| Identification |
|---|
| HMDB Protein ID
| CDBP02011 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cytochrome b-245 light chain |
| Description
| Not Available |
| Synonyms
|
- Cytochrome b(558) alpha chain
- Cytochrome b558 subunit alpha
- Neutrophil cytochrome b 22 kDa polypeptide
- Superoxide-generating NADPH oxidase light chain subunit
- p22 phagocyte B-cytochrome
- p22-phox
- p22phox
|
| Gene Name
| CYBA |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in heme binding |
| Specific Function
| Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| iron ion binding |
| heme binding |
|
| Cellular Location
|
- Membrane (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Tyrosine Metabolism |    |  | | Thyroid hormone synthesis |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16q24 |
| SNPs
| CYBA |
| Gene Sequence
|
>588 bp
ATGGGGCAGATCGAGTGGGCCATGTGGGCCAACGAACAGGCGCTGGCGTCCGGCCTGATC
CTCATCACCGGGGGCATCGTGGCCACAGCTGGGCGCTTCACCCAGTGGTACTTTGGTGCC
TACTCCATTGTGGCGGGCGTGTTTGTGTGCCTGCTGGAGTACCCCCGGGGGAAGAGGAAG
AAGGGCTCCACCATGGAGCGCTGGGGACAGAAGTACATGACCGCCGTGGTGAAGCTGTTC
GGGCCCTTTACCAGGAATTACTATGTTCGGGCCGTCCTGCATCTCCTGCTCTCGGTGCCC
GCCGGCTTCCTGCTGGCCACCATCCTTGGGACCGCCTGCCTGGCCATTGCGAGCGGCATC
TACCTACTGGCGGCTGTGCGTGGCGAGCAGTGGACGCCCATCGAGCCCAAGCCCCGGGAG
CGGCCGCAGATCGGAGGCACCATCAAGCAGCCGCCCAGCAACCCCCCGCCGCGGCCCCCG
GCCGAGGCCCGCAAGAAGCCCAGCGAGGAGGAGGCTGCGGTGGCGGCGGGGGGACCCCCG
GGAGGTCCCCAGGTCAACCCCATCCCGGTGACCGACGAGGTCGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 195 |
| Molecular Weight
| 20958.3 |
| Theoretical pI
| 10.03 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cytochrome b-245 light chain
MGQIEWAMWANEQALASGLILITGGIVATAGRFTQWYFGAYSIVAGVFVCLLEYPRGKRK
KGSTMERWGQKHMTAVVKLFGPFTRNYYVRAVLHLLLSVPAGFLLATILGTACLAIASGI
YLLAAVRGEQWTPIEPKPRERPQIGGTIKQPPSNPPPRPPAEARKKPSEEEAAAAAGGPP
GGPQVNPIPVTDEVV
|
| External Links |
|---|
| GenBank ID Protein
| 68509914 |
| UniProtKB/Swiss-Prot ID
| P13498 |
| UniProtKB/Swiss-Prot Entry Name
| CY24A_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_000101.2 |
| GeneCard ID
| CYBA |
| GenAtlas ID
| CYBA |
| HGNC ID
| HGNC:2577 |
| References |
|---|
| General References
| Not Available |