| Identification |
|---|
| HMDB Protein ID
| CDBP01951 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ileal sodium/bile acid cotransporter |
| Description
| Not Available |
| Synonyms
|
- ASBT
- Apical sodium-dependent bile acid transporter
- IBAT
- ISBT
- Ileal Na(+)/bile acid cotransporter
- Ileal sodium-dependent bile acid transporter
- Na(+)-dependent ileal bile acid transporter
- Sodium/taurocholate cotransporting polypeptide, ileal
- Solute carrier family 10 member 2
|
| Gene Name
| SLC10A2 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in bile acid:sodium symporter activity |
| Specific Function
| Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism |
| GO Classification
|
| Component |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| bile acid:sodium symporter activity |
| organic acid transmembrane transporter activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| organic acid:sodium symporter activity |
| transporter activity |
| Process |
| sodium ion transport |
| establishment of localization |
| transport |
| organic anion transport |
| anion transport |
| monovalent inorganic cation transport |
| ion transport |
| cation transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 13q33 |
| SNPs
| SLC10A2 |
| Gene Sequence
|
>1047 bp
ATGAATGATCCGAACAGCTGTGTGGACAATGCAACAGTTTGCTCTGGTGCATCCTGTGTG
GTACCTGAGAGCAATTTCAATAACATCCTAAGTGTGGTCCTAAGTACGGTGCTGACCATC
CTGTTGGCCTTGGTGATGTTCTCCATGGGATGCAACGTGGAAATCAAGAAATTTCTAGGG
CACATAAAGCGGCCGTGGGGCATTTGTGTTGGCTTCCTCTGTCAGTTTGGAATCATGCCC
CTCACAGGATTCATCCTGTCGGTGGCCTTTGACATCCTCCCGCTCCAGGCCGTAGTGGTG
CTCATTATAGGATGCTGCCCTGGAGGAACTGCCTCCAATATCTTGGCCTATTGGGTCGAT
GGCGACATGGACCTGAGCGTCAGCATGACCACATGCTCCACACTGCTTGCCCTCGGAATG
ATGCCGCTGTGCCTCCTTATCTATACCAAAATGTGGGTCGACTCTGGGAGCATCGTAATT
CCCTATGATAACATAGGTACATCTCTGGTTGCTCTCGTTGTTCCTGTTTCCATTGGAATG
TTTGTTAATCACAAATGGCCCCAAAAAGCAAAGATCATACTTAAAATTGGGTCCATCGCG
GGCGCCATCCTCATTGTGCTCATAGCTGTGGTTGGAGGAATATTGTACCAAAGCGCCTGG
ATCATTGCTCCCAAACTGTGGATTATAGGAACAATATTTCCTGTGGCGGGTTACTCCCTG
GGGTTTCTTCTGGCTAGAATTGCTGGTCTACCCTGGTACAGGTGCCGAACGGTTGCTTTT
GAAACGGGGATGCAGAACACGCAGCTATGTTCCACCATCGTTCAGCTCTCCTTCACTCCT
GAGGAGCTCAATGTCGTATTCACCTTCCCGCTCATCTACAGCATTTTCCAGCTCGCCTTT
GCCGCAATATTCTTAGGATTTTATGTGGCATACAAGAAATGTCATGGAAAAAACAAGGCA
GAAATTCCAGAGAGCAAAGAAAATGGAACGGAGCCAGAGTCATCGTTTTATAAGGCAAAT
GGAGGATTTCAACCTGACGAAAAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 348 |
| Molecular Weight
| 37697.4 |
| Theoretical pI
| 7.13 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["29-49", "83-103", "127-147", "158-178", "196-216", "225-245", "285-305"]
|
| Protein Sequence
|
>Ileal sodium/bile acid cotransporter
MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMFSMGCNVEIKKFLG
HIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVVLIIGCCPGGTASNILAYWVD
GDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVIPYDNIGTSLVALVVPVSIGM
FVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIAPKLWIIGTIFPVAGYSL
GFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAF
AAIFLGFYVAYKKCHGKNKAEIPESKENGTEPESSFYKANGGFQPDEK
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q12908 |
| UniProtKB/Swiss-Prot Entry Name
| NTCP2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U10417 |
| GeneCard ID
| SLC10A2 |
| GenAtlas ID
| SLC10A2 |
| HGNC ID
| HGNC:10906 |
| References |
|---|
| General References
| Not Available |