Showing Protein Ribonuclease H2 subunit A (CDBP02010)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP02010
Secondary Accession Numbers Not Available
Name Ribonuclease H2 subunit A
Description Not Available
Synonyms
  1. AGS4
  2. Aicardi-Goutieres syndrome 4 protein
  3. RNase H(35)
  4. RNase H2 subunit A
  5. RNase HI large subunit
  6. Ribonuclease HI large subunit
  7. Ribonuclease HI subunit A
Gene Name RNASEH2A
Protein Type Enzyme
Biological Properties
General Function Involved in nucleic acid binding
Specific Function Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes
GO Classification
Function
hydrolase activity, acting on ester bonds
binding
catalytic activity
endoribonuclease activity, producing 5'-phosphomonoesters
hydrolase activity
ribonuclease h activity
nucleic acid binding
nuclease activity
endonuclease activity
endoribonuclease activity
rna binding
Process
macromolecule metabolic process
cellular macromolecule metabolic process
rna metabolic process
metabolic process
Cellular Location
  1. Nucleus (Probable)
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 19p13.2
SNPs RNASEH2A
Gene Sequence 
>900 bp
ATGGATCTCAGCGAGCTGGAGAGAGACAATACAGGCCGCTGTCGCCTGAGTTCGCCTGTG
CCCGCGGTGTGCCGCAAGGAGCCTTGCGTCCTGGGCGTCGATGAGGCGGGCAGGGGCCCC
GTGCTGGGCCCCATGGTCTACGCCATCTGTTATTGTCCCCTGCCTCGCCTGGCAGATCTG
GAGGCGCTGAAAGTGGCAGACTCAAAGACCCTATTGGAGAGCGAGCGGGAAAGGCTGTTT
GCGAAAATGGAGGACACGGACTTTGTCGGCTGGGCGCTGGATGTGCTGTCTCCAAACCTC
ATCTCTACCAGCATGCTTGGGCGGGTCAAATACAACCTGAACTCCCTGTCACATGATACA
GCCACTGGGCTTATACAGTATGCATTGGACCAGGGCGTGAACGTCACCCAGGTATTCGTG
GACACCGTAGGGATGCCAGAGACATACCAGGCGCAGCTGCAGCAAAGTTTTCCCGGGATT
GAGGTGACGGTCAAGGCCAAAGCAGATGCCCTCTACCCGGTGGTTAGTGCTGCCAGCATC
TGTGCCAAGGTGGCCCGGGACCAGGCCGTGAAGAAATGGCAGTTCGTGGAGAAACTGCAG
GACTTGGATACTGATTATGGCTCAGGCTACCCCAATGATCCCAAGACAAAAGCGTGGTTG
AAGGAGCACGTGGAGCCTGTGTTCGGCTTCCCCCAGTTTGTCCGGTTCAGCTGGCGCACG
GCCCAGACCATCCTGGAGAAAGAGGCGGAAGATGTTATATGGGAGGACTCAGCATCCGAG
AATCAGGAGGGACTCAGGAAGATCACATCCTACTTCCTCAATGAAGGGTCCCAAGCCCGT
CCCCGTTCTTCCCACCGATATTTCCTGGAACGCGGCCTGGAGTCAGCAACCAGCCTCTAG
Protein Properties
Number of Residues 299
Molecular Weight 33394.6
Theoretical pI 4.88
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Ribonuclease H2 subunit A
MDLSELERDNTGRCRLSSPVPAVCRKEPCVLGVDEAGRGPVLGPMVYAICYCPLPRLADL
EALKVADSKTLLESERERLFAKMEDTDFVGWALDVLSPNLISTSMLGRVKYNLNSLSHDT
ATGLIQYALDQGVNVTQVFVDTVGMPETYQARLQQSFPGIEVTVKAKADALYPVVSAASI
CAKVARDQAVKKWQFVEKLQDLDTDYGSGYPNDPKTKAWLKEHVEPVFGFPQFVRFSWRT
AQTILEKEAEDVIWEDSASENQEGLRKITSYFLNEGSQARPRSSHRYFLERGLESATSL
GenBank ID Protein 3334761
UniProtKB/Swiss-Prot ID O75792
UniProtKB/Swiss-Prot Entry Name RNH2A_HUMAN
PDB IDs Not Available
GenBank Gene ID Z97029
GeneCard ID RNASEH2A
GenAtlas ID RNASEH2A
HGNC ID HGNC:18518
References
General References Not Available