| Identification |
|---|
| HMDB Protein ID
| CDBP01946 |
| Secondary Accession Numbers
| Not Available |
| Name
| Apoptosis regulator Bcl-2 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| BCL2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in regulation of apoptosis |
| Specific Function
| Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cell death |
| regulation of programmed cell death |
| regulation of apoptosis |
| regulation of cellular process |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Single-pass membrane protein
- Single-pass membrane protein
- Single-pass membrane protein
- Mitochondrion outer membrane
- Nucleus membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 18q21.33|18q21.3 |
| SNPs
| BCL2 |
| Gene Sequence
|
>720 bp
ATGGCGCACGCTGGGAGAACAGGGTACGATAACCGGGAGATAGTGATGAAGTACATCCAT
TATAAGCTGTCGCAGAGGGGCTACGAGTGGGATGCGGGAGATGTGGGCGCCGCGCCCCCG
GGGGCCGCCCCCGCACCGGGCATCTTCTCCTCCCAGCCCGGGCACACGCCCCATCCAGCC
GCATCCCGGGACCCGGTCGCCAGGACCTCGCCGCTGCAGACCCCGGCTGCCCCCGGCGCC
GCCGCGGGGCCTGCGCTCAGCCCGGTGCCACCTGTGGTCCACCTGACCCTCCGCCAGGCC
GGCGACGACTTCTCCCGCCGCTACCGCCGCGACTTCGCCGAGATGTCCAGCCAGCTGCAC
CTGACGCCCTTCACCGCGCGGGGACGCTTTGCCACGGTGGTGGAGGAGCTCTTCAGGGAC
GGGGTGAACTGGGGGAGGATTGTGGCCTTCTTTGAGTTCGGTGGGGTCATGTGTGTGGAG
AGCGTCAACCGGGAGATGTCGCCCCTGGTGGACAACATCGCCCTGTGGATGACTGAGTAC
CTGAACCGGCACCTGCACACCTGGATCCAGGATAACGGAGGCTGGGATGCCTTTGTGGAA
CTGTACGGCCCCAGCATGCGGCCTCTGTTTGATTTCTCCTGGCTGTCTCTGAAGACTCTG
CTCAGTTTGGCCCTGGTGGGAGCTTGCATCACCCTGGGTGCCTATCTGGGCCACAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 239 |
| Molecular Weight
| 26265.7 |
| Theoretical pI
| 7.32 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Apoptosis regulator Bcl-2
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
|
| External Links |
|---|
| GenBank ID Protein
| 28144173 |
| UniProtKB/Swiss-Prot ID
| P10415 |
| UniProtKB/Swiss-Prot Entry Name
| BCL2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY220759 |
| GeneCard ID
| BCL2 |
| GenAtlas ID
| BCL2 |
| HGNC ID
| HGNC:990 |
| References |
|---|
| General References
| Not Available |