| Identification |
|---|
| HMDB Protein ID
| CDBP01936 |
| Secondary Accession Numbers
| Not Available |
| Name
| Early endosome antigen 1 |
| Description
| Not Available |
| Synonyms
|
- Endosome-associated protein p162
- Zinc finger FYVE domain-containing protein 2
|
| Gene Name
| EEA1 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
|
| Cellular Location
|
- Cytoplasm
- Peripheral membrane protein
- Early endosome membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q22 |
| SNPs
| EEA1 |
| Gene Sequence
|
>4233 bp
ATGTTAAGGAGGATTTTACAGAGGACTCCTGGGAGAGTTGGCTCTCAAGGTTCTGATTTA
GATTCATCAGCAACTCCTATAAACACAGTGGACGTCAATAATGAAAGCTCTTCAGAAGGT
TTCATATGTCCCCAGTGTATGAAATCTCTTGGATCTGCTGATGAACTTTTCAAACATTAT
GAAGCTGTTCATGATGCTGGTAATGACTCAGGTCATGGAGGAGAGTCTAATCTTGCTTTG
AAGCGAGATGATGTAACACTGCTCAGACAAGAGGTCCAAGACCTACAGGCTTCACTTAAG
GAAGAAAAATGGTACTCGGAAGAATTAAAGAAGGAATTAGAAAAATATCAAGGGCTGCAG
CAGCAAGAGGCCAAACCTGATGGGTTGGTGACTGATTCATCAGCAGAACTACAGTCTTTG
GAACAGCAATTAGAAGAAGCCCAAACAGAAAATTTTAATATTAAGCAAATGAAAGACTTA
TTTGAACAGAAAGCAGCCCAACTTGCTACTGAAATTGCAGATATAAAGTCAAAGTATGAT
GAAGAAAGGAGTCTTCGAGAAGCTGCTGAACAAAAAGTGACACGTCTGACAGAAGAATTA
AACAAAGAGGCAACTGTAATTCAAGATCTGAAGACGGAACTGCTTCAGAGACCTGGTATA
GAAGATGTTGCCGTGCTAAAGAAAGAACTGGTCCAAGTTCAAACACTAATGGATAACATG
ACCTTGGAACGTGAGCGAGAATCTGAAAAACTCAAAGATGAATCGAAAAAATTCGAGTCA
CAATATGCTAGCTCAGAGGCCACAATAAGCCAGCTAAGGAGTGAACTGTCCAAAGGCCCC
CAGGAAGTTCGTGTATATGTACAGGAACTACAAAAACTGAAAAGTTCAGTTAATGAATTA
ACACAAAAAAATCAGACCTTGACAGAAAACTTGCTGAAAAAAGAACAAGACTATACTAAG
TTAGAGGAGAAACATAATGAAGAATCTGTGAGTAAAAAGAATATTCAGGCAACCCTTCAT
CAAAAAGACCTAGATTGTCAACAGCTTCAGTCAAGATTGTCTGCATCTGAAACCTCACTG
CATAGAATACATGTAGAACTAAGTGAAAAAGGAGAAGCTACTCAAAAGCTCAAAGAAGAA
TTATCTGAGGTAGAGACCAAGTACCAGCATCTAAAGGCGGAGTTTAAGCAGCTACAACAA
CAGAGAGAAGAAAAGGAGCAGCATGGGTTACAACTCCAAAGTGAAATTAATCAATTACAT
AGCAAACTTCTGGAGACAGAGCGCCAACTAGGGGAAGCTCATGGTAGGCTGAAGGAACAG
AGACAGCTTTCAAGTGAAAAGTTGATGGATAAAGAACAACAAGTGGCTGATTTACAACTC
AAACTTTCTCGGTTAGAAGAGCAGTTGAAGGAAAAAGTTACAAATTCTACAGAATTGCAG
CATCAATTAGATAAAACAAAGCAACAGCATCAAGAACAACAGGCTCTTCAGCAAAGCACC
ACGGCAAAACTTCGAGAAGCTCAGAATGATTTGGAACAAGTTCTACGTCAAATTGGCGAA
AAGGACCAAAAGATCCAGAACCTTGAAGCTTTATTACAGAAGAGTAAAGAAAATATTTCA
TTACTAGAAAAAGAAAGAGAAGATCTTTATGCAAAAATTCAGGCTGGTGAAGGAGAGACT
GCTGTTCTTAACCAGTTACAAGAAAAAAACCATACACTACAGGACGAAGTAACTCAACTA
ACAGAGAACGTGAAGAATCAGTCAGAAAGTCATAAACAAGCCCAGGAGAATTTGCATGAC
CAGGTACAAGAGCAGAAGGCACATCTTAGAGCTGCACAAGACCGTGTCCTTTCCCTAGAA
ACTAGTGTCAATGAATTAAATAGTCAATTAAATGAAAGCAAGGAGAAGGTCTCCCAGCTT
GACATACAGATTAAAGCCAAAACCGAACTATTACTATCAGCAGAAGCAGCAAAAACTGCT
CAAAGAGCTGATCTTCAGAATCATTTGGACACAGCTCAAAATGCATTACAAGATAAACAC
CAGGAGTTAAATAAGATTACTACTCAGTTGGATCAGGTCACTGCAAAGTTACAAGACAAG
CAAGAACATTGCAGTCAGCTGGAAAGTCATCTTAAAGAATATAAAGAGAAATACCTCTCT
TTAGAACAGAAAACCGAAGAGCTAGAAGGTCAAATTAAGAAACTAGAAGCTGATAGTCTT
GAAGTTAAAGCAAGCAAGGAGCAGGCTTTGCAAGATCTACAACAGCAAAGACAGCTGAAC
ACAGATTTAGAGCTCAGAGCCACAGAATTGAGTAAACAACTTGAAATGGAGAAGGAAATA
GTATCCAGTACAAGATTGGATCTACAGAAAAAATCTGAAGCCCTTGAAAGTATCAAGCAA
AAGCTTACCAAGCAAGAGGAAGAAAAACAAATCCTGAAACAAGATTTTGAAACTTTAAGT
CAAGAAACAAAGATTCAGCATGAGGAATTGAATAACAGAATTCAAACAACAGTAACAGAA
CTACAAAAAGTGAAAATGGAGAAAGAAGCTTTAATGACAGAGCTTTCTACAGTAAAGGAC
AAACTATCAAAAGTTTCTGATTCTTTGAAAAACTCTAAAAGTGAATTTGAAAAGGAGAAT
CAGAAAGGAAAAGCCGCTATATTAGACTTGGAAAAAACTTGCAAAGAATTAAAGCATCAA
CTTCAAGTGCAGATGGAAAACACACTTAAGGAACAGAAGGAACTGAAAAAGTCACTTGAA
