| Identification |
|---|
| HMDB Protein ID
| CDBP01969 |
| Secondary Accession Numbers
| Not Available |
| Name
| Adiponectin |
| Description
| Not Available |
| Synonyms
|
- 30 kDa adipocyte complement-related protein
- ACRP30
- Adipocyte complement-related 30 kDa protein
- Adipocyte, C1q and collagen domain-containing protein
- Adipose most abundant gene transcript 1 protein
- Gelatin-binding protein
- apM-1
|
| Gene Name
| ADIPOQ |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in cytokine activity |
| Specific Function
| Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q27 |
| SNPs
| ADIPOQ |
| Gene Sequence
|
>735 bp
ATGCTGTTGCTGGGAGCTGTTCTACTGCTATTAGCTCTGCCCGGTCATGACCAGGAAACC
ACGACTCAAGGGCCCGGAGTCCTGCTTCCCCTGCCCAAGGGGGCCTGCACAGGTTGGATG
GCGGGCATCCCAGGGCATCCGGGCCATAATGGGGCCCCAGGCCGTGATGGCAGAGATGGC
ACCCCTGGTGAGAAGGGTGAGAAAGGAGATCCAGGTCTTATTGGTCCTAAGGGAGACATC
GGTGAAACCGGAGTACCCGGGGCTGAAGGTCCCCGAGGCTTTCCGGGAATCCAAGGCAGG
AAAGGAGAACCTGGAGAAGGTGCCTATGTATACCGCTCAGCATTCAGTGTGGGATTGGAG
ACTTACGTTACTATCCCCAACATGCCCATTCGCTTTACCAAGATCTTCTACAATCAGCAA
AACCACTATGATGGCTCCACTGGTAAATTCCACTGCAACATTCCTGGGCTGTACTACTTT
GCCTACCACATCACAGTCTATATGAAGGATGTGAAGGTCAGCCTCTTCAAGAAGGACAAG
GCTATGCTCTTCACCTATGATCAGTACCAGGAAAATAATGTGGACCAGGCCTCCGGCTCT
GTGCTCCTGCATCTGGAGGTGGGCGACCAAGTCTGGCTCCAGGTGTATGGGGAAGGAGAG
CGTAATGGACTCTATGCTGATAATGACAATGACTCCACCTTCACAGGCTTTCTTCTCTAC
CATGACACCAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 244 |
| Molecular Weight
| 26413.6 |
| Theoretical pI
| 5.53 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Adiponectin
MLLLGAVLLLLALPGHDQETTTQGPGVLLPLPKGACTGWMAGIPGHPGHNGAPGRDGRDG
TPGEKGEKGDPGLIGPKGDIGETGVPGAEGPRGFPGIQGRKGEPGEGAYVYRSAFSVGLE
TYVTIPNMPIRFTKIFYNQQNHYDGSTGKFHCNIPGLYYFAYHITVYMKDVKVSLFKKDK
AMLFTYDQYQENNVDQASGSVLLHLEVGDQVWLQVYGEGERNGLYADNDNDSTFTGFLLY
HDTN
|
| External Links |
|---|
| GenBank ID Protein
| 6362247 |
| UniProtKB/Swiss-Prot ID
| Q15848 |
| UniProtKB/Swiss-Prot Entry Name
| ADIPO_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB012165 |
| GeneCard ID
| ADIPOQ |
| GenAtlas ID
| ADIPOQ |
| HGNC ID
| HGNC:13633 |
| References |
|---|
| General References
| Not Available |