| Identification |
|---|
| HMDB Protein ID
| CDBP01958 |
| Secondary Accession Numbers
| Not Available |
| Name
| L-2-hydroxyglutarate dehydrogenase, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- Duranin
|
| Gene Name
| L2HGDH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 2-hydroxyglutarate dehydrogenase activity |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| cellular protein metabolic process |
| 2-oxoglutarate metabolic process |
| Cellular Component |
| integral to mitochondrial inner membrane |
| Function |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| 2-hydroxyglutarate dehydrogenase activity |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Butanoate metabolism | Not Available |  | | The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria |    | Not Available | | The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| 14q21.3 |
| SNPs
| L2HGDH |
| Gene Sequence
|
>1392 bp
ATGGTGCCAGCGCTGCGTTATTTGGTTGGTGCCTGCGGACGGGCCCGCGGGCTTTTCGCC
GGTGGCTCCCCTGGGGCGTGCGGGTTCGCGTCTGGGAGGCCAAGACCGCTGTGTGGAGGT
AGCCGCAGCGCCAGCACCAGCTCATTTGATATAGTCATCGTTGGTGGCGGAATTGTGGGG
CTTGCCTCTGCCAGAGCACTCATCCTGCGACATCCATCACTTTCTATTGGTGTTCTGGAA
AAGGAGAAAGATTTAGCTGTTCACCAGACTGGACATAACAGTGGTGTCATACATAGTGGA
ATTTATTATAAACCTGAGTCTCTGAAAGCCAAATTATGTGTACAAGGTGCAGCCCTCCTC
TATGAGTACTGTCAGCAAAAGGGGATTTCCTACAAGCAGTGTGGCAAGCTTATAGTAGCT
GTTGAACAAGAAGAAATTCCCAGACTTCAGGCCCTATATGAGAAAGGCCTCCAGAATGGT
GTCCCGGGCCTGAGGCTGATCCAGCAGGAGGATATAAAAAAGAAGGAGCCATATTGTAGG
GGTCTAATGGCTATTGATTGTCCACATACTGGCATTGTGGACTATCGGCAGGTGGCTTTG
TCATTTGCCCAGGATTTCCAAGAAGCAGGTGGCTCTGTCTTGACCAATTTTGAAGTAAAA
GGTATTGAAATGGCTAAAGAAAGTCCTTCAAGAAGTATAGATGGAATGCAATATCCAATT
GTTATAAAGAATACAAAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTGCAGGA
CTTTACTCAGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGATCCTCGAATTGTACCA
TTCCGGGGAGATTACCTGCTTTTGAAGCCAGAAAAATGTTATCTTGTAAAAGGAAATATT
TATCCGGTCCCAGATAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGATGGAT
GGCAGTATTTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACGAGAGGGTTACAGACCC
TTTGACTTCAGTGCCACAGATGTTATGGATATAATTATCAATAGTGGCTTGATTAAACTG
GCATCCCAGAATTTTTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTGGTGCA
ACAGTGAAGTATCTTCAAAAATTCATCCCTGAAATTACTATCAGTGATATACTTAGGGGC
CCAGCTGGAGTAAGAGCCCAGGCCCTGGATAGAGATGGAAATCTGGTAGAAGATTTTGTA
TTTGATGCAGGAGTTGGGGATATTGGAAATCGCATTCTTCATGTGAGAAATGCACCTTCT
CCTGCTGCTACTTCTTCCATTGCAATTTCTGGAATGATTGCAGATGAAGTACAACAAAGA
TTTGAATTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 463 |
| Molecular Weight
| 50315.58 |
| Theoretical pI
| 8.145 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>L-2-hydroxyglutarate dehydrogenase, mitochondrial
MVPALRYLVGACGRARGRFAGGSPGACGFASGRPRPLCGGSRSASTSSFDIVIVGGGIVG
LASARALILRHPSLSIGVLEKEKDLAVHQTGHNSGVIHSGIYYKPESLKAKLCVQGAALL
YEYCQQKGISYKQCGKLIVAVEQEEIPRLQALYEKGLQNGVPGLRLIQQEDIKKKEPYCR
GLMAIDCPHTGIVDYRQVALSFAQDFQEAGGSVLTNFEVKGIEMAKESPSRSIDGMQYPI
VIKNTKGEEIRCQYVVTCAGLYSDRISELSGCTPDPRIVPFRGDYLLLKPEKCYLVKGNI
YPVPDSRFPFLGVHFTPRMDGSIWLGPNAVLAFKREGYRPFDFSATDVMDIIINSGLIKL
ASQNFSYGVTEMYKACFLGATVKYLQKFIPEITISDILRGPAGVRAQALDRDGNLVEDFV
FDAGVGDIGNRILHVRNAPSPAATSSIAISGMIADEVQQRFEL
|
| External Links |
|---|
| GenBank ID Protein
| 10434215 |
| UniProtKB/Swiss-Prot ID
| Q9H9P8 |
| UniProtKB/Swiss-Prot Entry Name
| L2HDH_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK022680 |
| GeneCard ID
| L2HGDH |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:20499 |
| References |
|---|
| General References
| Not Available |