Cannabis Compound Database: Showing Protein Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) (CDBP01987)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP01987

Secondary Accession Numbers

Not Available

Name

Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)

Description

Not Available

Synonyms

ATP-dependent dihydroxyacetone kinase
DHA kinase
FAD-AMP lyase (cyclic FMN forming)
FAD-AMP lyase (cyclizing)
FMN cyclase
Glycerone kinase

Gene Name

DAK

Protein Type

Enzyme

Biological Properties

General Function

Carbohydrate transport and metabolism

Specific Function

Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate.

GO Classification

Biological Process
glycerol metabolic process
innate immune response
Cellular Component
cytosol
Function
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
glycerone kinase activity
binding
Molecular Function
metal ion binding
ATP binding
FAD-AMP lyase (cyclizing) activity
glycerone kinase activity
triokinase activity
Process
alcohol metabolic process
polyol metabolic process
alditol metabolic process
glycerol metabolic process
metabolic process
small molecule metabolic process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
RIG-I-like receptor signaling pathway	Not Available

Gene Properties

Chromosome Location

Locus

11q12.2

SNPs

DAK

Gene Sequence

>1728 bp
ATGACCTCCAAGAAGCTGGCGAACTCGGTGGCTGGCTGTGCTGATGACGCTCTTGCTGGC
CTGGTGGCCTGCAACCCCAACCTGCAGCTCCTGCAGGGCCACCGCGTGGCCCTCCGTTCT
GACCTGGACAGCCTCAAGGGCCGGGTGGCACTGCTGTCGGGTGGGGGCTCTGGCCATGAG
CCTGCCCATGCTGGTTTCATAGGGAAGGGGATGCTGACTGGGGCCATCGCGGGAGCTGTG
TTCACCTCCCCGGCAGTGGGCAGCATCCTGGCAGCCATCAGGGCCGTGGCCCAGGCCGGC
ACAGTGGGGACGCTCCTTATCGTGAAGAACTACACTGGGGATCGGCTCAACTTCGGCCTG
GCCCGGGAGCAGGCCCGGGCTGAAGGCATCCCGGTGGAGATGGTGGTGATTGGGGACGAC
AGCGCCTTCACTGTCCTGAAGAAGGCAGGCCGGCGGGGGCTGTGCGGCACCGTGCTTATA
CACAAGGTGGCAGGTGCTCTGGCTGAGGCTGGTGTGGGGCTGGAGGAGATCGCAAAGCAG
GTGAACGTGGTCACCAAGGCCATGGGTACCCTGGGGGTGAGCTTATCCTCCTGCAGCGTC
CCTGGTTCCAAACCCACCTTCGAGCTCTCAGCCGACGAGGTGGAGCTGGGCCTGGGGATC
CACGGGGAAGCTGGTGTGCGCCGGATAAAGATGGCAACCGCCGATGAGATTGTGAAACTC
ATGCTCGACCACATGACAAACACCACCAACGCGTCCCATGTGCCTGTGCAGCCCGGCTCC
TCAGTTGTGATGATGGTCAACAACCTGGGTGGCCTGTCATTCCTGGAACTGGGCATCATA
GCCGACGCTACCGTCCGCTCCCTGGAGGGCCGCGGGGTGAAGATTGCCCGTGCCCTGGTG
GGCACCTTCATGTCAGCACTGGAGATGCCTGGCATTTCTCTCACCCTCCTGCTGGTGGAT
GAGCCTCTCCTGAAACTGATAGATGCTGAAACCACTGCAGCAGCCTGGCCTAACGTGGCT
GCAGTCTCCATTACTGGGCGGAAGCGGAGCCGGGTAGCCCCTGCCGAGCCCCAGGAGGCC
CCTGATTCCACTGCTGCAGGAGGCTCAGCCTCGAAGCGGATGGCGCCGGTGCTGGAACGG
GTGTGCAGCACTCTCCTGGGCCTGGAGGAACACCTGAATGCCCTGGACCGGGCTGCTGGT
GACGGCGACTGTGGCACCACCCACAGCCGTGCGGCCAGAGCAATCCAGGAGTGGCTGAAG
GAGGGCCCACCCCCTGCCAGCCCTGCCCAGCTGCTCTCCAAGTTGTCTGTTCTGCTCCTG
GAGAAGATGGGAGGCTCATCTGGGGCGCTCTATGGCCTGTTCCTGACTGCGGCTGCACAG
CCCCTGAAGGCCAAGACCAGCCTCCCAGCCTGGTCTGCTGCCATGGATGCCGGCCTGGAA
GCCATGCAGAAGTATGGCAAGGCTGCTCCAGGGGACAGGACTATGCTGGGTTCTCTGTGG
GCAGCGGGGCAGGAGCTCCAAGCCTGGAAGAGCCCAGGAGCTGATCTGTTACAAGTCCTG
ACCAAAGCAGTCAAGAGTGCCGAAGCTGCAGCCGAGGCCACCAAGAATATGGAAGCTGGA
GCCGGAAGAGCCAGTTATATCAGCTCAGCACGGCTGGAGCAGCCAGACCCCGGGGCGGTG
GCAGCTGCTGCCATCCTCCGGGCCATCTTGGAGGTCTTGCAGAGCTAG

Protein Properties

Number of Residues

575

Molecular Weight

58946.49

Theoretical pI

7.493

Pfam Domain Function

Dak1 (PF02733 )
Dak2 (PF02734 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)
MTSKKLVNSVAGCADDALAGLVACNPNLQLLQGHRVALRSDLDSLKGRVALLSGGGSGHE
PAHAGFIGKGMLTGVIAGAVFTSPAVGSILAAIRAVAQAGTVGTLLIVKNYTGDRLNFGL
AREQARAEGIPVEMVVIGDDSAFTVLKKAGRRGLCGTVLIHKVAGALAEAGVGLEEIAKQ
VNVVTKAMGTLGVSLSSCSVPGSKPTFELSADEVELGLGIHGEAGVRRIKMATADEIVKL
MLDHMTNTTNASHVPVQPGSSVVMMVNNLGGLSFLELGIIADATVRSLEGRGVKIARALV
GTFMSALEMPGISLTLLLVDEPLLKLIDAETTAAAWPNVAAVSITGRKRSRVAPAEPQEA
PDSTAAGGSASKRMALVLERVCSTLLGLEEHLNALDRAAGDGDCGTTHSRAARAIQEWLK
EGPPPASPAQLLSKLSVLLLEKMGGSSGALYGLFLTAAAQPLKAKTSLPAWSAAMDAGLE
AMQKYGKAAPGDRTMLDSLWAAGQELQAWKSPGADLLQVLTKAVKSAEAAAEATKNMEAG
AGRASYISSARLEQPDPGAVAAAAILRAILEVLQS

External Links

GenBank ID Protein

10435998

UniProtKB/Swiss-Prot ID

Q3LXA3

UniProtKB/Swiss-Prot Entry Name

DHAK_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AK023915

GeneCard ID