| Identification |
|---|
| HMDB Protein ID
| CDBP01982 |
| Secondary Accession Numbers
| Not Available |
| Name
| Poly(ADP-ribose) glycohydrolase ARH3 |
| Description
| Not Available |
| Synonyms
|
- ADP-ribosylhydrolase 3
- [Protein ADP-ribosylarginine] hydrolase-like protein 2
|
| Gene Name
| ADPRHL2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Posttranslational modification, protein turnover, chaperones |
| Specific Function
| Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p34.3 |
| SNPs
| ADPRHL2 |
| Gene Sequence
|
>1092 bp
ATGGCCCAGCGGCGATGGCGGCACGGCAGGTTGGAGGGGCTGGCGCGGCCGCTCCCTCTC
GCGCTTCCGAGGCTGCCTGGCTGGCGCGCTGCTCGGGGACTGCGTGGGCTCCTTCTACGA
GGCCCACGACACCGTCGACCTGACGTCATCGTGCGTCATGTCCAGAGTCTGGAGCCGGAC
CCCGTACTGCCCCGGGAAGTGAGCGGACAGAAGCCTTTGTACTACACAGATGACACAGCC
ATGGCCAGGGCCCTGGTGCAGTCCCTGCTAGCCAAGGAGGCCTTTGACGAGGTGGACATG
GCTCACAGATTTGCTCAGGAGTACAAGAAAGACCCTGACAGGGGCTATGGTGCTGGAGTA
GTCACTGTCTTCAAGAAGCTCCTGAACCCCAAATGTCGCGATGTCTTTGAGCCTGCCCGG
GCCCAGTTTAACGGGAAAGGCTCCTATGGCAATGGAGGTGCCATGCGGGTGGCTGGCATC
TCCCTGGCCTATAGCAGTGTCCAGGATGTGCAGAAGTTTGCCCGGCTCTCGGCCCAGCTG
ACACACGCCTCCTCCCTGGGTTACAATGGCGCCATCCTGCAGGCCCTGGCTGTGCACCTG
GCCTTGCAGGGCGAGTCTTCCAGCGAGCACTTTCTCAAGCAACTCCTGGGCCACATGGAG
GATCTGGAGGGTGATGCCCAGTCCGTCTTGGATGCCAGGGAGTTGGGCATGGAGGAGCGT
CCATACTCCAGCCGCCTGAAGAAGATTGGAGAGCTTCTAGACCAGGCATCGGTGACCAGG
GAGGAAGTGGTGTCTGAGCTAGGGAATGGCATTGCTGCCTTTGAGTCGGTACCCACCGCC
ATCTACTGCTTCCTACGCTGCATGGAGCCAGACCCTGAGATCCCTTCTGCCTTCAATAGC
CTCCAAAGGACTCTCATTTATTCCATCTCACTTGGTGGGGACACAGACACCATTGCCACC
ATGGCTGGGGCCATTGCTGGTGCCTACTATGGGATGGATCAGGTGCCAGAGAGCTGGCAG
CAAAGCTGTGAAGGCTACGAGGAGACAGACATCCTGGCCCAAAGCCTGCACCGTGTCTTC
CAGAAGAGTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 363 |
| Molecular Weight
| 38946.4 |
| Theoretical pI
| 4.7 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Poly(ADP-ribose) glycohydrolase ARH3
MAAAAMAAAAGGGAGAARSLSRFRGCLAGALLGDCVGSFYEAHDTVDLTSVLRHVQSLEP
DPGTPGSERTEALYYTDDTAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAGV
VTVFKKLLNPKCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSAQL
THASSLGYNGAILQALAVHLALQGESSSEHFLKQLLGHMEDLEGDAQSVLDARELGMEER
PYSSRLKKIGELLDQASVTREEVVSELGNGIAAFESVPTAIYCFLRCMEPDPEIPSAFNS
LQRTLIYSISLGGDTDTIATMAGAIAGAYYGMDQVPESWQQSCEGYEETDILAQSLHRVF
QKS
|
| External Links |
|---|
| GenBank ID Protein
| 13182753 |
| UniProtKB/Swiss-Prot ID
| Q9NX46 |
| UniProtKB/Swiss-Prot Entry Name
| ARHL2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF212236 |
| GeneCard ID
| ADPRHL2 |
| GenAtlas ID
| ADPRHL2 |
| HGNC ID
| HGNC:21304 |
| References |
|---|
| General References
| Not Available |