
MAAPTLGRLVLTHLLVALFGMGSWAAVNGIWVELPVVVKDLPEGWSLPSYLSVVVALGNL
GLLVVTLWRQLAPGKGEQVPIQVVQVLSVVGTALLAPLWHHVAPVAGQLHSVAFLTLALV
LAMACCTSNVTFLPFLSHLPPPFLRSFFLGQGLSALLPCVLALVQGVGRLECPPAPTNGT
SGPPLDFPERFPASTFFWALTALLVTSAAAFRGLLLLLPSLPSVTTGGSGPELQLGSPGA
EEEEKEEEEALPLQEPPSQAAGTIPGPDPEAHQLFSAHGAFLLGLMAFTSAVTNGVLPSV
QSFSCLPYGRLAYHLAVVLGSAANPLACFLAMGVLCRSLAGLVGLSLLGMLFGAYLMALA
ILSPCPPLVGTTAGVVLVVLSWVLCLCVFSYVKVAASSLLHGGGRPALLAAGVAIQVGSL
LGAGAMFPPTSIYHVFQSRKDCVDPCGP
|
| External Links |
|---|
| GenBank ID Protein
| 204022240 |
| UniProtKB/Swiss-Prot ID
| Q9NWF4 |
| UniProtKB/Swiss-Prot Entry Name
| RFT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB362533 |
| GeneCard ID
| GPR172B |
| GenAtlas ID
| GPR172B |
| HGNC ID
| HGNC:30225 |
| References |
|---|
| General References
| Not Available |