AAAGAGAAGGAGGCTTCTCATCAGTTGAAATTGGAACTCAATTCAATGCAGGAACAACTT
ATACAGGCCCAGAATACTTTAAAACAAAATGAAAAAGAAGAGCAACAACTTCAGGGGAAC
ATAAATGAGCTAAAGCAATCAAGTGAACAGAAGAAAAAACAAATTGAAGCACTCCAAGGA
GAGCTTAAAATTGCTGTTTTACAGAAGACAGAGCTTGAGAATAAACTACAGCAGCAGTTA
ACACAGGCAGCCCAGGAACTTGCAGCAGAGAAAGAGAAAATATCAGTATTACAAAACAAC
TATGAAAAAAGTCAGGAAACTTTCAAACAGCTTCAATCTGATTTCTATGGGAGGGAATCT
GAACTTCTAGCCACCAGGCAAGATCTTAAGTCTGTAGAAGAGAAGCTTTCTCTAGCACAG
GAGGACTTGATTTCAAACAGAAATCAAATTGGAAATCAAAATAAATTGATTCAAGAACTG
AAGACTGCCAAGGCTACATTGGAGCAGGATTCAGCAAAGAAAGAACAGCAATTGCAGGAG
CGATGTAAAGCACTACAAGACATTCAGAAAGAAAAGTCACTGAAAGAAAAAGAACTGGTA
AATGAGAAGTCTAAATTGGCAGAGATAGAAGAAATTAAATGTAGACAAGAAAAAGAAATC
ACTAAACTAAACGAAGAACTCAAGTCCCACAAACTAGAAAGCATAAAGGAGATAACAAAT
CTTAAAGATGCTAAACAGCTTCTAATTCAGCAGAAATTAGAACTTCAAGGAAAAGCGGAC
TCCCTGAAGGCAGCTGTTGAACAGGAGAAGAGAAATCAGCAGATACTAAAAGACCAGGTG
AAAAAGGAAGAAGAGGAGCTGAAGAAAGAATTTATTGAGAAAGAAGCTAAGTTGCATTCC
GAAATAAAAGAAAAGGAAGTAGGAATGAAGAAGCATGAAGAAAATGAGGCTAAACTTACC
ATGCAGATTACAGCATTAAATGAAAACTTAGGCACTGTGAAGAAGGAGTGGCAATCTAGT
CAACGGAGAGTTAGTGAGCTTGAGAAACAAACGGATGACTTACGGGGTGAAATTGCAGTA
TTAGAAGCAACGGTTCAGAATAATCAAGATGAAAGGAGAGCACTACTGGAAAGATGTCTT
AAAGGAGAAGGTGAAATAGAAAAGCTTCAAACCAAAGTATTAGAATTGCAAAGAAAGCTG
GATAATACAACTGCAGTGCAGGAGCTGGGCAGAGAAAACCAATCACTTCAGATCAAACAT
ACACAAGCGTTGAATAGAAAGTGGGCCGAAGACAATGAAGTACAAAACTGTATGGCCTGT
GGGAAAGGCTTTTCAGTAACAGTGAGACGGCATCACTGCCGACAGTGTGGAAATATCTTC
TGTGCTGAATGTTCAGCCAAAAATGCCTTAACTCCTTCCTCCAAGAAGCCTGTTCGTGTC
TGTGATGCATGTTTCAATGACTTGCAAGGATAA
|
| Protein Properties |
|---|
| Number of Residues
| 1411 |
| Molecular Weight
| 162464.9 |
| Theoretical pI
| 5.41 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Early endosome antigen 1
MLRRILQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHY
EAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQ
QQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYD
EERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNM
TLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL
TQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSL
HRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH
SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ
HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS
LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD
QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTA
QRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLS
LEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI
VSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTE
LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ
LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN
INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN
YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL
KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI
TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV
KKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSS
QRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL
DNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNI
FCAECSAKNALTPSSKKPVRVCDACFNDLQG
|
| External Links |
|---|
| GenBank ID Protein
| 1016368 |
| UniProtKB/Swiss-Prot ID
| Q15075 |
| UniProtKB/Swiss-Prot Entry Name
| EEA1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| L40157 |
| GeneCard ID
| EEA1 |
| GenAtlas ID
| EEA1 |
| HGNC ID
| HGNC:3185 |
| References |
|---|
| General References
| Not Available |